|别名||苯醌;1,4-苯醌; 2,5-环己二烯-1,4-二酮;对醌;对苯二酮;1,4-Benzoquinone; 2,5-Cyclohexadiene-1,4-dione; p-Quinone; Quinone|
|个人防护设备||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
Removal of halo-benzoquinone (emerging disinfection by-product) precursor material from three surface waters using coagulation.
Halo-benzoquinones (HBQs) have been previously detected as disinfection by-products in chlorinated drinking water. The current work investigates the link between natural organic matter (NOM) character...Read More
Role of proton-coupled electron transfer in the redox interconversion between benzoquinone and hydroquinone.
Benzoquinone/hydroquinone redox interconversion by the reversible Os(dmb)(3)(3+/2+) couple over an extended pH range with added acids and bases has revealed the existence of seven discrete pathways. A...Read More
The cytotoxicity of four dental compounds, hydroquinone, benzoquinone, eugenol and phtharal towards human oral squamous cell carcinoma (OSCC) cell lines, normal human oral cells (gingival fibroblast, ...Read More
Comparison of the repair of DNA damage induced by the benzene metabolites hydroquinone and p-benzoquinone: a role for hydroquinone in benzene genotoxicity.
The human population is continually exposed to benzene due to its presence in complex environmental mixtures and exposure has been linked to a range of haematotoxic effects, including an increased ris...Read More
We're sorry this abstract is currently not available....Read More
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of ...Read More
Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular ar...Read More
Arenes and electron-deficient olefins can be oxidatively coupled through a biomimetic Pd(OAc)2-catalyzed transformation. C-H activation of the arene partner is effected under reaction conditions of lo...Read More
One of the barriers to the development of protein therapeutics is effective delivery to mammalian cells. The proteins must maintain a careful balance of polar moieties to enable administration and dis...Read More
Metallothionein is a ubiquitous metal binding protein that plays an important role in metal ion homeostasis and redox chemistry within cells. Mammalian metallothioneins bind a wide variety of metals i...Read More
A pentacenequinone derivative with aggregation-induced emission enhancement characteristics for the picogram detection of Fe(3+) ions in mixed aqueous media.
The binding behavior of nanoaggregates of pentacenequinone derivative 1 having thiophene groups has been investigated toward various cations (Fe(3+), Fe(2+), Pd(2+), Mg(2+), Cd(2+), Hg(2+), Ni(2+), Zn...Read More
A novel platform to study the photoinduced electron transfer at a dye-sensitized solid/liquid interface.
Photoinduced electron transfer with the electron donor-acceptor linked system of zinc-5,10,15,20-tetraphenylporphyrin (ZnTPP) as donor and benzoquinone (BQ) as acceptor was designed to mimic the elect...Read More
In vivo modification of tyrosine residues in recombinant mussel adhesive protein by tyrosinase co-expression in Escherichia coli.
ABSTRACT:In nature, mussel adhesive proteins (MAPs) show remarkable adhesive properties, biocompatibility, and biodegradability. Thus, they have been considered promising adhesive biomaterials for var...Read More
Cyclopropane-substituted allylic ethers react with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form oxocarbenium ions with no competitive ring cleavage. This reaction can be used for the preparation ...Read More
Inhibition of amyloid fibrillation of lysozyme by phenolic compounds involves quinoprotein formation.
Numerous phenolic compounds have been reported to have an inhibitory role on amyloid formation of proteins. The present study, utilizing lysozyme as a model system, examined the anti-amyloidogenic eff...Read More
We have developed an optical assay for NADH (Dihydronicotinamide adenine dinucleotide) based on the catalytic growth of gold-silver core-shell nanoparticles (Au-Ag-CSNPs). The nanoparticles were immob...Read More
NADPH oxidase Nox4 is expressed in a wide range of tissues and plays a role in cellular signaling by providing reactive oxygen species (ROS) as intracellular messengers. Nox4 oxidase activity is thoug...Read More
Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Quinone molecules are intracellular electron-transport carriers, as well as critical intra- and extracellular signals. However, transcriptional regulation of quinone signaling and its molecular basis ...Read More
Complex I is the first and largest enzyme of the respiratory chain and has a central role in cellular energy production through the coupling of NADH:ubiquinone electron transfer to proton translocatio...Read More
In vitro investigation of enhanced hemocompatibility and endothelial cell proliferation associated with quinone-rich polydopamine coating.
Recent investigations have demonstrated that polydopamine (PDA)-modified surfaces were beneficial to the proliferation of endothelial cells (ECs). In this work, PDA coated 316L stainless steels (316L ...Read More
Fabrication and characterization of a thermostable quinoprotein aldose sugar dehydrogenase immobilized electrode.
We fabricated a thermostable quinoprotein aldose sugar dehydrogenase (tPQQ-ASD derived from a hyperthermophilic archaeon Pyrobaculum aerophilum) immobilized electrode. The electrode was prepared by i...Read More
Attempts to block metabolism by incorporating a 9-fluoro substituent at the A-ring of compound 1 (SCH 900229) using electrophilic Selectfluor? led to an unexpected oxidation of the A-ring to give difl...Read More
Pentaquinone based probe for nanomolar detection of zinc ions: chemosensing ensemble as an antioxidant.
