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4-氯-L-苯基丙氨酸

产品编号 C100471 | CAS号 14173-39-8 | 阿拉丁
4-Chloro-L-phenylalanine
98%
组合的产品项目
货号 规格 库存 价格 数量
C100471-1g 98% 上海(>10)
北方(预计3-5个工作日)
 
C100471-25g 98% 上海(预计3-7周)
北方(预计3-7周)
 
C100471-5g 98% 上海(5)
北方(预计3-5个工作日)
 
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属性

密度 1.3360
熔点 235-238°C
存贮条件 储存温度-20°C

描述

别名 L-4-氯苯丙氨酸;L-PCPA;L-4-Chlorophenylalanine; H-Phe(4-Cl)-OH; (S)-2-Amino-3-(4-chlorophenyl)propionic acid; L-PCPA; p-Chloro-L-phenylalanine
应用 色氨酸羟化酶(Tryptophan hydroxylase)抑制剂
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标识符号 GHS06 GHS06
信号词 Danger
风险声明 (欧洲) 25,43
安全声明(欧洲) 36/37,45
警示性声明 P280,P301+P310
危害码(欧洲) T
危害声明 H301,H317
个人防护设备 Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges
WGK德国 3
UN代码 2811
参考文献
O O Benkert, M M Bender, F F Bidlingmaier, O O Butenandt
L-p-Chlorophenylalanine (L-PCPA) was given in a dosage of 1.5 g daily, to 6 healthy male subjects over a period of 12 days. No effect on plasma luteinizing hormone (LH), follicle stimulating hormone (...Read More
K Nakadate, K Imamura, Y Watanabe
The roles of the central noradrenergic and serotonergic system in the activity-dependent regulation of ocular dominance plasticity have been a contentious issue. Using c-Fos activity mapping, we have ...Read More
The formation of trigeminal motor nucleus (TMN) was studied in the early postnatal period in 21 female Wistar rats which received the serotonin biosynthesis inhibitor para-chloro-phenylalanine at pren...Read More
Dinesh Dhingra, Ritu Chhillar
The aim of present study was to evaluate antidepressant-like activity of ellagic acid in Swiss young male albino mice; and to explore the possible underlying mechanisms for this activity.Mice were imm...Read More
Daniel F Martins, Leidiane Mazzardo-Martins, Francisco J Cidral-Filho, Juliana Stramosk, Adair R S Santos
Physical therapists frequently use joint mobilization therapy techniques to treat people with musculoskeletal dysfunction and pain. Several studies suggest that endogenous adenosine may act in an anal...Read More
Salina Gairhe, Natalie N Bauer, Sarah A Gebb, Ivan F McMurtry
Myoendothelial gap junctional signaling mediates pulmonary arterial endothelial cell (PAEC)-induced activation of latent TGF-β and differentiation of cocultured pulmonary arterial smooth muscle cells...Read More
Yue Y Tu, Shi-xiang SX Cheng, Hong-tao HT Sun, Tie-zhu TZ Ma, Sai S Zhang
Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a widely distributed natural phenolic compound that is abundant in many plant tissues and foods. This study investigated possible mechanisms unde...Read More
V I VI Mel'nikova, M S MS Izvol'skaia, S N SN Voronova, L A LA Zakharova
In this study, we investigated the influence of serotonin on the development and functioning of T- and B-cell-mediated immunity during ontogenesis using the pharmacological model of serotonin depletio...Read More
Shinichi S Kato, Narumi N Matsuda, Kenjiro K Matsumoto, Mai M Wada, Naoki N Onimaru, Masashi M Yasuda, Kikuko K Amagase, Syunji S Horie, Koji K Takeuchi
Serotonin (5-HT) exerts multiple physiological functions not only in the central and peripheral nervous systems but also in the gastrointestinal tract, and these multiple functions are accounted for b...Read More
Alicia Izquierdo, Kathleen Carlos, Serena Ostrander, Danilo Rodriguez, Aaron McCall-Craddolph, Gargey Yagnik, Feimeng Zhou
Aside from the well-known influence of serotonin (5-hydroxytryptamine, 5-HT) on emotional regulation, more recent investigations have revealed the importance of this monoamine in modulating cognition....Read More
Angela A Chen, Lauren D S LD Kelley, Skirmantas S Janu?onis
The serotonin 5-HT(4) receptor (5-HT(4)R) is coded by a complex gene that produces four mRNA splice variants in mice (5-HT(4(a))R, 5-HT(4(b))R, 5-HT(4(e))R, 5-HT(4(f))R). This receptor has highly dyna...Read More
A V AV Kulikov, D V DV Osipova, V S VS Naumenko, E E Terenina, P P Mormède, N K NK Popova
