展开

甘氨酸

产品编号 A110750 | CAS号 56-40-6 | 阿拉丁
Aminoacetic acid
分析标准品
组合的产品项目
货号 规格 库存 价格 数量
A110750-250mg 分析标准品 上海(>10)
北方(>10)
 
客户看了后又看了下面的产品

属性

密度 1.0300
熔点 182°C
沸点 233°C
溶解性 易溶于水,在水中的溶解度:25℃时为25g/100ml;50℃时为39.1g/100ml;75℃时为54.4g/100ml;100℃时为67.2g/100ml。极难溶于乙醇,在100g无水乙醇中约溶解0.06g。几乎不溶于丙酮和乙醚。
存贮条件 密封保存

描述

产品介绍 味甜。溶于水,微溶于吡啶,不溶于乙醚。25℃,100ml水中溶解度为25.0g,50℃为39.1g,75℃为54.4g,100℃为67.2g。热至233℃开始分解,290℃全部结块。最小致死量(猫,静脉)3000mg/kg。
别名 甘氨酸 ;氨基乙酸,氨基醋酸 ;Glycine Aminoethanoic acid Glycocoll Amino acetic acid Gly
应用 络合滴定指示剂,色层分析用试剂;缓冲剂;比色法测定氨基酸时作标准用。检验铜、金和银。制备组织培养基。在有机合成和生物化学中用作生化试剂和溶剂。
脊髓抑制性神经递质,NMDA受体的变构调节
分子生物学级用做缓冲液组分,在耦联磷酸激酶反应中用于末端标记限制性酶切片段;Tris -甘氨酸缓冲液组分,用于SDS -聚丙烯酰胺凝胶电泳中的体外翻译产物应用中。
编写您自己的评论
只有注册的用户才可以写评论。请 登录 创建帐户
安全声明(欧洲) S22;S24/25
个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS MB7600000
WGK德国 1
参考文献
A Guerra, N E Campillo, J A Páez
A neural model based on a numerical molecular representation using CODES program to predict oral absorption of any structure is described. This model predicts both high and low-absorbed compounds with...Read More
Mark G MG Jones, Elizabeth E Cooper, Saira S Amjad, C Stewart CS Goodwin, Jeffrey L JL Barron, Ronald A RA Chalmers
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified ...Read More
J R Bales, D P Higham, I Howe, J K Nicholson, P J Sadler
Numerous low-Mr metabolites--including creatinine, citrate, hippurate, glucose, ketone bodies, and various amino acids--have been identified in 400- and 500-MHz proton nuclear magnetic resonance (1H N...Read More
Kevin Guo, Liang Li
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ...Read More
David S DS Wishart, Craig C Knox, An Chi AC Guo, Roman R Eisner, Nelson N Young, Bijaya B Gautam, David D DD Hau, Nick N Psychogios, Edison E Dong, Souhaila S Bouatra, Rupasri R Mandal, Igor I Sinelnikov, Jianguo J Xia, Leslie L Jia, Joseph A JA Cruz, Emi
The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...Read More
Balvinder S Vig, Terry R Stouch, Julita K Timoszyk, Yong Quan, Doris A Wall, Ronald L Smith, Teresa N Faria
The human intestinal oligopeptide transporter (PEPT1) facilitates the absorption of dipeptides, tripeptides, and many peptidomimetic drugs. In this study, a large number of peptides were selected to i...Read More
Susan E Logue, Mohamed Elgendy, Seamus J Martin
Apoptosis is a mode of programmed cell death that is widely used to eliminate cells during development, tissue homeostasis, infection or in response to injury. Alterations to the plasma membranes of a...Read More
Iris I Thondorf, Valerie V Voigt, Sarah S Sch?fer, Sabine S Gebauer, Katja K Zebisch, Linda L Laug, Matthias M Brandsch
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...Read More
Naomi L NL Kruhlak, Sydney S SS Choi, Joseph F JF Contrera, James L JL Weaver, James M JM Willard, Kenneth L KL Hastings, Lawrence F LF Sancilio
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...Read More
Sarah F SF Wilson, Christopher A CA James, Xiaochun X Zhu, Mike T MT Davis, Mark J MJ Rose
An LC-MS/MS method using pre-column derivatization with phenylisothiocyanate (PITC) was developed to quantify glycine in human cerebrospinal fluid (CSF) and applied to the determination of glycine in ...Read More
Arun Sreekumar, Laila M Poisson, Thekkelnaycke M Rajendiran, Amjad P Khan, Qi Cao, Jindan Yu, Bharathi Laxman, Rohit Mehra, Robert J Lonigro, Yong Li, Mukesh K Nyati, Aarif Ahsan, Shanker Kalyana-Sundaram, Bo Han, Xuhong Cao, Jaeman Byun, Gilbert S Omenn,
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...Read More
Doris M DM Jacobs, Laura L Spiesser, Maxime M Garnier, Niels N de Roo, Ferdi F van Dorsten, Boudewijn B Hollebrands, Ewoud E van Velzen, Richard R Draijer, John J van Duynhoven
NMR-based metabolite profiling of urine is a fast and reproducible method for detection of numerous metabolites with diverse chemical properties. However, signal overlap in the (1)H NMR profiles of hu...Read More
