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二氯乙酸

产品编号 D104244 | CAS号 79-43-6 | 阿拉丁
Dichloroacetic acid
AR,98%
  • 分子式 C2H2Cl2O2
  • 分子量128.94
  • Beilstein号 2,202
  • MDL号 MFCD00004223
组合的产品项目
货号 规格 库存 价格 数量
D104244-100g AR,98% 上海(>10)
北方(预计3-5个工作日)
 
D104244-2.5kg AR,98% 上海(6)
北方(预计3-5个工作日)
 
D104244-25g AR,98% 上海(>10)
北方(预计3-5个工作日)
 
D104244-500g AR,98% 上海(>10)
北方(预计3-5个工作日)
 
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属性

折光率 1.4659
密度 1.5700
熔点 9.7°C
沸点 193-194°C
溶解性 Solubility in water: soluble Solubility in other solvents: miscible with alcohol, ether and ethanol soluble in acetone
存贮条件 密封干燥保存。

描述

产品介绍 Dichloroacetic acid is a simple halogenated acetic acid compound with two chlorides at the α-position. Dichloroacetic acid has been demonstrated to inhibit mitochondrial PDK (pyruvate dehydrogenase kinase) and to shift cellular metabolism from glycolysis to glucose oxidation, and these activities have been correlated to interruption of apoptosis resistance in certain cancer cell lines.
别名 二氯醋酸;Acetic acid;Urner's liquid
应用 A mitochondrial PDK (pyruvate dehydrogenase kinase) inhibitor.
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标识符号 GHS05 GHS05, GHS09 GHS09
信号词 Danger
风险声明 (欧洲) R35;R50
安全声明(欧洲) S26;S45;S61
警示性声明 P273,P280,P305+P351+P338,P310
危害码(欧洲) C,N
危害声明 H314,H400
个人防护设备 Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
WGK德国 2
Merck Index 3050
闪点(摄氏) >112℃
是否危化品 一般危险品
UN代码 1764
参考文献
R Scott RS Obach, Franco F Lombardo, Nigel J NJ Waters
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...Read More
Simon Hu, Hikari A I Yoshihara, Robert Bok, Jenny Zhou, Minhua Zhu, John Kurhanewicz, Daniel B Vigneron
Development of hyperpolarized technology utilizing dynamic nuclear polarization has enabled the measurement of (13)C metabolism in vivo at very high signal-to-noise ratio (SNR). In vivo mitochondrial ...Read More
Alfonso Pérez-Garrido, Maykel Pérez González, Amalio Garrido Escudero
We're sorry this abstract is currently not available....Read More
Gerald Pfeffer, Kari Majamaa, Douglass M Turnbull, David Thorburn, Patrick F Chinnery
Mitochondrial respiratory chain disorders are the most prevalent group of inherited neurometabolic diseases. They present with central and peripheral neurological features usually in association with ...Read More
Masashi Saito, Kazuhito Yano, Takashi Kamigaki, Shigenori Goto
A 35-year-old female with scirrhous stomach cancer (stage IV) was treated with a combination of 5-aminolevulinic acid (ALA), sodium dichloroacetate (DCA), hyperthermotherapy, and immunotherapy as term...Read More
Michael S Dodd, Vicky Ball, Rosalind Bray, Houman Ashrafian, Hugh Watkins, Kieran Clarke, Damian J Tyler
Alterations in cardiac metabolism accompany many diseases of the heart. The advent of cardiac hyperpolarized magnetic resonance spectroscopy (MRS), via dynamic nuclear polarization (DNP), has enabled ...Read More
Shun Tang, Xiao-Mao Wang, Hong-Wei Yang, Yuefeng F Xie
An innovative haloacetic acid (HAA) removal process was developed. The process consisted of a zero-valent iron (Fe(0)) column followed by a biologically active carbon (BAC) column that were efficient ...Read More
Jae Mo Park, Lawrence D Recht, Sonal Josan, Milton Merchant, Taichang Jang, Yi-Fen Yen, Ralph E Hurd, Daniel M Spielman, Dirk Mayer
Background The metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using hyperpolarized [...Read More
Yi-Hsueh Chuang, Angela Yu-Chen Lin, Xiao-Huan Wang, Hsin-Hsin Tung
The direct incorporation of chloramines and dissolved organic nitrogen (DON) may provide the nitrogen for nitrogenous disinfection byproducts (N-DBPs). This study explores the contributions of natural...Read More
Petra Weber, Michael Wagner, Petra Kioschis, Waltraud Kessler, Herbert Schneckenburger
Autofluorescence spectra, images, and decay kinetics of U251-MG glioblastoma cells prior and subsequent to activation of tumor suppressor genes are compared. While phase contrast images and fluorescen...Read More
Joanne E Mallinson, Dumitru Constantin-Teodosiu, Philip D Glaves, Elizabeth A Martin, Wendy J Davies, F Russell Westwood, James E Sidaway, Paul L Greenhaff
Abstract? We previously reported that statin myopathy is associated with impaired carbohydrate (CHO) oxidation in fast-twitch rodent skeletal muscle, which we hypothesised occurred as a result of fork...Read More
Benedikt Feuerecker, Sabine Pirsig, Christof Seidl, Michaela Aichler, Annette Feuchtinger, Gernot Bruchelt, Reingard Senekowitsch-Schmidtke
Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis-Warburg effect). New concepts in cancer treatment aim at inhibition of aerobic glycolysis. Pyr...Read More