A pentaquinone based compound 3a has been synthesized which undergoes significant fluorescence enhancement in the presence of Zn(2+) ions with a detection limit up to nanomolar range in THF. Further, ...Read More
Using a method in which DNA adducts are discovered based on their conversion in a nucleotide form to phosphorimidazolides with isotopologue benzoylhistamines (or p-bromobenzoylhistamine) prior to dete...Read More
Biological activities of Pseudevernia furfuracea (L.) Zopf extracts and isolation of the active compounds.
Pseudevernia furfuracea (L.) Zopf (Parmeliaceae) is a common epiphytic lichen in the conifer-hardwood forest of Anatolia. This species is used in traditional medicine in Turkey as a treatment for woun...Read More
Liquid chromatography negative ion electrospray ionisation tandem mass spectrometry has been used for characterisation of naturally occurring prenylated fungal metabolites and synthetic derivatives. T...Read More
p-Benzoquinone-mediated amperometric biosensor developed with Psychrobacter sp. for toxicity testing of heavy metals.
A rapid and reliable p-benzoquinone-mediated amperometric biosensor (ToxTell) incorporated with Psychrobacter sp. to detect toxicities of heavy metal ions has been developed. This ToxTell biosensor re...Read More
Efficient synthesis of oxygenated terphenyls and other oligomers: sequential arylation reactions through phenol oxidation-rearomatization.
One by one: starting from simple phenols, a diverse series of oxygenated terphenyl compounds can be prepared in a concise and practical manner using sequential arylation reactions involving phenol oxi...Read More
The transient receptor potential ankyrin 1 (TRPA1) nonselective cation channel has a conserved function as a noxious chemical sensor throughout much of Metazoa. Electrophilic chemicals activate both i...Read More
Exposure to benzene was recently reported to lower the cytochrome P450 (CYP) content in phenobarbital-pretreated rats in vivo (Gut et al., Environ. Health Perspect. 104 (1996) 1211-1218). This study f...Read More
Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes.
Troglitazone, a new oral antidiabetic drug, is reported to be mostly metabolized to its conjugates and not to be oxidized by cytochrome P-450 (P-450) enzymes. Of fourteen cDNA-expressed human P-450 en...Read More
Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
Oxidative ring opening of troglitazone (TGZ)(1) a thiazolidine 2,4-dione derivative used for the treatment of type II diabetes mellitus, leads to the formation of a quinone metabolite. The formation o...Read More
The genotoxicity of benzoquinone (BQ), a toxic benzene metabolite, is greatly enhanced by the presence of fetal calf serum (FCS) in the incubation medium. The FCS effect is abolished by heat denaturat...Read More
Expression of NAD(P)H:quinone oxidoreductase 1 in HeLa cells: role of hydrogen peroxide and growth phase.
The aim of this work was to study the role of H(2)O(2) in the regulation of NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase, EC ) with relation to cell density of HeLa cells cultures and the fun...Read More
NAD(P)H:quinone oxidoreductase 1 (NQO1) participates in the detoxification of many environmental quinones and related compounds. Recent studies have suggested that individuals with a polymorphism in N...Read More
Decreased Apoptotic Response of Inclusion-Cell Disease Fibroblasts: A Consequence of Lysosomal Enzyme Missorting?
To better understand the role of lysosomes in apoptosis, we compared the responses to apoptotic stimuli of normal fibroblasts with those of inclusion cells (I-cells), i.e., fibroblasts with impaired f...Read More
Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage?
Peroxynitrite and nitrogen dioxide (NO2) are reactive nitrogen species that have been implicated as causal factors in neurodegenerative conditions. Peroxynitrite-induced nitration of tyrosine residues...Read More
Oxidized metabolites of dopamine, known as dopamine quinone derivatives, are thought to play a pivotal role in the degeneration of dopaminergic neurons. Although such quinone derivatives are usually p...Read More
Physiologically-based pharmacokinetics and molecular pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite in tumor-bearing mice.
A whole-body physiologically-based model was developed to describe the pharmacokinetics of the ansamycin benzoquinone antibiotic 17-(allylamino)-17-demethoxygeldanamycin (17AAG) and its active metabol...Read More
Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress.
Apoptosis was induced in human foreskin fibroblasts by the redox-cycling quinone naphthazarin (5,8-dihydroxy-1,4-naphthoquinone). Most of the cells displayed ultrastructure typical of apoptosis after ...Read More
Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity
Microsomal cytochrome P450 reductase catalyzes the one-electron transfer from NADPH via FAD and FMN to various electron acceptors, such as cytochrome P450s or to some anti-cancer quinone drugs. This r...Read More
The 6-hydroxydopa quinone-containing active site peptide from bovine serum amine oxidase has been found to be highly homologous to a segment of a cloned human kidney amiloride-binding protein (Barbry,...Read More
Troglitazone, a PPAR-gamma agonist, is a new drug for type 2 diabetes. The drug decreases blood glucose via enhancing insulin action. Recently Sankyo pharmaceutical company is warning severe hepatotox...Read More
Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.
Troglitazone (TGZ) was the first glitazone used for the treatment of type II diabetes mellitus. TGZ undergoes an oxidative chroman ring-opening reaction to form a quinone product. Recently, cytochrome...Read More