Nikolaos G NG Psihogios, Irene F IF Gazi, Moses S MS Elisaf, Konstantin I KI Seferiadis, Eleni T ET Bairaktari
NMR-based metabonomic analysis is a well-established approach to characterizing healthy and diseased states. The aim of this study was to investigate inter-individual variability in the metabolic urin...Read More
Sharon A Swanger, Yuncen A He, Joel D Richter, Gary J Bassell
Long-term synaptic plasticity involves changes in the expression and membrane insertion of cell-surface proteins. Interestingly, the mRNAs encoding many cell-surface proteins are localized to dendrite...Read More
Elaine F Walker, Robert Bonsall, Deborah J Walder
To examine plasma cortisol, adrencorticotropin hormone, and indicators of catecholamine activity in monozygotic twins discordant for schizophrenia or major affective disorders....Read More
Uriel U Heresco-Levy, Gali G Bar, Raz R Levin, Marina M Ermilov, Richard P RP Ebstein, Daniel C DC Javitt
Prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating, is decreased in schizophrenia. The validity of a glutamatergic, N-methyl-d-aspartate receptor (NMDAR)-mediated model ...Read More
A N Fonteh, R J Harrington, A Tsai, P Liao, M G Harrington
Our aim was to determine changes in free amino acid (FAA) and dipeptide (DP) concentrations in probable Alzheimer's disease (pAD) subjects compared with control (CT) subjects using liquid chromat...Read More
M A MA Lovell, W R WR Markesbery
Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overla...Read More
M L Selley, D R Close, S E Stern
There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation tha...Read More
J A JA Molina, F J FJ Jiménez-Jiménez, A A Hernánz, E E Fernández-Vivancos, S S Medina, F F de Bustos, C C Gómez-Escalonilla, Y Y Sayed
Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC), pyruvate-dehydrogenase complex (P...Read More
Takashi T Abe, Hideo H Tohgi, Chiaki C Isobe, Takahiko T Murata, Chigumi C Sato
To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measure...Read More
K J B?r, S Franke, B Wenda, S Müller, R Kientsch-Engel, G Stein, H Sauer
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels o...Read More
L L Hagenfeldt, L L Bjerkenstedt, G G Edman, G G Sedvall, F A FA Wiesel
Plasma and cerebrospinal fluid (CSF) concentrations of amino acids were measured in 65 healthy volunteers (50 men and 15 women). The CSF levels of the monoamine metabolites homovanillic acid (HVA), 3-...Read More
S S Engelborghs, B B Marescau, P P PP De Deyn
To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino ac...Read More
Beatrice B Bocca, Giovanni G Forte, Francesco F Petrucci, Anna A Pino, Francesca F Marchione, Giuseppe G Bomboi, Oreste O Senofonte, Franco F Giubilei, Alessandro A Alimonti
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were...Read More
M A MA Raskind, E R ER Peskind, C C Holmes, D S DS Goldstein
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid ...Read More
Jian-ping Jia, Jian-min Jia, Wei-dong Zhou, Min Xu, Chang-biao Chu, Xin Yan, Yong-xin Sun
An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons. It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylc...Read More
H U HU Shetty, H W HW Holloway, M B MB Schapiro
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several o...Read More
M O MO Kristensen, N C NC Gulmann, J E JE Christensen, K K Ostergaard, K K Rasmussen
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supp...Read More
Anna Walter, Ulrike Korth, Michael Hilgert, Joachim Hartmann, Oksana Weichel, Marion Hilgert, Klaus Fassbender, Andrea Schmitt, Jochen Klein
Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphoc...Read More
K Q Do, C J Lauer, W Schreiber, M Zollinger, U Gutteck-Amsler, M Cuénod, F Holsboer
HPLC and gas chromatography-mass spectrometry analyses of 18 amino acids, N-acetylaspartate, N-acetylaspartylglutamate, and 5-hydroxyindoleacetic acid, derived from serotonin, and homovanillic acid, d...Read More
