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顺式-乌头酸

产品编号 A111230 | CAS号 585-84-2 | 阿拉丁
cis-Aconitic acid
90%
组合的产品项目
货号 规格 库存 价格 数量
A111230-1g 90% 上海(预计3-7周)
北方(预计3-7周)
 
A111230-5g 90% 上海(预计3-7周)
北方(预计3-7周)
 
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属性

敏感性 对湿度敏感
密度 1.6600
熔点 130°C
存贮条件 储存温度-20°C

描述

产品介绍 是一种不饱和三羧酸,常以顺式存在。顺乌头酸熔点130℃,反乌头酸熔点194~195℃。首先在乌头属植物Aconitum napellus中发现。 有吸湿性。易溶于水和乙醇,微溶于乙 醚。加热易转化为反式。有毒。有致癌可能性。有刺激性
别名 顺-乌头酸;顺式-1,2,3-丙烯三羧酸;cis-Propene-1,2,3-tricarboxylic acid;(1Z)-Propene-1,2,3-tricarboxylic acid;(Z)-Aconitic acid
备注 长期储存可能形成反式异构体
应用 在生物体内顺乌头酸是柠檬酸在乌头酸酶(定位在线粒体内)作用下异构化生成异柠檬酸的中间产物,这一转变过程受氟乙酸抑制。氟乙酸(常用作灭鼠药)在体内转变为氟乙酰CoA,与草酰乙酸缩合成氟柠檬酸,后者抑制乌头酸酶,阻断柠檬酸转变为异柠檬酸,中止柠檬酸循环,造成致命的后果。
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标识符号 GHS08 GHS08
信号词 Warning
风险声明 (欧洲) 36/38,40
安全声明(欧洲) 26,36/37
警示性声明 P281
危害码(欧洲) Xn
危害声明 H351
WGK德国 1
参考文献
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The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...Read More
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This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requir...Read More
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Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...Read More
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NMR-based metabolite profiling of urine is a fast and reproducible method for detection of numerous metabolites with diverse chemical properties. However, signal overlap in the (1)H NMR profiles of hu...Read More
Olivier O Boulat, Marianne M Gradwohl, Vera V Matos, Jean-Pierre JP Guignard, Claude C Bachmann
Organic acid analysis is used for the early detection/ exclusion and for the follow-up of inherited disorders of amino acid and organic acid metabolism. Urinary organic acid concentrations in 417 heal...Read More
G F Hoffmann, W Meier-Augenstein, S St?ckler, R Surtees, D Rating, W L Nyhan
Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...Read More
F Guneral, C Bachmann
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...Read More
Wolfram W Gronwald, Matthias S MS Klein, Raoul R Zeltner, Bernd-Detlef BD Schulze, Stephan W SW Reinhold, Markus M Deutschmann, Ann-Kathrin AK Immervoll, Carsten A CA B?ger, Bernhard B Banas, Kai-Uwe KU Eckardt, Peter J PJ Oefner
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used...Read More
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We analyzed lactate, pyruvate, and citric acid cycle intermediates in cerebrospinal fluid by high-performance liquid chromatography in Rett syndrome patients (n = 27; mean age, 5.7 +/- 3.4 years) and ...Read More
J H Str?mme, O Borud, P J Moe
An infant suffering from metabolic acidosis attributable to hyperlactatemai (6.1 mmol/liter) accompanied by hyperalaninemia (1 mmol/liter) and hyperserinemia (0.6 mmol/liter) is described. The urinary...Read More

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