|产品介绍||溶解度:14 g/L水 (20°C)、1g/150ml 乙醇 和1g/50ml 苯，，稍溶于醚、氯仿和四氯化碳，溶于丙酮。1：50水溶液对石蕊呈酸性。有氯的气味|
|别名||N-氯代琥珀酰亚胺; N-氯代丁二酰亚胺; 琥珀酰氯亚胺; N-氯丁二酰亚胺; 琥珀酰基氯亚胺; N-氯代二乙酰亚胺; NCS(N-氯代琥珀酰亚胺); 氯代丁二酰亚胺;NCS; Chlorosuccinimide; Succinchlorimide; 1-Chloro-2,5-pyrrolidinedione|
|个人防护设备||Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges|
N-chlorosuccinimide, an efficient reagent for on-resin disulfide formation in solid-phase Peptide synthesis.
N-Chlorosuccinimide is described as a widely applicable on-resin disulfide-forming reagent. Disulfide bond formation was completed within 15 min in DMF. This strategy was successfully used in the synt...Read More
Synthesis of aryl thioethers through the N-chlorosuccinimide-promoted cross-coupling reaction of thiols with Grignard reagents.
A convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were f...Read More
ReactNMR and ReactIR as reaction monitoring and mechanistic elucidation tools: the NCS mediated cascade reaction of α-thioamides to α-thio-β-chloroacrylamides.
On-flow ReactIR and (1)H NMR reaction monitoring, coupled with in situ intermediate characterization, was used to aid in the mechanistic elucidation of the N-chlorosuccinimide mediated transformation ...Read More
One-Electron Reduction ofN-Chlorinated andN-Brominated Species Is a Source of Radicals and Bromine Atom Formation
Hypochlorous (HOCl) and hypobromous (HOBr) acids are strong bactericidal oxidants that are generated by the human immune system but are implicated in the development of many human inflammatory disease...Read More
Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema.
The acceleration of chronic obstructive pulmonary disease (COPD) by cigarette smoke (CS) in individuals with severe genetic deficiency of α(1)-antitrypsin (Z-AT [Glu342Lys]) exemplifies the critical ...Read More
Chloramine-T and N-chlorosuccinimide: novel reagents for diastereoselective oxidation of bisnaphthols.
Two N-chloro reagents (chloramine-T and N-chlorosuccinimide) were used as effective oxidizing agents for the oxidation of bisnaphthols to the corresponding Abel's ketones under mild and convenien...Read More
Application of H-point standard addition method and partial least squares to the simultaneous kinetic-potentiometric determination of hydrazine and phenylhydrazine.
Simultaneous determination of hydrazine (HZ) and phenylhydrazine (PHZ) by H-point standard addition method (HPSAM) and partial least squares (PLS) regression was carried out based on kinetic data from...Read More
Flow injection analysis of riboflavin with chemiluminescence detection using a N-halo compounds-luminol system.
A chemiluminescent method for the determination of riboflavin is described. The method is based on the chemiluminescence (CL) generated during the oxidation of luminol by N-bromosuccinimide (NBS) and ...Read More
Flow injection determination of isoniazid using N-bromosuccinimide- and N-chlorosuccinimide-luminol chemiluminescence systems.
A chemiluminescent method for the determination of isoniazid is described. Method is based on the chemiluminescence (CL) generated during the oxidation of luminol by N-bromosuccinimide (NBS) and N-chl...Read More
Secretory leukoprotease inhibitor augments hepatocyte growth factor production in human lung fibroblasts.
Secretory leukoprotease inhibitor (SLPI), an 11.7-kD nonglycosylated serine protease inhibitor, is produced and released into the fluids of mucosal surfaces including human lung. It comprises two doma...Read More
Structural changes in subfragment 1 of skeletal muscle myosin were investigated by cross-linking trypsin-cleaved S1 with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. In the absence of nucleotide the...Read More
Oxidative difunctionalization of 2-amino-4H-pyrans in iodobenzene diacetate and N-chlorosuccinimide: reactivity, mechanistic insights, and DFT calculations.
Oxidative difunctionalization of 2-amino-4H-pyrans was accomplished with iodobenzene diacetate (IBD) and N-chlorosuccinimide (NCS) reagents in alcoholic medium. 2-Amino-4H-pyrans undergo geminal dialk...Read More
A large number of proteins contain multiple RNA recognition motifs (RRMs). How multiple RRMs contribute to RNA recognition in solution is, however, poorly understood. Here, we describe a simple bioche...Read More
Ferritin is a protein principally known for its role in iron storage. We have previously shown that ferritin can bind high-molecular-weight kininogen (HK). Upon proteolytic cleavage by the protease ka...Read More
Reactivity of Pd(II) complexes with electrophilic chlorinating reagents: isolation of Pd(IV) products and observation of C-Cl bond-forming reductive elimination.
Enantioselective chlorination and fluorination of beta-keto phosphonates catalyzed by chiral Lewis acids.
The direct chiral Lewis acidic enantioselective chlorination and fluorination of beta-keto phosphonates is presented; the chlorination proceeds in high yields and with up to 94% ee using NCS as the ch...Read More
Kininogens are multifunctional proteins involved in a variety of regulatory processes including the kinin-formation cascade, blood coagulation, fibrynolysis, inhibition of cysteine proteinases etc. A ...Read More
The binding site of cyclosporin A to P-glycoprotein was characterized by using a multidrug-resistant Chinese hamster ovary cell line. P-glycoprotein photolabeled with diazirine-cyclosporin A analogue ...Read More