K Kobayashi, Y Koide, K Yoshino, T Shohmori
Using reversed-phase high-performance liquid chromatography and electrochemical detection with a rapid one-step purification on Sephadex G-10 column, we have developed a sensitive technique to measure...Read More
C C H?rnryd, L L Bjerkenstedt, V E VE Grimm, G G Sedvall
The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction ...Read More
Sirpa S Rainesalo, Tapani T Ker?nen, Johanna J Palmio, Jukka J Peltola, Simo S SS Oja, Pirjo P Saransaari
Altered plasma and cerebrospinal fluid amino acid levels may be associated with human epilepsy. We studied three groups of patients, those with a generalized epileptic syndrome, juvenile myoclonic epi...Read More
Kenji K Hashimoto, Takeshi T Fukushima, Eiji E Shimizu, Naoya N Komatsu, Hiroyuki H Watanabe, Naoyuki N Shinoda, Michiko M Nakazato, Chikara C Kumakiri, Shin-ichi S Okada, Hisanori H Hasegawa, Kazuhiro K Imai, Masaomi M Iyo
The hypofunction of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors has been implicated in the pathophysiology of schizophrenia. Several lines of evidence suggest that D-serine may func...Read More
G G Alfredsson, F A FA Wiesel
Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 80...Read More
Wolfram W Gronwald, Matthias S MS Klein, Hannelore H Kaspar, Stephan R SR Fagerer, Nadine N Nürnberger, Katja K Dettmer, Thomas T Bertsch, Peter J PJ Oefner
Two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy is a fairly novel method for the quantification of metabolites in biological fluids and tissue extracts. We show in this contribution...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
Guifeng Kang, Ming Zhao, Xiaoyi Zhang, Li Peng, Chunbo Li, Wei Mao, Weidong Ye, Shiqi Peng
Aimed at the chemotherapy of chronic pain two kinds of analgesic pharmacophores, substituted purine and Gly-AA-OBzl, were coupled via a five-step-reaction procedure and 19 novel conjugates N-[2-chloro...Read More
Natasha Gilbert
We're sorry this abstract is currently not available....Read More
Fabio Leonardo Meza-Joya, Martha Patricia Ramírez-Pinilla, Jorge Luis Fuentes-Lorenzo
The aerial spraying of glyphosate formulations in Colombia to eradicate illegal crops has generated great concern about its possible impact on nontarget organisms, particularly amphibians. This study ...Read More
The use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites (aminomethylphosphonic acid) in food for human consumption and pose a threat to health. The...Read More
Hillary E HE Hoffman, Jana J Jirásková, Petr P Cígler, Miloslav M Sanda, Jan J Schraml, Jan J Konvalinka
Mammalian serine racemase (SR) is a pyridoxal-5'-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) re...Read More
Wolfram W Gronwald, Matthias S MS Klein, Raoul R Zeltner, Bernd-Detlef BD Schulze, Stephan W SW Reinhold, Markus M Deutschmann, Ann-Kathrin AK Immervoll, Carsten A CA B?ger, Bernhard B Banas, Kai-Uwe KU Eckardt, Peter J PJ Oefner
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used...Read More
C T CT Peng, K H KH Wu, S J SJ Lan, Jeffrey J P JJ Tsai, F J FJ Tsai, C H CH Tsai
Cerebrospinal fluid (CSF) amino acid concentrations were measured in 45 children with acute lymphoblastic leukemia (ALL). Central nervous system (CNS) disease was absent in 34 and present in 11 (Group...Read More
Shahid A SA Khan, I Jane IJ Cox, Gavin G Hamilton, Howard C HC Thomas, Simon D SD Taylor-Robinson
Nuclear magnetic resonance (NMR) spectroscopy is a non-invasive technique, which allows the study of cellular biochemistry and metabolism. It is a diverse research tool, widely used by biochemists to ...Read More
HCh Curtius, M Wolfensberger, U Redweik, W Leimbacher, RA Maibach, W Isler
A specific and very sensitive method for the determination of 5-hydroxy-tryptophol (5-HTOL) and 5-methoxytryptophol (5-MTOL) in extracts from human cerebrospinal fluid (CSF) involving the use of mass ...Read More
