|产品介绍||水中溶解度: 7 W/W % 水(20°C)|
|别名||脒基硫脲 ;硫氰酸胍,2-亚氨基-4-硫化缩二脲 ;2-Imino-4-thiobiuret Aminoiminoethyl thiourea Guanylthiourea|
|个人防护设备||dust mask type N95 (US),Eyeshields,Gloves|
The survey deals with the up-to-date information in the literature on the problem of pharmacological correction of pathological changes found in the organism in the hypoxic syndrome. The principal app...Read More
Presents the results of many-year experimental studies, clinical trials, and medical use of drugs of a new pharmacological class: antihypoxants. Antihypoxants are perspective drugs of urgent medicine,...Read More
[Role of hypoxia factor in changes of ionic composition of blood and muscle tissue in experimental botulinum poisoning].
Levels of sodium and potassium ions in muscle tissue, blood plasma and red cells were measured, and the index characterizing the capacity of tissue to accumulate cations from the environment and the d...Read More
[Effect of using gutimine in the pre-ischemic period on myocardial phospholipids during reperfusion].
Physico-chemical properties of phospholipids were studied in heart muscle at postischemic period after preventive treatment with gutimine. Two administrations of the drug, as compared with its three t...Read More
S-allylgutimine has immunostimulant and tumor cell inhibitory activities. This complex action may be a result of the stimulation of IL-2 production. The effectiveness of immunotherapy depends on the u...Read More
[The use of sodium gamma-oxybutyrate and gutimine for decreasing metabolic disorders in the heart, caused by exotoxic shock in acetic acid poisoning].
Exotoxic shock was simulated in non-linear rat males anesthetized with barbital after intragastric administration of 70% acetic acid at a dose of 4 ml/kg using a gastric tube. Energy metabolism and th...Read More
The antihypoxants gutimine and amtisole, its cyclic derivative of 3.5-diamino-1,thia-2,4-diazole were tested for their effects on the activity of one of the most power-consuming functions of a nerve c...Read More
[Radiation protection of mice with hypoxic gas mixtures after administration of anti-hypoxic agents].
It is shown that such substances as gutimine, antizol and mexamine increases the resistance of animals to short-term breathing of gas mixtures containing 6 and 5% oxygen. Even if some of them decrease...Read More
Redox-reactions of flavine (FN) and pyridine (PN) nucleotides of the cell to guthimine were studied by the method of fluorescent microscopy without using any stains. The comparison was made of the kin...Read More
[Prevention of post-resuscitation impairment of energy metabolism in the myocardium using sodium gamma-hydroxybutyrate, ionol and gutimine].
Long-term impairments of energy metabolisms in myocardium were found in rats after clinical death caused by acute hemorrhage. Bioenergetics of myocardium tended to normalize within a month after resus...Read More
A one-time addition of gutimine (0.5 g/l), amtizol (0.2 g/l), and unithiol (0.25 g/l) to the medium at early stages of tadpole development was shown to inhibit metamorphosis only upon addition of unit...Read More
[Effect of antioxidants of the gutimine group on the course and outcome of the post-resuscitation process].
The study of survival and life span of mice and white rats upon the administration of LD50 of the toxin has shown that an antihypoxic agent--gutimine (50-200 mg/kg)--had a protecting effect in type C ...Read More
[Effect of pharmacologic preparations on the electrical activity of cerebellar slices under hypoxia].
The effects of some antihypoxants (piracetam, GABA, sodium hydroxybutyrate and gutimine) on the electrical activity of the cerebellar neurons (Purkinje cells) of rats and mice were studied in the surv...Read More
Antihypoxic and antioxidant effects of exogenous succinic acid and aminothiol succinate-containing antihypoxants.
Pronounced antihypoxic and antioxidant effects of preventive injection of succinic acid, aminothiol antihypoxants gutimine and amtizol, and succinate-containing aminothiol antihypoxants gutimine succi...Read More
Electronic structure analysis of guanylthiourea (GTU) and its isomers has been carried out using quantum chemical methods. Two major tautomeric classes (thione and thiol) have been identified on the p...Read More
The effects of antihypoxants gutimine and amtisole on oxygen consumption by the intact nerve cell of the invertebrate and the activity of NADN-DH and SDH-dependent ways of oxidation in the cell were s...Read More
To measure drug antihypoxic activity, an electromyographic method was worked out. The main idea of the method is to estimate the influence of these substances on the amplitude of slow electric waves o...Read More
Effect of acute lethal blood loss on character and frequency of cardiac arrhythmias in postresuscitation period has been studied. Experiments were carried out on mongrel male rats resuscitated after 4...Read More
The Fourie EEG spectral analysis of thr sensomotor cortex and dorsal hypocampus in freely moving rats could reveal the common pharmacological EEG effects of different antihypoxic agents (gutimin, amti...Read More