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N-(4-氨基甲酰)-L-谷氨酸

产品编号 A111243 | CAS号 4271-30-1 | 阿拉丁
N-(4-Aminobenzoyl)-L-glutamic acid
97%
组合的产品项目
货号 规格 库存 价格 数量
A111243-1g 97% 上海(>10)
北方(预计3-5个工作日)
 
A111243-25g 97% 上海(4)
北方(预计3-5个工作日)
 
A111243-5g 97% 上海(10)
北方(预计3-5个工作日)
 
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属性

密度 1.4180
熔点 173°C。

描述

产品介绍 能溶于水,微溶于醇,不溶于醚。
别名 N-(4-氨基甲酰)-L-谷氨酸 ;N-对氨基苯甲酰-L-谷氨酸,对氨基苯甲酰基麸质酸;N-(P-Aminobenzoyl)-L-glutamic acid
应用 医药中间体,用于甲氨喋呤、叶酸的生产。
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个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国 3
Merck Index 426
参考文献
M J Hussein, J M Green, B P Nichols
An Escherichia coli strain deficient in p-aminobenzoate synthesis was mutagenized, and derivatives were selected for growth on folic acid. Supplementation was shown to be due to p-aminobenzoyl-glutama...Read More
Eric L EL Carter, Lindsey L Jager, Lars L Gardner, Christel C CC Hall, Stacey S Willis, Jacalyn M JM Green
Escherichia coli AbgT was first identified as a structural protein enabling the growth of p-aminobenzoate auxotrophs on exogenous p-aminobenzoyl-glutamate (M. J. Hussein, J. M. Green, and B. P. Nichol...Read More
Jacalyn M Green, Ryan Hollandsworth, Lenore Pitstick, Eric L Carter
The abg locus of the Escherichia coli chromosome includes three genes encoding proteins (AbgA, AbgB, and AbgT) that enable uptake and utilization of the folate breakdown product, p-aminobenzoyl-glutam...Read More
J J Plocek, M V MV Novotny
A charged and strongly UV-absorbing tag, N-(4-aminobenzoyl)-l-glutamic acid) (ABG), was coupled to oligosaccharides by reductive amination under mild conditions. The effectiveness of ABG as a derivati...Read More
J F Gregory, J Williamson, J F Liao, L B Bailey, J P Toth
In a 10-wk study of folate metabolism in nonpregnant women (21-27 y, n -6 per group), subjects were fed a diet containing approximately 68 nmol/d (30 microg/d) folate from food. The remainder of the i...Read More
M A MA Caudill, J F JF Gregory, A D AD Hutson, L B LB Bailey
Measurement of the urinary folate catabolites, para-aminobenzoylglutamate (pABG) and the more predominant acetylated form, acetamidobenzoylglutamate (apABG), has been used to assess folate requirement...Read More
Guifeng Li, Donny Magana, R Brian Dyer
Conformational control of excited-state intramolecular electron transfer (ET) in folic acid (FA) has been investigated using femtosecond time-resolved infrared (TRIR) spectroscopy. Ultrafast excited-s...Read More
Regina S Scurachio, Leif H Skibsted, Gustavo Metzker, Daniel R Cardoso
Folate is shown to react with singlet-excited state of riboflavin in a diffusion controlled reaction and with triplet-excited state of riboflavin in a somewhat slower reaction with (3)k(q) = 4.8 × 10...Read More
M Laura ML Dántola, M Paula MP Denofrio, Beatriz B Zurbano, Carlos S CS Gimenez, Peter R PR Ogilby, Carolina C Lorente, Andrés H AH Thomas
Folic acid, or pteroyl-l-glutamic acid (PteGlu), is a precursor of coenzymes involved in the metabolism of nucleotides and amino acids. PteGlu is composed of three moieties: a 6-methylpterin (Mep) res...Read More
Sabine S M?nch, Michael M Netzel, Gabriele G Netzel, Michael M Rychlik
New stable isotope dilution assays were developed for the simultaneous quantitation of the folates 5-methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid, tetrahydrofolic acid, 10-formylfolic acid...Read More
R Hannisdal, P M Ueland, S J P M Eussen, A Svardal, S Hustad
Folate is not stable in serum and plasma. This may impair laboratory diagnostics and distort the outcome of epidemiological studies on folate and chronic diseases. The present study was designed to de...Read More
Rita R Hannisdal, Asbj?rn A Svardal, Per Magne PM Ueland
The development of accurate and precise folate assays has been difficult, mainly because of folate instability. Large interassay and interlaboratory differences have been reported. We therefore develo...Read More