Luc A Cynober
The plasma concentration of an amino acid (AA) is the result of its rates of appearance (Ra) in and disappearance (Rd) from plasma. As for most nutrients, AA Ra and Rd are tightly regulated and at the...Read More
S Ishiwata, K Itoh, T Yamaguchi, N Ishida, M Mizugaki
To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mo...Read More
Ienaka Takeda, Cynthia Stretch, Pamela Barnaby, Kriti Bhatnager, Kathryn Rankin, Hao Fu, Aalim Weljie, Naresh Jha, Carolyn Slupsky
Saliva is a readily accessible biofluid that is important for the overall health, aiding in the chewing, swallowing, and tasting of food as well as the regulation mouth flora. As a first step to deter...Read More
Angelo Zinellu, Salvatore Sotgia, Elisabetta Pisanu, Bastianina Scanu, Manuela Sanna, Maria Franca Usai, Roberto Chessa, Luca Deiana, Ciriaco Carru
We're sorry this abstract is currently not available....Read More
Nikolaos Psychogios, David D Hau, Jun Peng, An Chi Guo, Rupasri Mandal, Souhaila Bouatra, Igor Sinelnikov, Ramanarayan Krishnamurthy, Roman Eisner, Bijaya Gautam, Nelson Young, Jianguo Xia, Craig Knox, Edison Dong, Paul Huang, Zsuzsanna Hollander, Theresa
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...Read More
J D JD Shoemaker, W H WH Elliott
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease...Read More
Valerio V Leoni, Thomas T Masterman, Fariba S FS Mousavi, Bengt B Wretlind, Lars-Olof LO Wahlund, Ulf U Diczfalusy, Jan J Hillert, Ingemar I Bj?rkhem
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed t...Read More
Anders A Jensen, Darius P Zlotos, Tommy Liljefors
The pharmacological properties of bisquaternary caracurine V, iso-caracurine V, and pyrazino[1,2-a;4,5-a']diindole analogues and of the neuromuscular blocking agents alcuronium and toxiferine I h...Read More
Silke S Hack, Babette B W?rlein, Georg G H?fner, J?rg J Pabel, Klaus T KT Wanner
A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been s...Read More
Richard C RC Grandison, Matthew D W MD Piper, Linda L Partridge
Dietary restriction extends healthy lifespan in diverse organisms and reduces fecundity. It is widely assumed to induce adaptive reallocation of nutrients from reproduction to somatic maintenance, aid...Read More
Stephan Urwyler, Philipp Floersheim, Bernard L Roy, Manuel Koller
Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or d-serine has proven to be difficult because in the vicinity of the alpha-amino acid...Read More
N A Strutyns'ka, N O Dorofeieva, H L Vavilova, V F Sahach
In experiments in vivo and in vitro on the mitochondria isolated from the control and spontaneously hypertensive rats (SHR) hearts, we studied the effects of a donor of hydrogen sulfide (H2S), NaHS, a...Read More
J K JK Nicholson, M P MP O'Flynn, P J PJ Sadler, A F AF Macleod, S M SM Juul, P H PH S?nksen
Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 4...Read More
Yanping Zhang, Hongxia Hao
Mutations in gap junction (GJ) family of proteins, especially in the connexin (Cx) 26, are responsible for causing severe congenital hearing loss in a significant portion of patients (30-50% in variou...Read More
Lei Xue, Jiansong Sheng, Xin-Sheng Wu, Wei Wu, Fujun Luo, Wonchul Shin, Hsueh-Cheng Chiang, Ling-Gang Wu
Studies over the last decade using FM dyes to label vesicles at many terminals, including the calyx-type nerve terminal, led to a well accepted "principle" that only a small fraction of vesi...Read More
I M Mykhe?tseva
We explored the melatonin influence on the level of amino acid neurotransmitters of the retina in glaucoma neuropathy in rats. Glaucoma was caused by the prolong systemic introduction of adrenalin. In...Read More
U K UK Laemmli
We're sorry this abstract is currently not available....Read More
