|生化机理||丙氨酰二肽，可用于如ala-leu, ala-lys, ala-gly, ala-pro, ala-tyr 和 ala-phe的理化研究或评估二肽的分离技术。丙氨酰二肽也可用于研究细胞摄取机制，二肽的代谢或细胞生长补充。 L-丙氨酰甘氨酸是一种简单的营养的二肽，也可用于物理化学研究，如氢键和重金属的络合。|
Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...Read More
Infrared spectroscopy of the alanine dipeptide analog in liquid water with DFT-MD. Direct evidence for P(II)/beta conformations.
Following our previous work [J. Phys. Chem. B. Lett., 2009, 113, 10059], DFT-based molecular dynamics (DFTMD) simulations of 2-Ala peptide (i.e. Ac-Ala-NHMe dialanine peptide analog with methyl group ...Read More
Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.
Over the last years, considerable progress has been made for the identification and characterization of drug transporters, and several modeling studies have been undertaken to predict their effects on...Read More
Equilibrium constants for the adsorption of the first water molecule on six protonated dipeptides (Gly-Gly+H(+), Gly-Ala+H(+), Ala-Gly+H(+), Ala-Ala+H(+), Pro-Gly+H(+), and Gly-Trp+H(+)) have been mea...Read More
Selectivity of quadruplex DNA stationary phases toward amino acids in homodipeptides and alanyl dipeptides.
Series of dipeptides, including homodipeptides and alanyl dipeptides, were separated using quadruplex (G-quartet) DNA stationary phases in open-tubular capillary electrochromatography (OTCEC). The sta...Read More
Differential mobility spectrometry of isomeric protonated dipeptides: modifier and field effects on ion mobility and stability.
The ability to resolve isomeric protonated dipeptides was investigated with the new technique of differential ion mobility mass spectrometry that uses "modifier" molecules to enhance differe...Read More
Water-mediated conformations of the alanine dipeptide as revealed by distributed umbrella sampling simulations, quantum mechanics based calculations, and experimental data.
An exhaustive umbrella sampling simulation of the alanine dipeptide in solution is reported. The presence of stable Y conformations in solution is assessed by both quantum calculations and experimenta...Read More
Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation.
A validated 3D pharmacophore model was generated for a series of ACE inhibitory peptides, which consisted of five features (two hydrophobic functions, two hydrogen bond acceptors, and a negative ioniz...Read More
Preparation of platinum(IV) complexes with dipeptide and diimine. X-ray crystal structure and ^1^9^5Pt NMR spectra
We prepared platinum(IV) complexes containing dipeptide and diimine or diamine, the [PtCl(dipeptide-N,N,O)(diimine or diamine)]Cl complex, where -N,N,O means dipeptide coordinated as a tridentate chel...Read More
Theoretical 13C chemical shift, 14N, and 2H quadrupole coupling- constant studies of hydrogen bonding in L-alanylglycine dipeptide.
(13)C chemical shieldings and (14)N and (2)H electric field gradient (EFG) tensors of L-alanylglycine (L-alagly) dipeptide were calculated at RHF/6-31 + + G** and B3LYP/6-31 + + G** levels of theory r...Read More
The methodology for the incorporation of azaamino-acid residues into peptides synthesised by a solid-phase method has been extended to allow azaalanine peptides to be prepared. In this way, Ac-Leu-Ser...Read More
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Isolated renal brush border microvilli vesicles were employed to study the uptake of radiolabel from L-Ala. [3H]Gly and D-Ala.[3H]Gly as well as to determine the presence of dipeptidase activity. Micr...Read More
Bestatin, [(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]-L-leucine, a known inhibitor of aminopeptidases, is shown to be a potent linear competitive inhibitor (KI,2.7 nM) of a dipeptidase purified from...Read More
The CH-stretching vibrational CD (VCD) spectra of glycyl-L-alanine, L-alanylglycine, and L-alanyl-L-alanine have been studied at neutral, high, and low pH in D2O solution. The intense positive VCD ban...Read More
Natural disasters such as drought, extreme temperatures, and flooding can severely impact crop production. Understanding the metabolic response of crops threatened with these disasters provides insigh...Read More
Differential metabolic regulation governed by the rice SUB1A gene during submergence stress and identification of alanylglycine by 1H NMR spectroscopy.
Although the genetic mechanism of submergence survival for rice varieties containing the SUB1A gene has been elucidated, the downstream metabolic effects have not yet been evaluated. In this study, th...Read More
The transverse relaxation rate R"2 of single quantum coherences, the relaxation rate R"L"L"C of long-lived coherences (LLC), and the ratio R"2/R"L"L"C have been...Read More
Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear pola...Read More
We report the first observation of long-lived states (LLS) having lifetimes T(LLS) that exceed the corresponding spin-lattice relaxation times T(1) by more than a factor 6 in a protein. Slow diffusion...Read More
FT Raman and IR spectra of the crystallized biologically active molecule, l-alanylglycine (l-Ala-Gly) have been recorded and analyzed. The equilibrium geometry, bonding features and harmonic vibration...Read More
Carnosine (beta-alanyl-L-histidine) is a putative neurotransmitter and has a possible role in neuron-glia cell interactions. Previously, we reported that carnosine induced hyperactivity in chicks when...Read More
Peptides are increasingly used as pharmaceutical agents. Many small peptides are the essential compounds in biological systems. Direct chiral separation of dipeptide derivatives using 9-(2-carbazole) ...Read More
Silks are a widely studied class of naturally occurring structural proteins. Dragline spider silk, in particular, is considered to be nature's high-performance material due to its remarkable comb...Read More
Refined molecular and crystal structure of silk I based on Ala-Gly and (Ala-Gly)(2)-Ser-Gly peptide sequence.
The molecular and crystal structure of one of the crystalline modifications of Bombyx mori, silk I, was determined by x-ray diffraction method. Cell dimensions are essentially the same as those found ...Read More
Direct measurement indicates a slow cis/trans isomerization at the secondary amide peptide bond of glycylglycine.
Spectral differences between the cis and the trans isomer of a secondary amide peptide bond were used to follow the time course of the cis/trans isomerization of Gly-Gly, Gly-Ala, Ala-Gly, and Ala-Ala...Read More
Carbon-13 chemical shift anisotropy (CSA) tensors for various carbon sites of polypeptides, and for carbon sites in alpha-helical and beta-sheet conformations of poly-L-alanine, and polyglycine, are p...Read More
Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity.
Bacteriophage muralytic enzymes degrade the cell wall envelope of staphylococci to release phage particles from the bacterial cytoplasm. Murein hydrolases of staphylococcal phages phi11, 80alpha, 187,...Read More