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羟基脲

¥ 45.00

产品编号 H106352 | CAS号 127-07-1 | Aladdin
Hydroxyurea
98%
组合的产品项目
货号 规格 库存 价格 数量
H106352-1g 98% 上海(6)
北方(预计3-5个工作日)
 
H106352-25g 98% 上海(预计3-7周)
北方(预计3-7周)
 
H106352-5g 98% 上海(3)
北方(预计3-5个工作日)
 
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属性

密度 1.4570
熔点 145°C
存贮条件 储存温度2-8°C

描述

产品介绍 易溶于水和热乙醇,微溶于冷乙醇,不溶于乙醚;苯。遇水或热不稳定。无臭,无味。
别名 羟基脲 ;羟基尿素,氨基甲酰基羟胺,氨甲酰羟基胺;Hydroxycarbamide Carbamoylhydroxylamine
应用 靠形成游离的一氧化氮,结合到酶活性部位的酪氨酸而使核苷还原酶失活。
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标识符号 GHS08 GHS08
信号词 Warning
风险声明 (欧洲) R46;R61;
安全声明(欧洲) S45;S53;
警示性声明 P281
危害码(欧洲) T
危害声明 H361
个人防护设备 Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS YT4900000
WGK德国 3
Merck Index 4848
UN代码 2811
参考文献
R Scott RS Obach, Franco F Lombardo, Nigel J NJ Waters
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...Read More
Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan
Kidney plays an important role in the elimination of drugs, especially with low or negligible hepatic clearance. An analysis of the interrelation of physicochemical properties and the human renal clea...Read More
Manthena V S MV Varma, R Scott RS Obach, Charles C Rotter, Howard R HR Miller, George G Chang, Stefanus J SJ Steyn, Ayman A El-Kattan, Matthew D MD Troutman
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database comprised ...Read More
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Francisco J Prado-Prado, Xerardo García-Mera, Humberto González-Díaz
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one pa...Read More
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers, Peter B Dirks
We're sorry this abstract is currently not available....Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
Dennis J Pelletier, Daniel Gehlhaar, Anne Tilloy-Ellul, Theodore O Johnson, Nigel Greene
The identification of phospholipidosis (PPL) during preclinical testing in animals is a recognized problem in the pharmaceutical industry. Depending on the intended indication and dosing regimen, PPL ...Read More
Minjun M Chen, Vikrant V Vijay, Qiang Q Shi, Zhichao Z Liu, Hong H Fang, Weida W Tong
Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effec...Read More
Miriam Schonbrun, Dana Laor, Luis López-Maury, Jürg B?hler, Martin Kupiec, Ronit Weisman
The Target Of Rapamycin (TOR) kinase belongs to the highly conserved eukaryotic family of phosphatidylinositol-3-kinase-related kinases (PIKKs). TOR proteins are found at the core of two distinct evol...Read More
I L Zungu, A B Mbene, D H Hawkins Evans, N N Houreld, H Abrahamse
Phototherapy has been shown to cause an increase in cell proliferation and migration. This study focused on viability (trypan blue), proliferation [sodium 3'-(1-(phenylaminocarbonyl)-3,4-tetrazol...Read More
Nicholas Willis, Nicholas Rhind
The S-phase DNA damage checkpoint slows the rate of DNA synthesis in response to damage during replication. In the fission yeast Schizosaccharomyces pombe, Cds1, the S-phase-specific checkpoint effect...Read More
Nicholas Willis, Nicholas Rhind
The Mre11-Rad50-Nbs1 (MRN) heterotrimer plays various and complex roles in DNA damage repair and checkpoint signaling. Its role in activating Ataxia-Telangiectasia Mutated (ATM), the central checkpoin...Read More
Sung-Hwan Moon, Lin Lin, Xinna Zhang, Thuy-Ai Nguyen, Yolanda Darlington, Alan S Waldman, Xiongbin Lu, Lawrence A Donehower
In response to DNA double strand breaks, the histone variant H2AX at the break site is phosphorylated at serine 139 by DNA damage sensor kinases such as ATM (ataxia telangiectasia mutated), forming ga...Read More
Matthew P Torres, Sarah T Clement, Steven D Cappell, Henrik G Dohlman
A diverse array of external stimuli, including most hormones and neurotransmitters, bind to cell surface receptors that activate G proteins. Mating pheromones in yeast Saccharomyces cerevisiae activat...Read More
Brendon J Monahan, Judit Villén, Samuel Marguerat, Jürg B?hler, Steven P Gygi, Fred Winston
We're sorry this abstract is currently not available....Read More
Jin Sun, Hiroshi Okumura, Martha Yearsley, Wendy Frankel, Louise Y Fong, Teresa Druck, Kay Huebner
The fragile histidine triad gene (human FHIT, mouse Fhit) has been shown to act as a tumor suppressor gene. Nit1 and Fhit form a fusion protein, encoded by the NitFhit gene in flies and worms, suggest...Read More
V Olive, M J Bennett, J C Walker, C Ma, I Jiang, C Cordon-Cardo, Q-J Li, S W Lowe, G J Hannon, L He
Recent studies have revealed the importance of multiple microRNAs (miRNAs) in promoting tumorigenesis, among which mir-17-92/Oncomir-1 exhibits potent oncogenic activity. Genomic amplification and ele...Read More
Kim Engels, Michele Giannattasio, Marco Muzi-Falconi, Massimo Lopes, Stefano Ferrari
Replication fork integrity, which is essential for the maintenance of genome stability, is monitored by checkpoint-mediated phosphorylation events. 14-3-3 proteins are able to bind phosphorylated prot...Read More
Tahir Shamsi, Saqib Ansari
We're sorry this abstract is currently not available....Read More