Kenneth K Smith, Lori L Garman, Jens J Wrammert, Nai-Ying NY Zheng, J Donald JD Capra, Rafi R Ahmed, Patrick C PC Wilson
We describe herein a protocol for the production of antigen-specific human monoclonal antibodies (hmAbs). Antibody-secreting cells (ASCs) are isolated from whole blood collected 7 d after vaccination ...Read More
Deqiang Yu, Xiaojiao Shang, Raja Ghosh
PEGylation of therapeutic proteins can enhance their efficacy as biopharmaceuticals through increased stability and hydrophilicity, and decreased immunogenicity. A site-specific PEGylated protein (e.g...Read More
Margit Rosner, Nicol Siegel, Christiane Fuchs, Nina Slabina, Helmut Dolznig, Markus Hengstschl?ger
Human amniotic fluid stem cells (hAFSCs) are a very promising new type of fetal stem cells with numerous applications for basic science and cell-based therapies. They harbor a high differentiation pot...Read More
Ranveig R R?tterud, Per-Uno PU Malmstr?m, Rolf R Wahlqvist, Kristin A KA Taskén
To explore the use of two-dimensional gel electrophoresis (2DE) for analysing the proteome of clinically relevant tissue samples such as biopsies from transurethral resections of the bladder (TURB), b...Read More
Ronny V?lz, Juliane Heydlauff, Dagmar Ripper, Ludwig von Lyncker, Rita Gro?-Hardt
In flowering plants, sperm cells are delivered by pollen tubes, which are attracted by two egg-cell-adjoining synergids. Successful fertilization terminates pollen tube attraction; however, the underl...Read More
Bryn S Moore, Uyenlinh L Mirshahi, Tonya L Ebersole, Tooraj Mirshahi
Ionotropic glutamate receptor (iGluR) channels control synaptic activity. The crystallographic structure of GluA2, the prototypical iGluR, reveals a clamshell-like ligand-binding domain (LBD) that clo...Read More
Irina Smirnova, Vladimir Kasho, Junichi Sugihara, H Ronald Kaback
Trp replacements for conserved Gly-Gly pairs between the N- and C-terminal six-helix bundles on the periplasmic side of lactose permease (LacY) cause complete loss of transport activity with little or...Read More
Boris A Katsnelson, Tamara D Degtyareva, Larisa I Privalova, Ilzira A Minigaliyeva, Tatiana V Slyshkina, Vladimir V Ryzhov, Olga Yu Beresneva
Inhalation exposure of outbred female white rats (initial age about 4 months) to formaldehyde vapours (12.8 ± 0.69 mg/m(3)) 4h per day, 5 days per week during 10 weeks induced statistically significa...Read More
Ryan P Trump, Stefano Bresciani, Anthony W J Cooper, James P Tellam, Justyna Wojno, John Blaikley, Lisa A Orband-Miller, Jennifer A Kashatus, Mohamed Boudjelal, Helen C Dawson, Andrew Loudon, David Ray, Daniel Grant, Stuart N Farrow, Timothy M Willson, Ni
REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 ...Read More
The chronic stress in albino rats caused by exposure to the whole-body vibration induced the significant changes in the functional-metabolic status of the blood cells. It involved the phagocytosis lev...Read More
Joanne Euden, Sammy A Mason, Cedric Viero, N Lowri Thomas, Alan J Williams
Ryanodine receptor channels (RyR) are key components of striated muscle excitation-contraction coupling, and alterations in their function underlie both inherited and acquired disease. A full understa...Read More
Seth C Hopkins, Michele L R Heffernan, Lakshmi D Saraswat, Carrie A Bowen, Laurence Melnick, Larry W Hardy, Michael A Orsini, Michael S Allen, Patrick Koch, Kerry L Spear, Robert J Foglesong, Mustapha Soukri, Milan Chytil, Q Kevin Fang, Steven W Jones, Ma
We characterized the mechanism and pharmacodynamics of five structurally distinct inhibitors of d-amino acid oxidase. All inhibitors bound the oxidized form of human enzyme with affinity slightly high...Read More
Siddhesh S Kamat, Howard J Williams, Lawrence J Dangott, Mrinmoy Chakrabarti, Frank M Raushel
Methane is a potent greenhouse gas that is produced in significant quantities by aerobic marine organisms. These bacteria apparently catalyse the formation of methane through the cleavage of the highl...Read More