The neurotransmitter serotonin (5-HT) is involved in the regulation of mouse intermale aggression. Previously, it was shown that intensity of mouse intermale aggression was positively associated with ...Read More
Takuya Hirata, Yoshihiro Keto, Mayumi Yamano, Toshihide Yokoyama, Takanori Sengoku, Nobuo Seki
Symptoms of functional dyspepsia (FD) are highly prevalent in patients with irritable bowel syndrome (IBS). However, the effects of therapeutic agents for IBS on the pathophysiology of FD are unclear....Read More
Shyamshree S S SS Manna, Sudhir N SN Umathe
The present study investigated the influence of transient receptor vanilloid type 1 (TRPV1) channel agonist (capsaicin) and antagonist (capsazepine) either alone or in combination with traditional ant...Read More
Klaus K P?nicke, Ulrich U Gergs, Igor B IB Buchwalow, Steffen S Hauptmann, Joachim J Neumann
Pleiotropic effects of serotonin (5-HT) in the cardiovascular system are well documented. However, it remains to be elucidated, whether 5-HT is present in adult mammalian cardiomyocytes. To address th...Read More
Viviane M VM Linck, Luciane L Costa-Campos, Luísa K LK Pilz, Cícero R L CR Garcia, Elaine E Elisabetsky
The aim of this study was to investigate the involvement of noradrenaline, serotonin, and subtypes of glutamate receptors in the antidepressant-like effects of N-acetylcysteine (NAC). The tail suspens...Read More
Ryan J McLaughlin, Matthew N Hill, Francis R Bambico, Kara L Stuhr, Gabriella Gobbi, Cecilia J Hillard, Boris B Gorzalka
The endocannabinoid system has recently emerged as a vital component of the stress response and is an appealing target for the treatment of mood and anxiety disorders. Additionally, corticolimbic endo...Read More
Ana C AC Stein, Alice F AF Viana, Liz G LG Müller, Jéssica M JM Nunes, Eveline D ED Stolz, Jean-Claude JC Do Rego, Jean J Costentin, Gilsane L GL von Poser, Stela M K SM Rates
In this study we have demonstrated that cyclohexane extract of Hypericum polyanthemum (POL) and its main phloroglucinol derivative uliginosin B (ULI) present antidepressant-like activity in rodent for...Read More
C C Delaville, S S Navailles, A A Benazzouz
Parkinson's disease (PD) is characterized by a degeneration of dopaminergic neurons and also by a degradation of noradrenergic neurons from the locus coeruleus and serotonergic neurons from the d...Read More
Kazuaki K Kawaura, Risa R Miki, Yuri Y Urashima, Ryo R Kawahara, Fumio F Soeda, Tetsuya T Shirasaki, Kazuo K Takahama
We previously reported that the centrally acting non-narcotic antitussive, tipepidine, produces a novel antidepressant-like effect in the forced swimming test in rats, but the mechanism of the antidep...Read More
Mark J MJ Airhart, Deborah H DH Lee, Tracy D TD Wilson, Barney E BE Miller, Merry N MN Miller, Richard G RG Skalko, Paul J PJ Monaco
In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early developmen...Read More
Lee Tran, N Bradley Keele
The amygdala is a key limbic structure strongly implicated in both epilepsy and anxiety disorders. Epilepsy-like mechanisms involve an increased glutamatergic activity, whereas disturbances in seroton...Read More
Kei K Eto, Sun Kwang SK Kim, Junichi J Nabekura, Hitoshi H Ishibashi
Thyrotropin-releasing hormone (TRH) and its analogs have been reported to modulate descending monoaminergic inhibitory neurons, resulting in antinociception. However, it remains unknown whether TRH ex...Read More
Joel Putnam, Georges Guiochon
Acid/base mobile phase modifiers affect enantioseparations in ways that are not fully understood yet, for the lack of systematic studies. This makes chiral analysis of some pharmaceuticals difficult t...Read More
Marta M Kot, W?adys?awa A WA Daniel
The aim of the present study was to ascertain whether the noradrenergic or serotonergic systems may affect the expression of liver cytochrome P450 (CYP). Rats were injected intraperitoneally with N-(2...Read More