|别名||对氨基联苯,对苯基苯胺,联苯-4-胺;4-Biphenylamine 4-Biphenylylamine 4-Phenylaniline|
Binary and ternary binding affinities between exonuclease-deficient Klenow fragment (Kf-exo(-)) and various arylamine DNA lesions characterized by surface plasmon resonance.
We used surface plasmon resonance (SPR) to characterize the binding interactions between the exonule...Read More
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.
Aromatic amines such as 4-aminobiphenyl (ABP) require biotransformation to exert their carcinogenic ...Read More
Most arylamines are pro-carcinogens, and require metabolic activation to yield ultimate carcinogen m...Read More
Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor.
The environmental arylamine mutagens are implicated in the etiology of various sporadic human cancer...Read More
Determination of 2,5-toluylenediamine (2,5-TDA) and aromatic amines in urine after personal application of hair dyes: kinetics and doses.
The personal use of hair dye products is currently under discussion due to the potentially increased...Read More
Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver.
One model for cancer initiation by 4-aminobiphenyl (ABP) involves N-oxidation by cytochrome P450 CYP...Read More
Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies.
Sugars, such as sucrose or invert sugar, have been used as tobacco ingredients in American-blend cig...Read More
Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.
N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N...Read More
Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice.
Aromatic amines are a widespread class of environmental contaminants present in various occupational...Read More
DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.
Some epidemiological investigations have revealed that frequent consumption of well-done cooked meat...Read More
NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of...Read More
Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study.
This multicenter, observational study was conducted in three European countries (Germany, Switzerlan...Read More
Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention.
NF-E2-related factor 2 (Nrf2) is a major cytoprotective gene and is a key chemopreventive target aga...Read More
DNA adduct formation of the aromatic amine, 4-aminobiphenyl (4-ABP), a known human carcinogen presen...Read More
The aromatic amine 4-aminobiphenyl (4-ABP) is present in tobacco smoke. In humans, it is also a know...Read More
Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.
Human populations exhibit genetic polymorphism in N-acetylation capacity, catalyzed by N-acetyltrans...Read More
4-Aminobiphenyl, a known carcinogen, has many environmental sources like cigarette smoke, industrial...Read More
Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.
The aromatic amine 4-aminobiphenyl (ABP) is a liver procarcinogen in mice, requiring enzymatic bioac...Read More
4-Aminobiphenyl (4-ABP) and o-toluidine are known human bladder carcinogens, but only 4-ABP-releasin...Read More
Analysis of 4-aminobiphenyl hemoglobin adducts in smokers and nonsmokers by pseudo capillary on-column gas chromatography- tandem mass spectrometry.
We describe here a hemoglobin adduct assay applied to an analysis of samples from smokers and nonsmo...Read More
Biomonitoring of smoke constituents: exposure to 4-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in nonsmokers and smokers.
Public health authorities worldwide have concluded that exposure to environmental tobacco smoke (ETS...Read More
An improved liquid chromatography-tandem mass spectrometry method for the quantification of 4-aminobiphenyl DNA adducts in urinary bladder cells and tissues.
Exposure to 4-aminobiphenyl (4-ABP), an environmental and tobacco smoke carcinogen that targets the ...Read More