|标识符号||GHS06, GHS08, GHS09|
|个人防护设备||Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges|
The objective of the present study was to evaluate the physicochemical and biochemical profiling of diphenyl diselenide (PhSe)(2), a selenoorganic compound with biological activity. Experimental proto...Read More
Diphenyl diselenide has shown interesting biological activities in various free-radical-induced damage models and can be considered as a potential candidate drug against oxidative stress. Apart from i...Read More
This study investigated the effects of co-administration of diphenyl diselenide [(PhSe)(2)] and 17β-estradiol (E(2)) on spatial reference, recognition, and working memories in ovariectomized (OVX) fe...Read More
In vitro metabolism of diphenyl diselenide in rat liver fractions. Conjugation with GSH and binding to thiol groups.
In spite of an extensive literature reporting pharmacological properties of diphenyl diselenide, (PhSe)(2), little is known about its metabolism. The aim of this study was to identify possible metabol...Read More
Antioxidant properties of diorganoyl diselenides and ditellurides: modulation by organic aryl or naphthyl moiety.
Diorganoyl dichalcogenide compouds can have antioxidant activity in different in vitro and in vivo models. Here, we have compared the potential antioxidant activity of 1-dinaphthyl diselenide (1-NapSe...Read More
Reaction of glycal derivatives with alcohols in the presence of N-bromosuccinimide and diphenyldiselenide: preparation of 2-deoxy-2-phenylselenyl glycosides.
Reaction of glycal derivatives with alcohols or glycosyl acceptors in the presence of N-bromosuccinimide (NBS) and diphenyldiselenide resulted in the formation of alkyl 2-deoxy-2-phenylselenyl glycosi...Read More
Effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)2 on toxicity induced by mercuric chloride in mice: a comparative study with diphenyl diselenide (PhSe)2.
The effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)(2) on the toxicity induced by mercuric chloride (HgCl(2)) were investigated and compared with diphenyl diselenide (PhSe)(2). Mice receive...Read More
Protective effect of diphenyl diselenide on ischemia and reperfusion-induced cerebral injury: involvement of oxidative stress and pro-inflammatory cytokines.
Cerebrovascular diseases, including ischemic stroke, are associated with high mortality worldwide. Oxidative stress and inflammation are important pathophysiological mechanisms involved in post-ischem...Read More
Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels.
We reported the anti-inflammatory action of diphenyl diselenide [(PhSe)(2)] in an acute inflammation model induced by carrageenan.Male adult Swiss mice.Mice were treated with (PhSe)(2) (50?mg/kg) or v...Read More
Comparative excretion and tissue distribution of selenium in mice and rats following treatment with diphenyl diselenide.
The purpose of this study was to provide data about in vivo tissue distribution and excretion of diphenyl diselenide ((PhSe)(2)) in rats and mice through determination of selenium levels in different ...Read More
Cooperation of non-effective concentration of glutamatergic system modulators and antioxidant against oxidative stress induced by quinolinic acid.
Excessive formation of reactive oxygen species (ROS) and disruption of glutamate uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-induced toxicity. Thus, here we in...Read More
The effects of diphenyl diselenide on oxidative stress biomarkers in Cyprinus carpio exposed to herbicide quinclorac (Facet?).
The occurrence of pollutants in the aquatic environment can produce severe toxic effects on non-target organisms, including fish. These sources of contamination are numerous and include herbicides, wh...Read More
Diphenyl diselenide attenuates hepatic and hematologic toxicity induced by chlorpyrifos acute exposure in rats.
In this study, we investigated the effect of diphenyl diselenide [(PhSe)(2)] on chlorpyrifos (CPF)-induced hepatic and hematologic toxicity in rats....Read More
Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain.
Bipolar disorder (BD) is a common and severe mood disorder associated with higher rates of suicide and disability. Ouabain, a Na(+)/K(+)-ATPase inhibitor, induces behavioral changes in rats and has be...Read More
Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system.
The transition to menopause is associated with an increased risk of depressed mood.This study was conducted to investigate whether diphenyl diselenide [(PhSe)?] treatment could reduce the effects of p...Read More
Reduction of acute hepatic damage induced by acetaminophen after treatment with diphenyl diselenide in mice.
In this study, the authors evaluated the ability of diphenyl diselenide (PhSe)(2) to reverse acute hepatic failure induced by acetaminophen (APAP) in mice. The animals received an APAP dose of 600 mg/...Read More
This study evaluated the in vitro activity of diphenyl diselenide against 19 Pythium insidiosum isolates and the in vivo therapeutic response of rabbits with experimentally induced pythiosis. In vitro...Read More
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated inflammatory and demyelinating disease of the central nervous system with clinical and pathological similarities with multiple scle...Read More
Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions.
We evaluated the potential neuroprotective effect of 1-100 μM of four organoselenium compounds: diphenyl diselenide, 3'3-ditri-fluoromethyldiphenyl diselenide, p-methoxy-diphenyl diselenide, and...Read More
Diphenyl diselenide diet intake improves spatial learning and memory deficits in hypothyroid female rats.
Cognitive deficits have been observed in different animal models of adult-onset hypothyroidism. Thus, this study was delineated to evaluate whether diphenyl diselenide, an organoselenium compound with...Read More
Methylselenocysteine treatment leads to diselenide formation in human cancer cells: evidence from X-ray absorption spectroscopy studies.
The selenoamino acids methylselenocysteine (MeSeCys) and selenomethionine (SeMet) have disparate efficacies as anticancer agents. Herein, we use X-ray absorption spectroscopy to determine the chemical...Read More
Diphenyl diselenide-modulation of macrophage activation: down-regulation of classical and alternative activation markers.
Diphenyl diselenide (PhSe)(2), a simple organoselenium compound, possesses interesting pharmacological properties that are under extensive research. As macrophages respond to microenvironmental stimul...Read More
Ovarian hormone loss contributes to cognitive decline in postmenopausal women. Studies have demonstrated a positive role of the level of the element selenium in cognitive performance. The present stud...Read More
The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains.
This study was designed to investigate the protective effects of the combination of guanosine and 2 organoselenium compounds (ebselen and diphenyl diselenide) against glutamate-induced oxidative stres...Read More
Acute brain damage induced by acetaminophen in mice: effect of diphenyl diselenide on oxidative stress and mitochondrial dysfunction.
Organoselenium compounds exhibit antioxidant activity, as well as a variety of biological activities, with potential pharmacological and therapeutic applications. The aim of this study was to investig...Read More