产品编号 A141216 | CAS号 92-67-1 | 阿拉丁
  • 分子式 C12H11N
  • 分子量169.23
货号 规格 库存 价格 数量
A141216-1ml 1000μg/ml,溶于吹扫-捕集甲醇溶液中 上海(预计3-7周)


别名 对氨基联苯,对苯基苯胺,联苯-4-胺;4-Biphenylamine 4-Biphenylylamine 4-Phenylaniline
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V G Vaidyanathan, Lifang Xu, Bongsup P Cho
We used surface plasmon resonance (SPR) to characterize the binding interactions between the exonulease-free Klenow fragment (Kf-exo(-)) and unmodified and modified dG adducts derived from arylamine c...Read More
Jean Bendaly, Mark A Doll, Lori M Millner, Kristin J Metry, Ned B Smith, William M Pierce, David W Hein
Aromatic amines such as 4-aminobiphenyl (ABP) require biotransformation to exert their carcinogenic effects. Genetic polymorphisms in biotransformation enzymes such as N-acetyltransferase 2 (NAT2) may...Read More
Mariko Murata, Shosuke Kawanishi
Most arylamines are pro-carcinogens, and require metabolic activation to yield ultimate carcinogen metabolites. O-Acetylation of the N-hydroxy form of an arylamine yields an acetoxyarylamine, which ca...Read More
Vipin Jain, Benjamin Hilton, Bin Lin, Satyakam Patnaik, Fengting Liang, Eva Darian, Yue Zou, Alexander D Mackerell, Bongsup P Cho
The environmental arylamine mutagens are implicated in the etiology of various sporadic human cancers. Arylamine-modified dG lesions were studied in two fully paired 11-mer duplexes with a -G*CN- sequ...Read More
Thomas Schettgen, K Heinrich, T Kraus, Monika Gube
The personal use of hair dye products is currently under discussion due to the potentially increased risk of bladder cancer among long-time users described in epidemiological literature. In order to i...Read More
Shuang S Wang, Kim S KS Sugamori, Debbie D Brenneman, Ivy I Hsu, Adriana A Calce, Denis M DM Grant
One model for cancer initiation by 4-aminobiphenyl (ABP) involves N-oxidation by cytochrome P450 CYP1A2 followed by O-conjugation by N-acetyltransferase(s) NAT1 and/or NAT2 and decomposition to a DNA-...Read More
Ewald Roemer, Matthias K Schorp, Jean-Jacques Piadé, Jeffrey I Seeman, Donald E Leyden, Hans-Juergen Haussmann
Sugars, such as sucrose or invert sugar, have been used as tobacco ingredients in American-blend cigarettes to replenish the sugars lost during curing of the Burley component of the blended tobacco in...Read More
Lori M Millner, Mark A Doll, Marcus W Stepp, J Christopher States, David W Hein
N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of electrophilic intermediates that r...Read More
Jae-In JI Yoon, Sang-In SI Kim, Stella S Tommasi, Ahmad A Besaratinia
Aromatic amines are a widespread class of environmental contaminants present in various occupational settings and tobacco smoke. Exposure to aromatic amines is a major risk factor for bladder cancer d...Read More
Dan Gu, Robert J Turesky, Yeqing Tao, Sophie A Langou?t, Gwendoline C Nauwela?rs, Jian-Min Yuan, Douglas Yee, Mimi C Yu
Some epidemiological investigations have revealed that frequent consumption of well-done cooked meats and tobacco smoking are risk factors for breast cancer in women. 2-Amino-1-methyl-6-phenylimidazo[...Read More
Lori M Millner, Mark A Doll, Jian Cai, J Christopher States, David W Hein
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). NAT1 catalyzes N-acetyla...Read More
Dirk Lindner, Stephen Smith, Claire Martin Leroy, Anthony R Tricker
This multicenter, observational study was conducted in three European countries (Germany, Switzerland, and the United Kingdom) to determine the exposure of adult cigarette smokers and nonsmokers to se...Read More
Joseph D Paonessa, Yi Ding, Kristen L Randall, Rex Munday, Dayana Argoti, Paul Vouros, Yuesheng Zhang
NF-E2-related factor 2 (Nrf2) is a major cytoprotective gene and is a key chemopreventive target against cancer and other diseases. Here we show that Nrf2 faces a dilemma in defense against 4-aminobip...Read More
Gwendoline Nauwelaers, Erin E Bessette, Dan Gu, Yijin Tang, Julie Rageul, Valérie Fessard, Jian-Min Yuan, Mimi C Yu, Sophie Langou?t, Robert J Turesky
DNA adduct formation of the aromatic amine, 4-aminobiphenyl (4-ABP), a known human carcinogen present in tobacco smoke, and the heterocyclic aromatic amines (HAAs), 2-amino-9H-pyrido[2,3-b]indole (Aα...Read More
Tiffany H Seyler, John T Bernert
The aromatic amine 4-aminobiphenyl (4-ABP) is present in tobacco smoke. In humans, it is also a known bladder carcinogen. We describe here a method for the quantification of total 4-ABP in urine using...Read More
Mark A Doll, Yu Zang, Timothy Moeller, David W Hein
Human populations exhibit genetic polymorphism in N-acetylation capacity, catalyzed by N-acetyltransferase 2 (NAT2). We investigated the relationship between NAT2 acetylator genotype and phenotype in ...Read More
Uzma U Shahab, Moinuddin, Saheem S Ahmad, Kiran K Dixit, S M Abbas SM Abidi, Khursheed K Alam, Asif A Ali
4-Aminobiphenyl, a known carcinogen, has many environmental sources like cigarette smoke, industrial waste, and so forth. It can be metabolized to form a potent mutagen, N-hydroxy-N-acetyl-4-aminobiph...Read More
Kim S Sugamori, Debbie Brenneman, Otto Sanchez, Mark A Doll, David W Hein, William M Pierce, Denis M Grant
The aromatic amine 4-aminobiphenyl (ABP) is a liver procarcinogen in mice, requiring enzymatic bioactivation to exert its tumorigenic effect. To assess the role of arylamine N-acetyltransferase (NAT)-...Read More
Francine F B?hm, Dagmar D Schmid, Stefan S Denzinger, Wolf F WF Wieland, Elmar E Richter
4-Aminobiphenyl (4-ABP) and o-toluidine are known human bladder carcinogens, but only 4-ABP-releasing DNA adducts are known....Read More
Tiffany H Seyler, Levi-Rose Reyes, John T Bernert
We describe here a hemoglobin adduct assay applied to an analysis of samples from smokers and nonsmokers. The assay includes a sensitive method for quantification of orthotoluidine 2-aminonaphthylene,...Read More
Matthias K Schorp, Donald E Leyden
Public health authorities worldwide have concluded that exposure to environmental tobacco smoke (ETS) causes diseases, including cancer, in adult nonsmokers. The arylamine, 4-aminobiphenyl (4-ABP), ha...Read More
Kristen L Randall, Dayana Argoti, Joseph D Paonessa, Yi Ding, Zachary Oaks, Yuesheng Zhang, Paul Vouros
Exposure to 4-aminobiphenyl (4-ABP), an environmental and tobacco smoke carcinogen that targets the bladder urothelium, leads to DNA adduct formation and cancer development [1]. Two major analytical c...Read More