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羧乙基锗倍半氧化物(GE 132)

产品编号 B107531 | CAS号 12758-40-6 | 阿拉丁
Bis(2-carboxyethylgermanium(IV) sesquioxide)
99.95%
组合的产品项目
货号 规格 库存 价格 数量
B107531-100g 99.95% 上海(预计3-7周)
北方(预计3-7周)
 
B107531-25g 99.95% 上海(3)
北方(预计3-5个工作日)
 
B107531-5g 99.95% 上海(>10)
北方(6)
 
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属性

熔点 320°C

描述

产品介绍 无味、不溶于乙醇、乙醚、可容于碱、水中最大溶解度为10.8g/L,饱和水溶液的PH=2.5~2.6。
别名 有机锗(Ge-132);复合锗丙酸;二羧乙基三氧化二锗;三氧化二双[2-羧乙基锗(IV)] ;GE 132; Bis(carboxyethylgermanium) sesquioxide; Propagermanium; Carboxyethylgermanium sesquioxide; Bis(carboxyethylgermanium sesquioxide); 3,3'-(1,3-Dioxo-1,3-digermoxanediyl)dipropionic acid
应用 复合锗丙酸有机锗即羧乙基锗倍半氧化物,亦称Ge-132。它是人参、灵芝等名贵中药里的重要而有效的成份,有机锗是制药,功能食品及美容化妆品的优质原料。
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个人防护设备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国 2
Merck Index 7795
参考文献
Michael Gliem, Anne Kathrin Mausberg, John-Ih Lee, Ioannis Simiantonakis, Nico van Rooijen, Hans-Peter Hartung, Sebastian Jander
Inflammation is increasingly viewed as a new therapeutic target in subacute stages of brain infarction. However, apart from causing secondary damage, inflammation could equally promote beneficial lesi...Read More
Takashi Nakamura, Miki Saito, Hisashi Aso
The organic germanium compound, Ge-132, has immune-modulating effects. We evaluated the symbiotic effects of Ge-132 with lactobacilli and oligosaccharide (LB/OS) on the immune responses of mice. The h...Read More
Kana Tsukuda, Masaki Mogi, Jun Iwanami, Li-Juan Min, Fei Jing, Kousei Oshima, Masatsugu Horiuchi
Angiotensin II type 1 (AT(1)) receptor blockers (ARBs) are known to prevent the onset of stroke and to attenuate neural damage. Additional beneficial effects of ARBs, independent of AT(1) receptor blo...Read More
Yukinori Tamura, Masayuki Sugimoto, Toshinori Murayama, Manabu Minami, Yuki Nishikaze, Hiroyuki Ariyasu, Takashi Akamizu, Toru Kita, Masayuki Yokode, Hidenori Arai
Adipose tissue inflammation induced by macrophage infiltration through the MCP-1/CCR2 pathway is considered to play a pivotal role in the development of visceral obesity and insulin resistance. In the...Read More
Boryana Konstantinova Popivanova, Feodora Ivanova Kostadinova, Kengo Furuichi, Mohamed M Shamekh, Toshikazu Kondo, Takashi Wada, Kensuke Egashira, Naofumi Mukaida
Accumulating evidence indicates the crucial contribution of chronic inflammation to various types of carcinogenesis, including colon carcinoma associated with ulcerative colitis and asbestosis-induced...Read More
Ming-Hsing Lin, Tzu-Sheng Hsu, Pei-Ming Yang, Meng-Yen Tsai, Tsong-Pyng Perng, Lih-Yuan Lin
The aim of this work is to compare the radiosensitizing effect between organic and inorganic germanium compounds and to investigate whether nanometer-sized germanium particles can act as radiosensitiz...Read More
Yukinori Tamura, Masayuki Sugimoto, Toshinori Murayama, Yukihiko Ueda, Hiroshi Kanamori, Koh Ono, Hiroyuki Ariyasu, Takashi Akamizu, Toru Kita, Masayuki Yokode, Hidenori Arai
Recently, adipose tissue inflammation induced by macrophage infiltration through MCP-1/C-C chemokine receptor-2 (CCR2) pathway is considered to play a role in the development of visceral obesity and i...Read More
Johann W Wiechers, Caroline L Kelley, Trevor G Blease, J Chris Dederen
We're sorry this abstract is currently not available....Read More
Guoqiang Shangguan, Feifei Xing, Xiaogang Qu, Jianhua Mao, Dan Zhao, Xuejian Zhao, Jinsong Ren
A series of Ge132 derivatives have shown enhanced antitumor activity. Previous studies suggest that DNA can be their primary target. Here we show direct evidence that two newly synthesized Ge132 deriv...Read More
Q Chen, H Yang
Inorganic germanium and carboxyethyl germanium sesquioxide (germanium-132) in health drinks were respectively determined by hydride generation-atomic fluorescence spectrometry (HG-AFS). The conditions...Read More
Yutaka Tsutsumi, Junji Tanaka, Hiroe Kanamori, Mio Musashi, Hiina Minami, Arata Fukushima, Hiroaki Yamato, Nobuyuki Ehira, Takahito Kawamura, Shinji Obara, Nobutaka Ogura, Masahiro Asaka, Masahiro Imamura, Nobuo Masauzi
Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses fr...Read More
Guizhen Jiang, Hiroko Matsumoto, Junichi Yamane, Noboru Kuboyama, Yoshiaki Akimoto, Akira Fujii
