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羟丙哌嗪

产品编号 D118870 | CAS号 17692-31-8 | 阿拉丁
(±)-Dropropizine
97%
组合的产品项目
货号 规格 库存 价格 数量
D118870-25g 97% 上海(>10)
北方(预计3-5个工作日)
 
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描述

别名 ;3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R22
安全声明(欧洲) S36
危害码(欧洲) Xn
危害声明 H302
个人防护设备 dust mask type N95 (US), Eyeshields, Gloves
WGK德国 3
参考文献
P P Aliprandi, C C Castelli, S S Bernorio, E E Dell'Abate, M M Carrara
The medical and social impact of cough is substantial. Current antitussive agents at effective doses have adverse events such as drowsiness, nausea and constipation that limit their use. There is also...Read More
G Luporini, S Barni, E Marchi, L Daffonchio
Nonproductive cough is a frequent and distressing symptom in patients with lung cancer, and it is not even relieved by palliative chemotherapy. A double-blind, randomized clinical trial regarding the ...Read More
E E Catena, L L Daffonchio
The results of a double-blind, randomized clinical trial involving 209 adult patients of either sex with moderate non-productive cough are reported. The therapeutic efficacy and the tolerability of le...Read More
F Tagliaro, M Moffa, Z De Battisti, F P Smith, M Gentile
The present paper describes a new high-performance liquid chromatographic method with fluorescence detection for the analysis of levodropropizine [S-(-)-3-(4-phenylpiperazin-1-yl)-propane-1,2-diol] (L...Read More
H H Shams, L L Daffonchio, P P Scheid
1. Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single-unit discharge of vagal afferent C-fibres were tested in anaesthetized cats to assess whether an inhibition of vagal ...Read More
G G Folkerts, H J HJ van der Linde, C C Omini, F P FP Nijkamp
Intratracheal Parainfluenza type 3 (PI-3) virus inoculation of guinea pigs leads to a non-specific airway hyperresponsiveness in vivo and in vitro which coincides with a significant increase in the nu...Read More
G G Gatti, N N Barzaghi, R R Dominijanni, C C Cordaro, E E Perucca
Levodropropizine is the l-isomer of dropropizine, a racemic drug widely used as a cough suppressant. Compared with the racemate, levodropropizine retains equal antitussive activity but exhibits consid...Read More
P L PL Munt, G G Clavenna, D R DR Algate, R M RM Leach
The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine ...Read More
L L Daffonchio, A A Hernandez, G G Melillo, G G Clavenna, C C Omini
We verified the possible effect of the new antitussive drug levodropropizine on airway hyperreactivity and lung inflammation induced by cigarette smoke exposure in anaesthetized guinea-pigs. Levodropr...Read More
G G Banderali, E E Riva, A A Fiocchi, C I CI Cordaro, M M Giovannini
The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for e...Read More
I I Yamawaki, P P Geppetti, C C Bertrand, O O Huber, L L Daffonchio, C C Omini, J A JA Nadel
We investigated the effect of the non-opioid, peripherally acting antitussive agent levodropropizine to reduce neurogenic plasma extravasation in the rat trachea. Levodropropizine (10, 50 and 200 mg/k...Read More
Jae-Won Jang, Ji-Hyung Seo, Min-Ho Jo, Young-Joo Lee, Young-Wuk Cho, Sung-Vin Yim, Kyung-Tae Lee
Background: Levodropropizine is an oral non-opioid anti-tussive drug used in treatment of cough. A new generic 60 mg capsule formulation of levodropropizine has recently been developed. Objectives: Th...Read More
Francesco De Blasio, Peter V Dicpinigaitis, Gianluca De Danieli, Luigi Lanata, Alessando Zanasi
Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respir...Read More
Eva Katharina EK Schildmann, Constanze C Rémi, Claudia C Bausewein
Cough associated with cancer or nonmalignant chronic disease is common and distressing. Levodropropizine, a peripherally acting drug, has been used as an alternative antitussive to opioids. The author...Read More
G-Y GY Hur, S-Y SY Lee, J-J JJ Shim, H-S HS Park, K-H KH Kang
We're sorry this abstract is currently not available....Read More
M M Sutovska, S S Franova, J J Sutovsky
The ATP-sensitive potassium ion channels (K+ATP) are widely expressed on airway sensory nerves that mediate cough and other protective reflexes; dependent on airways smooth muscles (ASM) reactivity....Read More
Lin Yan, Tongling Li, Rongqin Zhang, Xiaohong Xu, Pengcheng Zheng
A simple HPLC method using UV detection was developed and validated for the determination of levodropropizine (LDP) in dog plasma. The sample was prepared for injection using a liquid-liquid extractio...Read More
A A Lavezzo, G G Melillo, G G Clavenna, C C Omini
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug h...Read More
Li-mei LM Zhao, Li L Zhao, Ya-xin YX Sun, Feng F Qiu, Shan-bin SB Guo
To develop a rapid and sensitive LC/MS/MS method for the analysis of levodropropizine in plasma and study the pharmacokinetics of levodropropizine in healthy Chinese volunteers....Read More
Yunbiao Y Tang, Limei L Zhao, Yingwu Y Wang, J Paul JP Fawcett, Jingkai J Gu
A rapid and sensitive LC-MS-MS method for quantifying levodropropizine in human plasma after oral administration of a single-dose (60 mg/day) was developed and validated. The sample preparation used l...Read More
S S Franova, G G Nosalova
Cough is the most important defence reflex of the airways. Little information exists about participation of the ion channels in the mechanism of the cough reflex....Read More
Roland F Staack, Denis S Theobald, Hans H Maurer
Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chroma...Read More
Emilia Caselli, Giovanni Tosi, Arrigo Forni, Maria Bucciarelli, Fabio Prati
Levodropropizine, an antitussive drug, was prepared in high enantiomeric excess in three steps, starting from dichloroacetone (2). Monosubstitution of 2 with sodium benzoate and subsequent baker'...Read More
C Bruschi, P Crotti, E Dacosto, F Fanfulla, L Daffonchio, R Novellini
To evaluate whether the peripherally acting antitussive levodropropizine could affect the respiratory drive and the breathing pattern, we performed a double-blind, randomised, cross-over trial in 12 h...Read More

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