|别名||对氨基酚 ;对羟基苯胺，对氨基苯酚，4-氨基苯酚 ;UrsolP Rodinal 4-Amino-1-hydroxybenzene p-Hyddroxyaniline 4-Aminophenol 4-Hydroxyaniline|
|标识符号||GHS07, GHS08, GHS09|
|个人防护设备||dust mask type N95 (US),Eyeshields,Faceshields,Gloves|
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Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid
Inhibition of 12 mammalian isoforms of the metalloenzyme carbonic anhydrase (CA, EC 188.8.131.52), CA I-XIV, with a series of phenols was investigated. The inhibition profile by phenols of these CAs was di...Read More
Pseudomonas aeruginosa strain HJ1012 was isolated on paracetamol as a sole carbon and energy source. This organism could completely degrade paracetamol as high as 2200?mg/L. Following paracetamol cons...Read More
This theoretical and experimental study describes the design and evaluation of the free-radical scavenging effect for the molecular association of 4-aminophenol and salicylate derivatives. For this pu...Read More
Graphene-modified Interdigitated Array Electrode: Fabrication, Characterization, and Electrochemical Immunoassay Application.
We have developed a new procedure for fabricating interdigitated array gold electrodes (Au-IDA) modified with reduced graphene oxide (rGO). In this procedure, we coated the gold surface of the microm...Read More
Kidney injury biomarkers have been utilized by pharmaceutical companies as a means to assess the potential of candidate drugs to induce nephrotoxicity. Multiple platforms and assay methods exist, but ...Read More
AAN effective sensor: The two-photon turn-on fluorescent probe NHU was synthesized to optically detect tyrosinase activity in vitro and in melanoma cells. NHU is composed of a 4-aminophenol moiety and...Read More
Stability-Indicating TLC-Densitometric Method for Simultaneous Determination of Paracetamol and Chlorzoxazone and their Toxic Impurities.
A highly sensitive, selective and accurate thin-layer chromatographic (TLC)-densitometric method has been developed and validated for the simultaneous determination of paracetamol (PAR) and chlorzoxaz...Read More
Highly sensitive sequential injection determination of p-aminophenol in paracetamol formulations with 18-molybdodiphosphate heteropoly anion based on elimination of Schlieren effect.
A highly sensitive, precise and automated method using sequential injection analysis to assay quantitatively low levels of the p-aminophenol (PAP) in paracetamol formulations has been developed. A sol...Read More
In this work, a novel immunosensing method has been developed on the basis of the sensitive determination of a product generated by an enzyme reaction with dual amplification system combining an elect...Read More
A Pt layer/Pt disk electrode configuration to evaluate respiration and alkaline phosphatase activities of mouse embryoid bodies.
A Pt layer/Pt disk electrode configuration was used as a scanning electrochemical microscopy (SECM) probe. The glass seal part of the insulator was covered with a Pt layer to form an exposed pseudo re...Read More
Separation and electrochemical detection of paracetamol and 4-aminophenol in a paper-based microfluidic device
The present work describes the construction and application of a simple, low cost and sensitive microfluidic paper-based device with electrochemical detection for the detection of paracetamol and 4-am...Read More
A manganese oxide with phenol groups as a promising structural model for water oxidizing complex in Photosystem II: a 'golden fish'.
We describe here the ability of manganese oxide monosheets to aggregate to form layered structures with 4-aminophenol molecules. These aggregated monosheets could be considered as the first step to sy...Read More
This paper reports chemical-chemical (CC) and electrochemical-chemical-chemical (ECC) redox cycling, for use in ultrasensitive biosensor applications. A triple chemical amplification approach using an...Read More
Production of p-acetaminophenol by whole-cell catalysis using Escherichia coli overexpressing bacterial aryl acylamidase.
Aryl acylamidase (EC 184.108.40.206, AAA) acts on the amide bond between aryl and acyl groups. Whole cells of Escherichia coli overexpressing a novel bacterial AAA synthesized p-acetaminophenol (p-AAP) from...Read More
Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughp...Read More
Catalytic reduction of 4-nitrophenol using biogenic gold and silver nanoparticles derived from Breynia rhamnoides.
A simple, green method is described for the synthesis of Gold (Au) and Silver (Ag) nanoparticles (NPs) from the stem extract of Breynia rhamnoides. Unlike other biological methods for NP synthesis, th...Read More
An electrochemical sensor for p-aminophenyl phosphate (pAPP) is reported. It is based on the electrochemical conversion of 4-aminophenol (4AP) at a quantum dot (QD) modified electrode under illuminati...Read More
Voltammetric determination of glutathione in haemolysed erythrocyte and tablet samples using modified-multiwall carbon nanotubes paste electrode.
A chemically modified electrode was prepared by incorporating p-aminophenol into multiwall carbon nanotubes paste matrix. Cyclic voltammetry, square wave voltammetry, double potential step chronoamper...Read More
Facile synthesis of two-dimensional graphene/SnO? /Pt ternary hybrid nanomaterials and their catalytic properties.