The effect of therapeutic agents on trabecular bone loss in the mandible was investigated in ovariectomized rats. Eighty-seven Wistar SPF female rats were ovariectomized (OVX) or given a sham operatio...Read More
Kiyoki Kitagawa, Takashi Wada, Kengo Furuichi, Hiroyuki Hashimoto, Yoshiro Ishiwata, Masahide Asano, Motohiro Takeya, William A Kuziel, Kouji Matsushima, Naofumi Mukaida, Hitoshi Yokoyama
Fibrosis is a hallmark of progressive organ diseases. Monocyte chemoattractant protein (MCP)-1, also termed as macrophage chemotactic and activating factor (MCAF/CCL2) and its receptor, CCR2 are presu...Read More
Bonnie J Kaplan, G Merrill Andrus, W Wesley Parish
The preceding paper reviewed the anticancer properties and safety of bis (2-carboxyethylgermanium) sesquioxide (CEGS). An examination of those data leads one to question why this information has not s...Read More
Bonnie J Kaplan, W Wesley Parish, G Merrill Andrus, J Steven A Simpson, Catherine J Field
This paper reviews the history, chemistry, safety, toxicity, and anticancer effects of the organogermanium compound bis (2-carboxyethylgermanium) sesquioxide (CEGS). A companion review follows, discus...Read More
Hiroaki Shimokawa, Yasuhiro Eto, Kenji Miyata, Kunio Morishige, Tadashi Kandabashi, Kouji Matsushima, Akira Takeshita
Although the importance of monocytes/macrophages in the pathogenesis of arteriosclerosis is widely accepted, effective and safe treatment to inhibit those inflammatory cells remains to be developed. I...Read More
Yasuhiro Eto, Hiroaki Shimokawa, Eriko Tanaka, Kunio Morishige, Masahiro Fuchigami, Yoshiro Ishiwata, Kouji Matsushima, Akira Takeshita
Macrophages play an important role in the pathogenesis of atherosclerosis, for which monocyte chemoattractant protein (MCP)-1 and CCR2 chemokine receptors may be involved. The authors have recently de...Read More
Tomoya Yamashita, Seinosuke Kawashima, Masanori Ozaki, Masayuki Namiki, Nobutaka Inoue, Ken-ichi Hirata, Mitsuhiro Yokoyama
Monocyte chemoattractant protein-1 (MCP-1), which binds to C-C chemokine receptor 2, has been implicated as the primary source of monocyte chemoattractant function in the early stages of atheroscleros...Read More
Y Liu, X Sun, B Li, J Wang
To detect the antiproliferation of carboxyethyl germanium sesquioxide (Ge-132) on fibroblasts of pterygium in vitro and try to find a potentially effective agent for treatment of primary pterygium and...Read More
Kousei Ohshima, Masaki Mogi, Hirotomo Nakaoka, Fei Jing, Jun Iwanami, Li-Juan Min, Kana Tsukuda, Harumi Kanno, Akiyoshi Ogimoto, Jitsuo Higaki, Masatsugu Horiuchi
Additional beneficial effects of angiotensin II type 1 (AT(1)) receptor blockers beyond AT(1) receptor blockade have been highlighted. Irbesartan is reported to act as an antagonist of the monocyte ch...Read More
Takashi Nakamura, Miki Saito, Yasuhiro Shimada, Haruhiko Fukaya, Yasuo Shida, Yoshihiko Tokuji
Poly-trans-[(2-carboxyethyl) germasesquioxane], Ge-132 is a water-soluble organic germanium compound. Oral intake of dietary Ge-132 changes fecal color and we attempted to identify the fecal red pigme...Read More
Hiroshi Kanamori, Takeshi Matsubara, Akira Mima, Eriko Sumi, Kojiro Nagai, Toshikazu Takahashi, Hideharu Abe, Noriyuki Iehara, Atsushi Fukatsu, Hiroshi Okamoto, Toru Kita, Toshio Doi, Hidenori Arai
Monocyte chemoattractant protein (MCP-1) is an important mediator for macrophage recruitment in atherosclerosis and various glomerulonephritis. However, the role of MCP-1 and its receptor CCR2 in the ...Read More
T Katakura, T Yoshida, M Kobayashi, D N Herndon, F Suzuki
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a major cause of sepsis in patients who are immunosuppressed by their burns. In this study, an immunological regulation of ...Read More
Kengo Furuichi, Takashi Wada, Yasunori Iwata, Kiyoki Kitagawa, Ken-Ichi Kobayashi, Hiroyuki Hashimoto, Yoshiro Ishiwata, Masahide Asano, Hui Wang, Kouji Matsushima, Motohiro Takeya, William A Kuziel, Naofumi Mukaida, Hitoshi Yokoyama
Examined were CCR2-deficient mice to clarify the contribution of macrophages via monocyte chemoattractant protein 1 (MCP-1 or CCL2)/CCR2 signaling to the pathogenesis of renal ischemia-reperfusion inj...Read More
Chisato Hirayama, Hiroshi Suzuki, Madoka Ito, Makoto Okumura, Toshitugu Oda
Although antiviral agents have been adopted for the management of chronic hepatitis B, they have only limited efficacy because of the underlying impaired immune status. Propagermanium, a hydrophilic p...Read More