Laura Preiss, Adriana L Klyszejko, David B Hicks, Jun Liu, Oliver J Fackelmayer, Ozkan Yildiz, Terry A Krulwich, Thomas Meier
The c-rings of ATP synthases consist of individual c-subunits, all of which harbor a conserved motif of repetitive glycine residues (GxGxGxG) important for tight transmembrane α-helix packing. The c-...Read More
Nobuyuki Inoue, Norihiko Oka, Tadashi Kitamura, Ko Shibata, Keiichi Itatani, Takahiro Tomoyasu, Kagami Miyaji
Cardiopulmonary bypass (CPB) evokes activation of a systemic inflammatory response. Sivelestat has been used clinically to treat acute lung injury associated with systemic inflammatory response syndro...Read More
Jeremiah Stamler, Ian J Brown, Martha L Daviglus, Queenie Chan, Katsuyuki Miura, Nagako Okuda, Hirotsugu Ueshima, Liancheng Zhao, Paul Elliott
Available data have indicated independent direct relations of dietary animal protein and meat to the blood pressure (BP) of individuals.In this study, we aimed to assess whether BP is associated with ...Read More
Peter J Goldman, Tyler L Grove, Lauren A Sites, Martin I McLaughlin, Squire J Booker, Catherine L Drennan
Arylsulfatases require a maturating enzyme to perform a co- or posttranslational modification to form a catalytically essential formylglycine (FGly) residue. In organisms that live aerobically, molecu...Read More
Thomas Rückrich, Alexander Steinle
Cellular cytotoxicity is the hallmark of NK cells mediating both elimination of virus-infected or malignant cells, and modulation of immune responses. NK cytotoxicity is triggered upon ligation of var...Read More
Devon Andres, Brian M Keyser, John Petrali, Betty Benton, Kyle S Hubbard, Patrick M McNutt, Radharaman Ray
Immortalized neuronal cell lines can be induced to differentiate into more mature neurons by adding specific compounds or growth factors to the culture medium. This property makes neuronal cell lines ...Read More
Kasper B Hansen, Nami Tajima, Rune Risgaard, Riley E Perszyk, Lars J?rgensen, Katie M Vance, Kevin K Ogden, Rasmus P Clausen, Hiro Furukawa, Stephen F Traynelis
N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels assembled from GluN1 and GluN2 subunits. We used a series of N-hydroxypyrazole-5-glycine (NHP5G) partial agonists at the GluN2 gluta...Read More
A A Boneh, Y Y Degani, M M Harari
Nonketotic hyperglycinemia presenting in the neonatal period is considered a devastating neurological condition. Most patients die soon after birth, and those who survive manifest severe neurological ...Read More
Suzanne L Grant, Yanina Shulman, Philip Tibbo, David R Hampson, Glen B Baker
A simple and versatile methodology using high-performance liquid chromatography (HPLC) with fluorimetric detection was developed to simultaneously determine d-serine along with other metabolically rel...Read More
G R GR Christie, D D Ford, A A Howard, M A MA Clark, B H BH Hirst
Background & Aims: Intestinal glycine transport is involved in nutrient absorption and enterocyte homeostasis, particularly for glutathione synthesis. The primary aim of this study was to characte...Read More
J M JM Dicke, D D Verges, L K LK Kelley, C H CH Smith
Like most amino acids, glycine is present in higher concentrations in the fetus than in the mother. Unlike most amino acids, animal studies suggest fetal concentrations of glycine are minimally in exc...Read More
Jesús J Gomeza, Koji K Ohno, Swen S Hülsmann, Wencke W Armsen, Volker V Eulenburg, Diethelm W DW Richter, Bodo B Laube, Heinrich H Betz
The glycine transporter subtype 2 (GlyT2) is localized in the axon terminals of glycinergic neurons. Mice deficient in GlyT2 are normal at birth but during the second postnatal week develop a lethal n...Read More
Justin W Collins, Seamus Macdermott, Richard A Bradbrook, Frank X Keeley, Anthony G Timoney
