展开

4-氨基联苯

¥ 97.00

产品编号 A112677 | CAS号 92-67-1 | 阿拉丁
4-Aminobiphenyl
98%
组合的产品项目
货号 规格 库存 价格 数量
A112677-1g 98% 上海(>10)
北方(预计3-5个工作日)
 
A112677-25g 98% 上海(预计3-5个工作日)
北方(预计3-5个工作日)
 
A112677-5g 98% 上海(>10)
北方(预计3-5个工作日)
 
客户看了后又看了下面的产品

属性

敏感性 对光敏感
密度 1.0770
熔点 53°C
沸点 302°C
存贮条件 密封避光保存。

描述

产品介绍 能随水蒸气挥发。易溶于热水,溶于乙醇、乙醚、氯仿和甲醇,微溶于水冷水。中等毒,半数致死量(大鼠,经口)500mg/kg。有致癌可能性。
别名 4-氨基联苯 ;对氨基联苯,对苯基苯胺,联苯-4-胺 ;4-Biphenylamine 4-Biphenylylamine 4-Phenylaniline
生化机理 实验动物模型中肝肿瘤引发剂。
应用 测定硫酸盐。制造染料。癌症研究。有机合成。
?诱导人膀胱癌细胞和小鼠膀胱组织DNA损伤(致癌物质)
?合成富集的胺配体,折耗及水蛭蛋白的一步纯化
编写您自己的评论
只有注册的用户才可以写评论。请 登录 创建帐户
标识符号 GHS07 GHS07, GHS08 GHS08
信号词 Danger
风险声明 (欧洲) 45,22
安全声明(欧洲) 53,45
警示性声明 P201,P308+P313
危害码(欧洲) T
危害声明 H302,H350
个人防护设备 Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS DU8925000
WGK德国 3
闪点(摄氏) 113 °C
是否危化品 一般危险品
UN代码 3259
参考文献
V G Vaidyanathan, Lifang Xu, Bongsup P Cho
We used surface plasmon resonance (SPR) to characterize the binding interactions between the exonulease-free Klenow fragment (Kf-exo(-)) and unmodified and modified dG adducts derived from arylamine c...Read More
Jean Bendaly, Mark A Doll, Lori M Millner, Kristin J Metry, Ned B Smith, William M Pierce, David W Hein
Aromatic amines such as 4-aminobiphenyl (ABP) require biotransformation to exert their carcinogenic effects. Genetic polymorphisms in biotransformation enzymes such as N-acetyltransferase 2 (NAT2) may...Read More
Mariko Murata, Shosuke Kawanishi
Most arylamines are pro-carcinogens, and require metabolic activation to yield ultimate carcinogen metabolites. O-Acetylation of the N-hydroxy form of an arylamine yields an acetoxyarylamine, which ca...Read More
Vipin Jain, Benjamin Hilton, Bin Lin, Satyakam Patnaik, Fengting Liang, Eva Darian, Yue Zou, Alexander D Mackerell, Bongsup P Cho
The environmental arylamine mutagens are implicated in the etiology of various sporadic human cancers. Arylamine-modified dG lesions were studied in two fully paired 11-mer duplexes with a -G*CN- sequ...Read More
Thomas Schettgen, K Heinrich, T Kraus, Monika Gube
The personal use of hair dye products is currently under discussion due to the potentially increased risk of bladder cancer among long-time users described in epidemiological literature. In order to i...Read More
Shuang S Wang, Kim S KS Sugamori, Debbie D Brenneman, Ivy I Hsu, Adriana A Calce, Denis M DM Grant
One model for cancer initiation by 4-aminobiphenyl (ABP) involves N-oxidation by cytochrome P450 CYP1A2 followed by O-conjugation by N-acetyltransferase(s) NAT1 and/or NAT2 and decomposition to a DNA-...Read More
Ewald Roemer, Matthias K Schorp, Jean-Jacques Piadé, Jeffrey I Seeman, Donald E Leyden, Hans-Juergen Haussmann
Sugars, such as sucrose or invert sugar, have been used as tobacco ingredients in American-blend cigarettes to replenish the sugars lost during curing of the Burley component of the blended tobacco in...Read More
Lori M Millner, Mark A Doll, Marcus W Stepp, J Christopher States, David W Hein
N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of electrophilic intermediates that r...Read More
Jae-In JI Yoon, Sang-In SI Kim, Stella S Tommasi, Ahmad A Besaratinia
Aromatic amines are a widespread class of environmental contaminants present in various occupational settings and tobacco smoke. Exposure to aromatic amines is a major risk factor for bladder cancer d...Read More
Dan Gu, Robert J Turesky, Yeqing Tao, Sophie A Langou?t, Gwendoline C Nauwela?rs, Jian-Min Yuan, Douglas Yee, Mimi C Yu
