|产品介绍||Reactant for: Suzuki-Miyaura cross coupling Synthesis of nicotinic acetylcholine receptor-selective ligands Enantioselective desymmetrizing palladium catalyzed carbonylation reactions Synthesis of high affinity niacin receptor GPR109A agonists Preparation of heteroaromatics|
|别名||2-[N,N-双(三氟甲基磺酰)氨基]-5-氯吡啶[三氟甲基磺酰化试剂];N,N-双(三氟甲基磺酰)-5-氯-2-吡啶胺; Comins 试剂;2-[双(三氟甲烷磺酰)亚氨基]-5-氯吡啶;2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine;N-(5-Chloro-2-pyridyl)triflimide;Comins Triflating Reagent;|
|个人防护设备||dust mask type N95 (US), Eyeshields, Gloves|
Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.
Antagonist activity at the α3β4 nicotinic acetylcholine receptor (nAChR) is thought to contribute to the antiaddictive properties of several compounds. However, truly selective ligands for the α3β...Read More
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions: the catalytic asymmetric synthesis of quaternary carbon center containing 1,3-dienes.
A desymmetrization protocol has been used to develop a palladium catalyzed enantioselective carbonylation process. Achiral cyclic bis-alkenyltriflates are converted to their corresponding monoester de...Read More
Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A
A series of pyrazolyl propionyl cyclohexenamides were discovered as full agonists for the high affinity niacin receptor GPR109A. The structure-activity relationship (SAR) studies were aimed to improve...Read More