|溶解性||Soluble in water (hydrolyses), acetone, and dichloromethane.|
|别名||1H-苯并三唑-1-基氧代三(二甲氨基)磷鎓 六氟磷酸盐;BOP 试剂;BOP 卡特缩合剂;1H-苯并三唑-1-基氧代三(二甲氨基)六氟磷酸磷 ;Castro's Reagent; 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate;|
|应用||Usually used as reagent for Peptide coupling,Synthesis of esters,Esterification of carboxylic acids,Plasmid CAN-encapsulating liposomes,Synthesis of magnolamide for antioxidative activity,Catalyst for preparation of 9-acridinecaroboxamide derivative.|
|个人防护设备||dust mask type N95 (US),Eyeshields,Gloves|
We report here, for the first time, the BOP-mediated one-pot macrocyclization that is facilitated and guided by internally placed intramolecular H-bonds to allow for the highly selective formation of ...Read More
Signal transduction of hyaluronic acid-peptide conjugate for formyl peptide receptor like 1 receptor.
Agonistic and antagonistic peptides for formyl peptide receptor like 1 (FPRL1) receptor have been investigated as novel drug candidates for inflammatory diseases such as sepsis, asthma, and rheumatoid...Read More
An efficient "one-step" synthesis of cyclic amidines and guanidines has been developed. Treatment of cyclic amides and ureas with benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluor...Read More
A novel class of O6-(benzotriazol-1-yl)inosine as well as the corresponding 2'-deoxy derivatives can be conveniently prepared by a reaction between sugar-protected or -unprotected inosine or 2...Read More
Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate.
Chemically induced dimerization (CID) can be used to manipulate cellular regulatory pathways from signal transduction to transcription, and to create model systems for study of the specific interactio...Read More
Bombesin receptor antagonists are potential therapeutic agents due to their ability to act as inhibitors of cellular proliferation. On the basis of our hypothesis concerning the mechanism of action of...Read More
Synthesis of a hydrophilic affinity matrix for the purification of the vasoactive intestinal peptide receptor.
Vasoactive intestinal peptide (VIP) was assembled on a polyacrylamide gel using a combination of the Boc and Fmoc peptide synthesis strategies. Before the synthesis, the polymeric matrix functionalize...Read More
Influence of solid support, solvent and coupling reagent on the head-to-tail cyclization of resin-bound peptides.
Head-to-tail cyclization of peptides attached to insoluble supports by means of the side chains of aspartic acid or glutamic acid allows the rapid synthesis of cyclic peptides of widely varied amino a...Read More
Applications of BOP reagent in solid phase synthesis. Advantages of BOP reagent for difficult couplings exemplified by a synthesis of [Ala 15]-GRF(1-29)-NH2.
The BOP reagent [benzotriazol-l-yl-oxy-tris-(dimethylamino)phosphonium hexa-fluorophosphate] introduced by Castro et al. [Tetrahedron Lett. (1975) 14, 1219-1222] is ideally suited for solid phase pept...Read More
Studies on racemization associated with the use of benzotriazol-1-yl-tris (dimethylamino)phosphonium hexafluorophosphate (BOP).
The influence of the amount and nature of the necessary tertiary amine on racemization attending the BOP-mediated coupling of N-benzyloxycarbonylglycyl-dipeptides has been examined by determining the ...Read More
To investigate side reactions during the activation of side chain unprotected asparagine in Fmoc-solid phase peptide synthesis the peptide Met-Lys-Asn-Val-Pro-Glu-Pro-Ser was synthesized using differe...Read More
The model peptide TRH was successfully synthesized using benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent). The coupling reactions were carried out in N,N-dimethyl...Read More
The coupling reagent (benzotriazol-1-yloxy)tris-(dimethylamino)phosphonium (BOP) hexafluorophosphate was tested in the synthesis of luliberin (LH-RH) with inexpensive classically protected Boc-amino a...Read More
We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SNAr substitution using phosphonium reagents (e.g., BOP). Th...Read More
Selective coupling of methotrexate to peptide hormone carriers through a gamma-carboxamide linkage of its glutamic acid moiety: benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate activation in salt coupling.
A convenient synthetic method is described for the preparation of peptide-methotrexate (MTX) conjugates in which MTX is coupled selectively through the gamma-carboxyl group of its glutamic acid moiety...Read More
A novel class of condensing reagents in phosphodiester oligodeoxyribonucleotides synthesis. Application of the constituents of free terminal carboxy oxytocine gene.
Benzotriazol-1-yl-oxy-tris (dimethylamino) phosphonium salts have been used as novel condensing agents to promote internucleotide bond formation in phosphotriester oligodeoxyribonucleotide synthesis. ...Read More
Total chemical synthesis of ubiquitin using BOP reagent: biochemical and immunochemical properties of the purified synthetic product.
The complete ubiquitin molecule (76 residues) has been synthesized by the solid-phase method of Merrifield by using BOP as the coupling reagent. The crude product was purified by gel filtration, middl...Read More
Solid-phase synthesis of peptides containing phosphoserine using phosphate tert.-butyl protecting group.
In this paper, we report the solid-phase synthesis of peptides containing O-phosphonoserine using BOP as coupling reagent. Commercially available Fmoc amino-acids linked to p-alkoxybenzyl resin were u...Read More