Some epidemiological investigations have revealed that frequent consumption of well-done cooked meats and tobacco smoking are risk factors for breast cancer in women. 2-Amino-1-methyl-6-phenylimidazo[...Read More
Lori M Millner, Mark A Doll, Jian Cai, J Christopher States, David W Hein
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). NAT1 catalyzes N-acetyla...Read More
Dirk Lindner, Stephen Smith, Claire Martin Leroy, Anthony R Tricker
This multicenter, observational study was conducted in three European countries (Germany, Switzerland, and the United Kingdom) to determine the exposure of adult cigarette smokers and nonsmokers to se...Read More
Joseph D Paonessa, Yi Ding, Kristen L Randall, Rex Munday, Dayana Argoti, Paul Vouros, Yuesheng Zhang
NF-E2-related factor 2 (Nrf2) is a major cytoprotective gene and is a key chemopreventive target against cancer and other diseases. Here we show that Nrf2 faces a dilemma in defense against 4-aminobip...Read More
Gwendoline Nauwelaers, Erin E Bessette, Dan Gu, Yijin Tang, Julie Rageul, Valérie Fessard, Jian-Min Yuan, Mimi C Yu, Sophie Langou?t, Robert J Turesky
DNA adduct formation of the aromatic amine, 4-aminobiphenyl (4-ABP), a known human carcinogen present in tobacco smoke, and the heterocyclic aromatic amines (HAAs), 2-amino-9H-pyrido[2,3-b]indole (Aα...Read More
Tiffany H Seyler, John T Bernert
The aromatic amine 4-aminobiphenyl (4-ABP) is present in tobacco smoke. In humans, it is also a known bladder carcinogen. We describe here a method for the quantification of total 4-ABP in urine using...Read More
Mark A Doll, Yu Zang, Timothy Moeller, David W Hein
Human populations exhibit genetic polymorphism in N-acetylation capacity, catalyzed by N-acetyltransferase 2 (NAT2). We investigated the relationship between NAT2 acetylator genotype and phenotype in ...Read More
Uzma U Shahab, Moinuddin, Saheem S Ahmad, Kiran K Dixit, S M Abbas SM Abidi, Khursheed K Alam, Asif A Ali
4-Aminobiphenyl, a known carcinogen, has many environmental sources like cigarette smoke, industrial waste, and so forth. It can be metabolized to form a potent mutagen, N-hydroxy-N-acetyl-4-aminobiph...Read More
Kim S Sugamori, Debbie Brenneman, Otto Sanchez, Mark A Doll, David W Hein, William M Pierce, Denis M Grant
The aromatic amine 4-aminobiphenyl (ABP) is a liver procarcinogen in mice, requiring enzymatic bioactivation to exert its tumorigenic effect. To assess the role of arylamine N-acetyltransferase (NAT)-...Read More
Francine F B?hm, Dagmar D Schmid, Stefan S Denzinger, Wolf F WF Wieland, Elmar E Richter
4-Aminobiphenyl (4-ABP) and o-toluidine are known human bladder carcinogens, but only 4-ABP-releasing DNA adducts are known....Read More
Tiffany H Seyler, Levi-Rose Reyes, John T Bernert
We describe here a hemoglobin adduct assay applied to an analysis of samples from smokers and nonsmokers. The assay includes a sensitive method for quantification of orthotoluidine 2-aminonaphthylene,...Read More
Matthias K Schorp, Donald E Leyden
Public health authorities worldwide have concluded that exposure to environmental tobacco smoke (ETS) causes diseases, including cancer, in adult nonsmokers. The arylamine, 4-aminobiphenyl (4-ABP), ha...Read More
Kristen L Randall, Dayana Argoti, Joseph D Paonessa, Yi Ding, Zachary Oaks, Yuesheng Zhang, Paul Vouros
Exposure to 4-aminobiphenyl (4-ABP), an environmental and tobacco smoke carcinogen that targets the bladder urothelium, leads to DNA adduct formation and cancer development [1]. Two major analytical c...Read More

质检报告(COA)

请输入批号: