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5-氯-8-羟基-7-碘喹啉

产品编号 C123531 | CAS号 130-26-7 | Aladdin
5-Chloro-8-hydroxy-7-iodoquinoline
>98.0%(T)
组合的产品项目
货号 规格 库存 价格 数量
C123531-10g >98.0%(T) 上海(预计3-7周)
北方(预计3-7周)
 
C123531-50g >98.0%(T) 上海(预计3-7周)
北方(预计3-7周)
 
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属性

熔点 175°C
溶解性 Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).

描述

产品介绍 Clioquinol is a member of the hydroxyquinoline family which inhibits certain enzymes related to DNA replication. Clioquinol is a metal chelating ligand which displays protective effects in various neurodegenerative states as well as being a component in antifungal and antiprotozoal agents. It has been shown to modulate amyloid beta-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12, Clioquinol rescues lead-induced impairments of synaptic plasticity in an animal models. In recent animal studies Clioquinol has shown to reverse the progression of Parkinson's, Alzheimer's, and Huntington's diseases. Clioquinol has been observed to induce apoptosis in human cancer cell lines by generating free zinc in lysosomes.
别名 奎諾仿;氯碘喹啉;氯碘羟喹;5-氯-7-碘-8-羟基喹啉;Clioqinol; 5-Chloro-8-hydroxy-7-iodoquinoline; Iodochlorhydroxyquin;
应用 A metal chelating ligand that inhibits certain enzymes related to DNA replication.
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标识符号 GHS06 GHS06
信号词 Danger
风险声明 (欧洲) R25
安全声明(欧洲) S36/37/39;S45
警示性声明 P301+P310
危害码(欧洲) T
危害声明 H301
个人防护设备 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
WGK德国 3