|别名||二苯甲酮;苯酮;Diphenyl ketone Diphenylmethanone|
|个人防护设备||dust mask type N95 (US), Eyeshields, Gloves|
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...Read More
Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorit...Read More
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of ...Read More
A benzodioxole derivative, 4-(2-(benzodioxol-5-yloxy)ethoxy)benzophenone (BPC2BDO), based on 4-hydroxybenzophenone and sesamol was synthesized, and used as a one-component Type II photoinitiator. The ...Read More
Photoclickable dendritic molecular glue: noncovalent-to-covalent photochemical transformation of protein hybrids.
A water-soluble dendron with a fluorescein isothiocyanate (FITC) fluorescent label and bearing nine pendant guanidinium ion (Gu(+))/benzophenone (BP) pairs at its periphery (Glue(BP)-FITC) serves as a...Read More
Benzophenone derivatives of pyrimidines as effective non-nucleoside inhibitors of wild-type and drug-resistant HIV-1 reverse transcriptase.
We're sorry this abstract is currently not available....Read More
Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins.
Trehalose dimycolates (TDMs) are the most abundant glycolipids found in the cell wall of Mycobacterium tuberculosis (M. tb). TDMs play an important role in the pathogenesis of M. tb yet the only known...Read More
In this paper we have studied the 4-hydroxyl-2,5dimethylphenyl-benzophenone. Also, it was analyzed the vibrational assignment (FT-IR and Raman) in conjunction with computational results. The conformat...Read More
Ionic liquid-based ultrasound-assisted dispersive liquid-liquid microextraction followed high-performance liquid chromatography for the determination of ultraviolet filters in environmental water samples.
In the present study, a rapid, highly efficient and environmentally friendly sample preparation method named ionic liquid-based ultrasound-assisted dispersive liquid-liquid microextraction (IL-USA-DLL...Read More
Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl).
Two benzophenone glucopyranosides have been isolated from the nut shell part of Mahkota Dewa. The structures were identified as 2,4',6-trihydroxy-4-methoxy-benzophenone-2-O-β-d-glucoside (Mahkos...Read More
Caught in a web: Photo-cross-linkable temperature-responsive polymer-based nanofiber webs have been synthesized that have the ability to capture, encapsulate, and release cells by dynamically transfor...Read More
An amperometric sensor for the determination of benzophenone in food packaging materials based on the electropolymerized molecularly imprinted poly-o-phenylenediamine film.
Benzophenone is one of the most commonly used photoinitiators of UV-cured inks on food packaging materials and can migrate into foodstuffs. In this study, an amperometric benzophenone sensor based on ...Read More
Metal-ion directed synthesis of N2O2 type chelate complexes of Ni(II), Cu(II) and Zn(II): spectral, thermal and single crystal studies.
A set of Ni(II), Cu(II) and Zn(II) complexes of Schiff base have been synthesized by one pot condensation reaction of 2-hydroxy-4-methoxybenzophenone with 1,3-diaminopropane in 1:2:1 molar ratio. They...Read More
Molecular modeling studies of the structural, electronic, and UV absorption properties of benzophenone derivatives.
Benzophenone derivatives (BZP), an important class of organic UV filters, are widely used in sunscreen products due to their ability to absorb in the UVA and UVB ranges. The structural, electronic, an...Read More
PLA nanoparticles coated with a β-cyclodextrin polymer shell: preparation, characterization and release kinetics of a hydrophobic compound.
The aim of this work was to incorporate a hydrophobic compound benzophenone (BP) into core-shell nanoparticles (NPs) and to study its release. The core of these NPs is based on polylactic acid (PLA) a...Read More
Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water.
Sunscreen compounds with added benefit of skin cancer prevention have both public and commercial interests. Our earlier study using the Epstein-Barr virus early antigen in vitro assay reported on skin...Read More
Tailor-making a protein a-derived domain for efficient site-specific photocoupling to Fc of mouse IgG?.
Affinity proteins binding to antibody constant regions have proved to be invaluable tools in biotechnology. Here, protein engineering was used to expand the repertoire of available immunoglobulin bind...Read More
Streamlining chemical probe discovery: libraries of "fully functionalized" small molecules for phenotypic screening.
Cross-linked: The concept of phenotypic screening with probes of fully functionalized small molecules has recently been introduced. This approach significantly increases the efficiency and success of ...Read More
Copper-catalyzed intramolecular oxidative c?h functionalization and c?n formation of 2-aminobenzophenones: unusual pseudo-1,2-shift of the substituent on the aryl ring.
A good move: A copper-catalyzed intramolecular oxidative C?H functionalization of 2-aminobenzophenone affords two regioisomeric acridones. The reaction involves an unusual pseudo-1,2-migration of R(2)...Read More
Effect of relative humidity on the migration of benzophenone from paperboard into the food simulant Tenax? and modelling hereof.
The aim of this study was to investigate the effect of relative humidity on the migration of benzophenone from paperboard into the food simulant Tenax?. Kinetic migration investigations were carried o...Read More
New insights into the biosynthesis of prenylated xanthones: Xptb from Aspergillus nidulans catalyses an O-prenylation of xanthones.
Gene-inactivation experiments have indicated that the putative prenyltransferase XptB from Aspergillus nidulans was likely to be responsible for the prenylation of 1,7-dihydroxy-6-methyl-8-hydroxymeth...Read More
Detecting the active forms of proteases by using activity-based probes in complex proteomes has become an intensively investigated field of research over the past years because many pathogenic conditi...Read More
Photoreactive, core-shell cross-linked/hollow microspheres prepared by delayed addition of cross-linker in dispersion polymerization for antifouling and immobilization of protein.
When dispersion polymerization of styrene (St) had run for 3h, after particle rapidly growing stage, 4,4'-dimethacryloyloxybenzophenone (DMABP) cross-linker was added to reaction system and photo...Read More
Sigma (σ) receptors are unique non-opioid binding sites that are associated with a broad range of disease states. Sigma-2 receptors provide a promising target for diagnostic imaging and pharmacologic...Read More
Chemicals of emerging concern (CECs) are frequently used in cosmetic formulations and can potentially reach the environment at concentrations that may cause harm. A methodology was developed to assess...Read More
Triplet excited state behavior of naphthalene-based pseudopeptides in the presence of energy donors.
In this work, the triplet state behavior of naphthalene-based pseudopeptides with amide-based macrocyclic or lateral chain substructures has been investigated in the presence of benzophenone and/or bi...Read More
We have synthesized photocrosslinkable benzophenone copolymer, Poly(St-co-MBz), and fabricated cell-repellent patterns of Poly(St-co-MBz) on covalently bound poly-D-lysine (PDL) layer via the photocro...Read More
We have investigated the in vitro inhibition of papain, trypsin, and cathepsins B and G by five benzophenone-type compounds, three natural ones isolated from Garcinia brasiliensis and two synthetic de...Read More
Benzophenone is a phototoxic compound with absorption maxima in the ultraviolet A (UVA) and ultraviolet B (UVB) range. Many benzophenone derivatives are known to be photosensitizing. On the other hand...Read More
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular ol...Read More