Bassem F El-Khodor, Kim Cirillo, Jose A Beltran, Richard Mushlin, Margaret L Winberg, Rachel Charney, Olga Chomicova, Tara Marino, Sylvie Ramboz
Proximal Spinal Muscular Atrophy (SMA) is a debilitating neuromuscular disease and a leading inherited genetic cause of infant death. To date, there is no effective treatment for SMA. The SMNΔ7 neona...Read More
Ajay A Kumar, Shiva S Kant, Sukh Mahendra SM Singh
Pyruvate dehydrogenase kinase (PDK) inhibits pyruvate dehydrogenase (PDH) activity and thus promotes energetic switch from mitochondrial glucose oxidation to cytoplasmic glycolysis in cancerous cells ...Read More
Tatsuaki T Ishiguro, Ryumei R Ishiguro, Miyu M Ishiguro, Sayuri S Iwai
Omeprazole (OPZ) and tamoxifen (TAM) strengthen the effects of anticancer drugs and dichloroacetate (DCA) inhibits tumor growth. This study assesses the synergistic effects of these drugs....Read More
Mohammad M Mehrjouei, Siegfried S Müller, Detlev D M?ller
The performance of a heterogeneous photocatalytic ozonation system (TiO(2)/UVA/O(3)) was evaluated on the degradation and mineralization of dichloroacetic acid as a contaminant in aqueous solutions by...Read More
Jovonia T JT Washington, Nicholas J NJ Quintyne
The pyruvate mimetic dichloroacetate (DCA) has been shown to induce cell death in cancer cells. A number of studies in vitro and in vivo have suggested this molecule may serve as an anticancer agent, ...Read More
S Fujiwara, Y Kawano, H Yuki, Y Okuno, K Nosaka, H Mitsuya, H Hata
Background:Cancer cells utilise the glycolytic pathway even when adequate oxygen is present, a phenomenon known as the Warburg effect. We examined whether this system is operative in multiple myeloma ...Read More
Friedrich C Luft
We're sorry this abstract is currently not available....Read More
Lin Piao, Vaninder K Sidhu, Yong-Hu Fang, John J Ryan, Kishan S Parikh, Zhigang Hong, Peter T Toth, Erik Morrow, Shelby Kutty, Gary D Lopaschuk, Stephen L Archer
Pyruvate dehydrogenase kinase (PDK) is activated in right ventricular hypertrophy (RVH), causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. The st...Read More
Haihua H Xiao, Lesan L Yan, Yu Y Zhang, Ruogu R Qi, Wenliang W Li, Rui R Wang, Shi S Liu, Yubin Y Huang, Yuxin Y Li, Xiabin X Jing
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to ...Read More
Kasirajan Ayyanathan, Shailaja Kesaraju, Ken Dawson-Scully, Herbert Weissbach
Sulindac is an FDA-approved non-steroidal anti-inflammatory drug with documented anticancer activities. Our recent studies showed that sulindac selectively enhanced the killing of cancer cells exposed...Read More
Jérome J Kluza, Paola P Corazao-Rozas, Yasmine Y Touil, Manel M Jendoubi, Cyril C Maire, Pierre P Guerreschi, Aurélie A Jonneaux, Caroline C Ballot, Stéphane S Balayssac, Samuel S Valable, Aurélien A Corroyer-Dulmont, Myriam M Bernaudin, Myriam M Malet-Ma
Cancer cells can undergo a metabolic reprogramming from oxidative phosphorylation to glycolysis that allows them to adapt to nutrient-poor microenvironments, thereby imposing a selection for aggressiv...Read More
Marie M Morfouace, Lisenn L Lalier, Muriel M Bahut, Virginie V Bonnamain, Philippe P Naveilhan, Catherine C Guette, Lisa L Oliver, Naig N Gueguen, Pascal P Reynier, Francois M FM Vallette
Cancer stem cells (CSCs) are thought to be partially responsible for cancer resistance to current therapies and tumor recurrence. Dichloroacetate (DCA), a compound capable of shifting metabolism from ...Read More
Mehdi D Esrafili
A theoretical study was performed to examine hydrogen and halogen bonds properties in gas phase and crystalline dichloroacetic acid (DCAA). The specific pattern of O-H???O, C-H???O, HCl, Cl???O and Cl...Read More
J J Pokorny, A A Jandová, M M Nedbalová, F F Jelínek, M M Cifra, O O Ku?era, D D Havelka, J J Vrba, J J Vrba, A A Co?ek, J J Kobilková
Physical processes in living cells were not taken into consideration among the essentials of biological activity, regardless of the fact that they establish a state far from th...Read More
Ernesto Miquel, Adriana Cassina, Laura Martínez-Palma, Carmen Bolatto, Emiliano Trías, Mandi Gandelman, Rafael Radi, Luis Barbeito, Patricia Cassina
Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1(G93A) mutation display a ...Read More
Marena Rebekka MR Niewisch, Zyrafete Z Ku?i, Hartwig H Wolburg, Mirjam M Sautter, Lea L Krampen, Beate B Deubzer, Rupert R Handgretinger, Gernot G Bruchelt
Many cancer cells metabolize glucose preferentially via pyruvate to lactate instead to CO(2) and H(2)O (oxidative phosphorylation) even in the presence of oxygen (Warburg effect). Dichloroacetate (DCA...Read More

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