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卡特缩合剂

产品编号 B106161 | CAS号 56602-33-6 | Aladdin
BOP Reagent
98%
组合的产品项目
货号 规格 库存 价格 数量
B106161-100g 98% 上海(8)
北方(2)
 
B106161-25g 98% 上海(预计3-7周)
北方(>10)
 
B106161-500g 98% 上海(预计3-7周)
北方(预计3-7周)
 
B106161-5g 98% 上海(>10)
北方(1)
 
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属性

敏感性 对光和湿度敏感
熔点 135-140°C
溶解性 Soluble in water (hydrolyses), acetone, and dichloromethane.
存贮条件 储存温度2-8℃,充氩保存

描述

产品介绍 在甲醇中25mg/ml,溶液澄清。对光敏感;对潮湿敏感磷正离子型多肽缩合剂[1.2];内酯化及酯化试剂[3.4]
别名 1H-苯并三唑-1-基氧代三(二甲氨基)磷鎓 六氟磷酸盐;BOP 试剂;BOP 卡特缩合剂;1H-苯并三唑-1-基氧代三(二甲氨基)六氟磷酸磷 ;Castro's Reagent; 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate;
应用 Usually used as reagent for Peptide coupling,Synthesis of esters,Esterification of carboxylic acids,Plasmid CAN-encapsulating liposomes,Synthesis of magnolamide for antioxidative activity,Catalyst for preparation of 9-acridinecaroboxamide derivative.
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标识符号 GHS02 GHS02, GHS07 GHS07
信号词 Danger
风险声明 (欧洲) R44;R37/38
警示性声明 P210,P261
危害码(欧洲) Xi
危害声明 H228,H315,H335
个人防护设备 dust mask type N95 (US),Eyeshields,Gloves
WGK德国 3
UN代码 1325
参考文献
Zhiyun Z Du, Changliang C Ren, Ruijuan R Ye, Jie J Shen, Victor V Maurizot, Yujin Y Lu, Jian J Wang, Huaqiang H Zeng
We report here, for the first time, the BOP-mediated one-pot macrocyclization that is facilitated and guided by internally placed intramolecular H-bonds to allow for the highly selective formation of ...Read More
Eun Ju Oh, Jung-Wook Kim, Ji-Hyun Kong, Sung Ho Ryu, Sei Kwang Hahn
Agonistic and antagonistic peptides for formyl peptide receptor like 1 (FPRL1) receptor have been investigated as novel drug candidates for inflammatory diseases such as sepsis, asthma, and rheumatoid...Read More
Zhao-Kui ZK Wan, Sumrit S Wacharasindhu, Christopher G CG Levins, Melissa M Lin, Keiko K Tabei, Tarek S TS Mansour
An efficient "one-step" synthesis of cyclic amidines and guanidines has been developed. Treatment of cyclic amides and ureas with benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluor...Read More
Suyeal S Bae, Mahesh K MK Lakshman
A novel class of O6-(benzotriazol-1-yl)inosine as well as the corresponding 2'-deoxy derivatives can be conveniently prepared by a reaction between sugar-protected or -unprotected inosine or 2�...Read More
S J Kopytek, R F Standaert, J C Dyer, J C Hu
Chemically induced dimerization (CID) can be used to manipulate cellular regulatory pathways from signal transduction to transcription, and to create model systems for study of the specific interactio...Read More
M M Llinares, C C Devin, O O Chaloin, J J Azay, A M AM Noel-Artis, N N Bernad, J A JA Fehrentz, J J Martinez
Bombesin receptor antagonists are potential therapeutic agents due to their ability to act as inhibitors of cellular proliferation. On the basis of our hypothesis concerning the mechanism of action of...Read More
A A Fournier, A A Couvineau, M M Laburthe
Vasoactive intestinal peptide (VIP) was assembled on a polyacrylamide gel using a combination of the Boc and Fmoc peptide synthesis strategies. Before the synthesis, the polymeric matrix functionalize...Read More
J S McMurray, C A Lewis, N U Obeyesekere
Head-to-tail cyclization of peptides attached to insoluble supports by means of the side chains of aspartic acid or glutamic acid allows the rapid synthesis of cyclic peptides of widely varied amino a...Read More
A A Fournier, C T CT Wang, A M AM Felix
The BOP reagent [benzotriazol-l-yl-oxy-tris-(dimethylamino)phosphonium hexa-fluorophosphate] introduced by Castro et al. [Tetrahedron Lett. (1975) 14, 1219-1222] is ideally suited for solid phase pept...Read More
R R Steinauer, F M FM Chen, N L NL Benoiton
The influence of the amount and nature of the necessary tertiary amine on racemization attending the BOP-mediated coupling of N-benzyloxycarbonylglycyl-dipeptides has been examined by determining the ...Read More
H H Gausepohl, M M Kraft, R W RW Frank
To investigate side reactions during the activation of side chain unprotected asparagine in Fmoc-solid phase peptide synthesis the peptide Met-Lys-Asn-Val-Pro-Glu-Pro-Ser was synthesized using differe...Read More
M M Forest, A A Fournier
The model peptide TRH was successfully synthesized using benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent). The coupling reactions were carried out in N,N-dimethyl...Read More
R Seyer, A Aumelas, A Caraty, P Rivaille, B Castro
The coupling reagent (benzotriazol-1-yloxy)tris-(dimethylamino)phosphonium (BOP) hexafluorophosphate was tested in the synthesis of luliberin (LH-RH) with inexpensive classically protected Boc-amino a...Read More
Christopher G CG Levins, Zhao-Kui ZK Wan
We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SNAr substitution using phosphonium reagents (e.g., BOP). Th...Read More
A Nagy, B Szoke, A V Schally
A convenient synthetic method is described for the preparation of peptide-methotrexate (MTX) conjugates in which MTX is coupled selectively through the gamma-carboxyl group of its glutamic acid moiety...Read More
R R Téoule, R R Derbyshire, A A Guy, D D Molko, A A Roget
Benzotriazol-1-yl-oxy-tris (dimethylamino) phosphonium salts have been used as novel condensing agents to promote internucleotide bond formation in phosphotriester oligodeoxyribonucleotide synthesis. ...Read More
J P Briand, A Van Dorsselaer, B Raboy, S Muller
The complete ubiquitin molecule (76 residues) has been synthesized by the solid-phase method of Merrifield by using BOP as the coupling reagent. The crude product was purified by gel filtration, middl...Read More
J M JM Lacombe, F F Andriamanampisoa, A A AA Pavia
In this paper, we report the solid-phase synthesis of peptides containing O-phosphonoserine using BOP as coupling reagent. Commercially available Fmoc amino-acids linked to p-alkoxybenzyl resin were u...Read More