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卡铂

产品编号 C110682 | CAS号 41575-94-4 | Aladdin
Carboplatin
98%
  • 分子式 C6H12N2O4Pt
  • 分子量371.25
  • Beilstein号
  • EC号
  • MDL号 MFCD00070464
  • PubChem编号
组合的产品项目
货号 规格 库存 价格 数量
C110682-100mg 98% 上海(10)
北方(5)
 
C110682-1g 98% 上海(1)
北方(预计3-5个工作日)
 
C110682-5g 98% 上海(1)
北方(预计3-5个工作日)
 
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属性

敏感性 对光敏感
熔点 >275℃

描述

产品介绍 Carboplatin is a second generation potent platinum-based antineoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. Carboplatin displays potent antitumor activity and lower nephrotoxicity than Cisplatin (sc-200896). The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.
别名 卡波铂; 碳铂; 顺-二氨-1,1-环丁烷基二羟酸铂; 顺-二氨-1,1-环丁烷基二羧酸铂; 顺式-1,1-环丁烷二羧酸二氨铂 ;cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II); cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
生化机理 Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.
应用 卡铂是铂为基础的抗癌药物,它会损害DNA,通过形成链内与邻近鸟嘌呤残基偶联。这些药物的抗肿瘤是通过DNA的错配修复丢失(MMR疫苗)的活性和诱导细胞程序性死亡来实现。
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Merck Index 1822