Gale G GG Bozzo, Gilles J C GJ Basset, Valeria V Naponelli, Alexandre A Noiriel, Jesse F JF Gregory, Andrew D AD Hanson
Folate breakdown gives a p-aminobenzoylglutamate moiety that can be hydrolyzed to the folate precursor p-aminobenzoate. Subcellular fractionation and chromatography indicated that pea and Arabidopsis ...Read More
Giuseppe Orsomando, Gale G Bozzo, Rocío Díaz de la Garza, Gilles J Basset, Eoin P Quinlivan, Valeria Naponelli, Fabrice Rébeillé, Stéphane Ravanel, Jesse F Gregory, Andrew D Hanson
Folates in vivo undergo oxidative cleavage, giving pterin and p-aminobenzoylglutamate (pABAGlu) moieties. These breakdown products are excreted in animals, but their fate is unclear in microorganisms ...Read More
A A H Sokoro, M L Etter, J Lepage, B Weist, J Eichhorst, D C Lehotay
Objective: To develop a routine method for quantitative measurement of the folate catabolites p-aminobenzoylglutamate (pABG) and acetamidobenzoylglutamate (apABG) in serum and urine using liquid chrom...Read More
Yumei Y Lin, Stephen R SR Dueker, Jennifer R JR Follett, James G JG Fadel, Ali A Arjomand, Philip D PD Schneider, Joshua W JW Miller, Ralph R Green, Bruce A BA Buchholz, John S JS Vogel, Robert D RD Phair, Andrew J AJ Clifford
A quantitative understanding of human folate metabolism is needed....Read More
Vellappan V Kesavan, Madan S MS Pote, Vipen V Batra, Gomathy G Viswanathan
Concentrations of total folates and their oxidative degradate, para-aminobenzoyl glutamic acid, were determined in mouse after 2-7 Gy total body gamma-irradiation (TBI). Total liver folate levels were...Read More
Judith M JM Wolfe, Lynn B LB Bailey, Kelli K Herrlinger-Garcia, Douglas W DW Theriaque, Jesse F JF Gregory, Gail P A GP Kauwell
The major route of folate turnover is by catabolic cleavage of the C9-N10 bond producing p-aminobenzoylglutamate (pABG) and its primary excretory form, p-acetamidobenzoylglutamate (ApABG). We hypothes...Read More
Marie A MA Caudill, Lynn B LB Bailey, Jesse F JF Gregory
Folate catabolism represents the major route of folate turnover in humans and involves cleavage of the C9-N10 bond producing a pterin and para-aminobenzoylglutamate (pABG). Thus, the quantitation of p...Read More
J F JF Gregory, M A MA Caudill, F J FJ Opalko, L B LB Bailey
To investigate the effects of pregnancy on folate metabolism, we conducted an 84-d study in second-trimester (gestational wk 14-25) pregnant women (n = 6) and nonpregnant controls (n = 6) with stable-...Read More
J F Gregory, M E Swendseid, R A Jacob
Folate turnover involves urinary excretion, fecal excretion, and catabolism that involves cleavage of the C9-N10 bond to yield pterins and para-aminobenzoylglutamate (pABG). Little is known about the ...Read More
J R Higgins, E P Quinlivan, J McPartlin, J M Scott, D G Weir, M R Darling
To estimate the rate of folate catabolism in pregnant and nonpregnant women and to derive the recommended dietary allowance for folate....Read More
J R JR Suh, E W EW Oppenheim, S S Girgis, P J PJ Stover
We have identified and purified to homogeneity an enzyme from rat liver that catalyzes the oxidative catabolism of 5-formyltetrahydrofolate to p-aminobenzoylglutamate and a pterin derivative. Purifica...Read More
B Birdsall, V I Polshakov, J Feeney
In a series of complexes of Lactobacillus casei dihydrofolate reductase (DHFR) formed with substrates and substrate analogues, the (1)H/(15)N NMR chemical shifts for the guanidino group of the conserv...Read More
M J MJ Akhtar, M A MA Khan, I I Ahmad
A study of the photodegradation of folic acid by ultraviolet radiation in aqueous solution has been made. Folic acid is photolysed by an apparent first-order kinetics and the log k-pH profile shows a ...Read More
M M Payton, V V Smelt, A A Upton, E E Sim
Mice have three arylamine N-acetyltransferase (NAT) isoenzymes (NAT1, NAT2, and NAT3) of which NAT2 is known to be polymorphic. Humans have two polymorphic isoenzymes, NAT1 and NAT2. The isoenzymes mo...Read More

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