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Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.
The medical and social impact of cough is substantial. Current antitussive agents at effective doses...Read More
Efficacy and safety of levodropropizine and dihydrocodeine on nonproductive cough in primary and metastatic lung cancer.
Nonproductive cough is a frequent and distressing symptom in patients with lung cancer, and it is no...Read More
Efficacy and Tolerability of Levodropropizine in Adult Patients with Non-productive Cough. Comparison with Dextromethorphan
The results of a double-blind, randomized clinical trial involving 209 adult patients of either sex ...Read More
High-performance liquid chromatographic determination of levodropropizine in human plasma with fluorometric detection.
The present paper describes a new high-performance liquid chromatographic method with fluorescence d...Read More
1. Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single-unit discharge of...Read More
Virus-induced airway inflammation and hyperresponsiveness in the guinea-pig is inhibited by levodropropizine.
Intratracheal Parainfluenza type 3 (PI-3) virus inoculation of guinea pigs leads to a non-specific a...Read More
Enantioselective effects of levodropropizine and dropropizine on psychomotor functions in normal volunteers: a placebo-controlled, double-blind comparative study.
Levodropropizine is the l-isomer of dropropizine, a racemic drug widely used as a cough suppressant....Read More
The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF ...Read More
Effectiveness of levodropropizine against cigarette smoke-induced airway hyperreactivity: possible mechanism.
We verified the possible effect of the new antitussive drug levodropropizine on airway hyperreactivi...Read More
Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.
The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine wer...Read More
Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.
We investigated the effect of the non-opioid, peripherally acting antitussive agent levodropropizine...Read More
Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Korean volunteers: a singledose, randomized-sequence, open-label, two-way crossover study.
Background: Levodropropizine is an oral non-opioid anti-tussive drug used in treatment of cough. A n...Read More
Cough in children is among the most common problems managed by pediatricians, and occurs more freque...Read More
Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review.
Cough associated with cancer or nonmalignant chronic disease is common and distressing. Levodropropi...Read More
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The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
The ATP-sensitive potassium ion channels (K+ATP) are widely expressed on airway sensory nerves that ...Read More
HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.
A simple HPLC method using UV detection was developed and validated for the determination of levodro...Read More
Peripheral site of action of levodropropizine in experimentally-induced cough: role of sensory neuropeptides.
The mechanism of action of levodropropizine has been investigated in different models of experimenta...Read More
To develop a rapid and sensitive LC/MS/MS method for the analysis of levodropropizine in plasma and ...Read More
Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma.
A rapid and sensitive LC-MS-MS method for quantifying levodropropizine in human plasma after oral ad...Read More
Cough is the most important defence reflex of the airways. Little information exists about participa...Read More
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.
Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppress...Read More
Levodropropizine, an antitussive drug, was prepared in high enantiomeric excess in three steps, star...Read More
Levodropropizine does not affect P0.1 and breathing pattern in healthy volunteers and patients with chronic respiratory impairment.
To evaluate whether the peripherally acting antitussive levodropropizine could affect the respirator...Read More