In this paper, we reported a simple, aqueous-phase route to the synthesis of two-dimensional graphene/SnO(2) composite nanosheets (GSCN) hybrid nanostructures consisting of 5 nm Pt nanoparticles suppo...Read More
Simultaneous determination of N-acetyl-p-aminophenol and p-aminophenol with poly(3,4-ethylenedioxythiophene) modified glassy carbon electrode.
A sensitive and selective method was developed for the determination of N-acetyl-p-aminophenol (APAP) and p-aminophenol (PAP) using poly(3,4-ethylenedioxythiophene) (PEDOT)-modified glassy carbon elec...Read More
Three bacterial strains utilizing paracetamol as the sole carbon, nitrogen, and energy source were isolated from a paracetamol-degrading aerobic aggregate, and assigned to species of the genera Stenot...Read More
Facile synthesis of highly dispersed palladium/polypyrrole nanocapsules for catalytic reduction of p-nitrophenol.
In this study, a facile one-step redox polymerization method for the preparation of highly dispersed palladium (Pd)/polypyrrole (PPy) nanocapsules has been demonstrated. During the polymerizaion proce...Read More
p-Aminophenol-induced cytotoxicity in Jurkat T cells: protective effect of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid.
Acetaminophen (APAP) is hepatotoxic and can cause toxicity in Jurkat T cells. p-Aminophenol (PAP), an industrial chemical and APAP metabolite, is nephrotoxic and hepatotoxic. Its potential toxicity in...Read More
Bimetallic nanoparticles are considered the next generation of nanocatalysts with increased stability and catalytic activity. Bio-supported synthesis of monometallic nanoparticles has been proposed as...Read More
Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes
We investigated the biotransformation of the oxidative arylamine (AA) hair dye ingredients [^1^4C]-para-aminophenol (PAP) and [^1^4C]-para-phenylenediamine (PPD) in reconstructed human epidermis and h...Read More
Three patients with acetaminophen overdose were observed to have dark-brown urine at an early stage of their illness. Subsequently, acute anuric renal failure and hepatic dysfunction developed in all ...Read More
The preactivated cyclophosphamide analogue, 4-HC, does not require activation by hepatic microsomal enzymes to express its cytotoxic activity and therefore, unlike cyclophosphamide, may be useful for ...Read More
[Quantitative determination of blood loss from the gastrointestinal tract using Metol in chronic diseases of the digestive organs].
The authors have developed a method for measuring the blood loss with feces using an available and inexpensive reagent--methyl-4-aminophenol sulphate (Metol). The diagnostic value of the method in ulc...Read More
Competitive heterogeneous enzyme immunoassay for theophylline by flow-injection analysis with electrochemical detection of p-aminophenol.
A competitive enzyme-linked immunoabsorbent assay based on the flow-injection amperometric detection of p-aminophenol has been investigated with use of the materials and general procedure of a commerc...Read More
Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ...Read More
Para-aminophenol and structurally related compounds as intermediates in lipofuscin formation and in renal and other tissue toxicities.
P-aminophenol is considered a minor nephrotoxic metabolite of phenacetin and acetaminophen (paracetamol) in man. Our experiments show that p-aminophenol readily undergoes oxidative polymerization duri...Read More
Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.
Aniline (in the form of its hydrochloride) has been shown to induce a rather rare spectrum of tumors in the spleen of Fischer 344 rats. The dose levels necessary for this carcinogenic activity were in...Read More
Development of a heterogeneous amperometric immunosensor for the determination of apolipoprotein E in serum.
Apolipoprotein (apo) E is a constituent of serum lipoproteins and can serve as a diagnostic parameter for the assessment of disorders of lipid metabolism. For the determination of apo E in serum a san...Read More
Heterogeneous enzyme immunoassay of alpha-fetoprotein in maternal serum by flow-injection amperometric detection of 4-aminophenol.
A sandwich-type heterogeneous enzyme immunoassay with flow-injection analysis for alpha-fetoprotein (AFP) in human serum has been developed. 4-Aminophenol, the product of enzymatic reaction, is detect...Read More
Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with ^2-amyloid, acetylcholine, and butyrylcholine esterases
Approved drugs for the treatment of Alzheimer's disease belong to the group of inhibitors of the acetylcholinesterase (AChE) and NMDA receptor inhibitors. However none of the drugs is able to com...Read More
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Amine-functionalized polyglycidyl methacrylate microsphere as a unified template for the synthesis of gold nanoparticles and single-crystal gold plates.
Polyglycidyl methacrylate (PGMA) microspheres, crosslinked and surface-functionalized by amine, can be used as a solid-state template for the synthesis of gold (Au) crystals in the forms of either nan...Read More
Nanoaggregates of a pentacenequinone derivative as reactors for the preparation of palladium nanoparticles.
Fluorescent nanoaggregates of pentacenequinone derivative serve as reactors for the preparation of palladium nanoparticles in aqueous medium. Further, the combination of catalytic quantities of palla...Read More