To evaluate the utility of using a tracer of 1% ethanol in 1.5% glycine for the early detection of irrigation fluid absorption during transurethral resection of the prostate (TURP).In all, 126 men und...Read More
Andrew P Prescot, Blaise de B Frederick, Liqun Wang, John Brown, J Eric Jensen, Marc J Kaufman, Perry F Renshaw
A single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) method is described that enables the in vivo measurement of endogenous brain glycine (Gly) levels in human subjects. At 4.0 T, TE-avera...Read More
C M CM Jones, M M Smith, M J MJ Henderson
Cerebrospinal fluid (CSF) amino acid analysis is fundamental to the investigation of several inherited metabolic diseases, particularly those presenting with unexplained seizures. CSF glycine measurem...Read More
J L K JL Van Hove, K K Vande Kerckhove, J B JB Hennermann, V V Mahieu, P P Declercq, S S Mertens, M M De Becker, P S PS Kishnani, J J Jaeken
High-dose benzoate treatment aimed at reducing plasma glycine levels to normal reduces seizures and increases wakefulness in patients with nonketotic hyperglycinaemia (NKH). Since benzoate metabolism ...Read More
Eric J Dimise, Paul F Widboom, Steven D Bruner
Bacteria belonging to the order Actinomycetales have proven to be an important source of biologically active and often therapeutically useful natural products. The characterization of orphan biosynthe...Read More
Eva S ES Schaffert, Georg G H?fner, Klaus T KT Wanner
1,5-Disubstituted and 5-monosubstituted aminomethyltetrazole derivatives derived from glycine were synthesized employing a TMSN(3)-modified variant of the Ugi reaction as a key step. All compounds wer...Read More
B B López-Corcuera, A A Geerlings, C C Aragón
Glycine accomplishes several functions as a transmitter in the central nervous system (CNS). As an inhibitory neurotransmitter, it participates in the processing of motor and sensory information that ...Read More
Ilaria I Palchetti, Serena S Laschi, Marco M Mascini
In recent years, electrochemical sensors and biosensors are becoming an accepted part of analytical chemistry since they satisfy the expanding need for rapid and reliable measurements. An area in whic...Read More
Benoit B Boivin, Ming M Yang, Nicholas K NK Tonks
Controlled production of reactive oxygen species leads to reversible oxidation of protein tyrosine phosphatases (PTPs) and has emerged as an important tier of regulation over phosphorylation-dependent...Read More
Whole-cell patch clamp recordings from isolated frog spinal cord neurons were made to study the desensitization of glycine-mediated currents. The decay phase of current induced by application of glyci...Read More
Maria Luisa ML Gelmi, Donato D Pocar, Guido G Pontremoli, Sara S Pellegrino, Ezio E Bombardelli, Gabriele G Fontana, Antonella A Riva, Walter W Balduini, Silvia S Carloni, Mauro M Cimino, Francis F Johnson
A novel class of 3-demethoxy-3-glycosylaminothiocolchicines (7) was prepared and tested for muscle relaxant activity. The syntheses were performed starting from the new 3-amino-3-demethoxythiocolchici...Read More
Maria Luisa ML Gelmi, Gabriele G Fontana, Donato D Pocar, Guido G Pontremoli, Sara S Pellegrino, Ezio E Bombardelli, Antonella A Riva, Walter W Balduini, Silvia S Carloni, Mauro M Cimino
New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on gamma-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present...Read More
X L Jin, V Chandrakanthan, H D Morgan, C O'Neill
A universal response to cellular stress is the expression of transformation-related protein 53 (TRP53). This transcription factor reduces cell proliferation and/or survival and is classed as a tumour ...Read More
Laura E McBreairty, Ross A McGowan, Janet A Brunton, Robert F Bertolo
Methionine is the main source of methyl groups that are partitioned to synthesize various methylated products including creatine, phosphatidylcholine (PC), and methylated DNA. Whether increased methyl...Read More