Nabil Matmati, Alessandra Metelli, Kaushlendra Tripathi, Shuqi Yan, Bidyut K Mohanty, Yusuf A Hannun
Recent studies showed that deletion of ISC1, the yeast homologue of the mammalian neutral sphingomyelinase, resulted in an increased sensitivity to hydroxyurea (HU). This raised an intriguing question...Read More
Roberto Marchioli, Alessandro Maria Vannucchi, Tiziano Barbui
To the Editor: In their report on the Cytoreductive Therapy in Polycythemia Vera (CYTO-PV) study, Marchioli et al. (Jan. 3 issue)(1) provide prospective evidence confirming the appropriate hematocrit ...Read More
Mary Frances McMullin, Claire N Harrison, Jean Jacques Kiladjian
To the Editor: In their report on the Cytoreductive Therapy in Polycythemia Vera (CYTO-PV) study, Marchioli et al. (Jan. 3 issue)(1) provide prospective evidence confirming the appropriate hematocrit ...Read More
Nathalie Lemonne, Yann Lamarre, Marc Romana, Martin Mukisi-Mukaza, Marie-Dominique Hardy-Dessources, Vanessa Tarer, Danielle Mougenel, Xavier Waltz, Beno?t Tressières, Marie-Laure Lalanne-Mistrih, Maryse Etienne-Julan, Philippe Connes
We're sorry this abstract is currently not available....Read More
Marco Ruella, Silvia Salmoiraghi, Alessandra Risso, Alessandra Carobbio, Stefano Buttiglieri, Tiziana Spatola, Piera Sivera, Irene Ricca, Tiziano Barbui, Corrado Tarella, Alessandro Rambaldi
The purpose of this study was to investigate telomere length (TL) in Ph-negative chronic myeloproliferative neoplasms (Ph-neg-CMNs), and the possible association of TL with disease progression and hyd...Read More
Veronika Anyigoh Atemnkeng, Mario Pink, Simone Schmitz-Spanke, Xian-Jun Wu, Liang-Liang Dong, Kai-Hong Zhao, Caroline May, Stefan Laufer, Barbara Langer, Annette Kaiser
Primaquine, an 8-aminoquinoline, is the only drug which cures the dormant hypnozoites of persistent liver stages from P. vivax. Increasing resistance needs the discovery of alternative pathways as dru...Read More
Sharef Waadallah Sharef, Maya Al-Hajri, Ismail Beshlawi, Aamir Al-Shahrabally, Mohamed Elshinawy, Mathew Zachariah, Surekha Tony Mevada, Wafaa Bashir, Abdulhakim Rawas, Aqeela Taqi, Zakiya Al-Lamki, Yasser Wali
Hydroxyurea (HU) is the standard treatment for severely affected children with sickle cell disease (SCD). Starting dose is 15-20 mg/kg/day that can be escalated up to 35 mg/kg/day. Ethnic neutropenia ...Read More
Benjamin Hensley, Holly Geyer, Ruben Mesa
INTRODUCTION: In the past, management of polycythemia vera (PV) was built upon a cornerstone of control over erythrocytosis, through therapeutic phlebotomy, as well as the use of low-dose aspirin. His...Read More
Suchitra Natarajan, Sabine Hombach-Klonisch, Peter Dr?ge, Thomas Klonisch
The non-histone chromatin binding protein high mobility group AT-hook 2 (HMGA2) is expressed in stem cells and many cancer cells, including tumor initiating cells, but not translated in normal human s...Read More
Barbara J Bain, Catherine Garnett, Simona Deplano, Kikkeri Naresh, Ed Kanfer
We're sorry this abstract is currently not available....Read More
Toru Nakayashiki, Natsumi Saito, Rikiya Takeuchi, Hiroshi Kadokura, Kenji Nakahigashi, Barry L Wanner, Hirotada Mori
We have performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli K-12. HU inhibits ribonucleotide reductase (RNR), an enzyme that ...Read More
Linyu Deng, Jing Zhang, Taixiang Wu, Theresa A Lawrie
This is an update of the original review that was published in The Cochrane Database of Systematic Reviews, 2009, Issue 2. Gestational trophoblastic neoplasia (GTN) are malignant disorders of the plac...Read More
M S Mahbub, L Khondker, S I Khan, S C Hazra
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Jane J Lew, Steven J SJ Frucht, Marina M Kremyanskaya, Ronald R Hoffman, John J Mascarenhas
We're sorry this abstract is currently not available....Read More
Clarisse Lopes de Castro Lobo, Jorge F C Pinto, Emilia M Nascimento, Patricia G Moura, Gilberto P Cardoso, Jane S Hankins
Although evidence is accumulating that hydroxycarbamide decreases mortality among adults with sickle cell disease (SCD), there are no published data regarding the effect of hydroxycarbamide on mortali...Read More
Guido Finazzi, Alessandro M Vannucchi, Vincenzo Martinelli, Marco Ruggeri, Francesco Nobile, Giorgina Specchia, Enrico Maria Pogliani, Odoardo Maria Olimpieri, Giuseppe Fioritoni, Caterina Musolino, Daniela Cilloni, Piera Sivera, Giovanni Barosi, Maria Ch
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It is unclear how DNA-damaging agents target cancer cells over normal somatic cells.Arf/p53-dependent down-regulation of H2AX enables normal cells to survive after DNA damage.Transformed cells, which ...Read More
Wenjian Chen, Chengtan Li, Jianbo Zhao, Xiaoyan Zhang, Huayang Han, Erqing Wei, Lihui Zhang
To determine 5-lipoxygenase (5-LOX) expression and the effect of zileuton, a selective 5-LOX inhibitor,on hippocampal neuron injury induced by global cerebral ischemia in rats.Global cerebral ischemia...Read More
Hugh Ip, Rachel Kesse-Adu, Jo Howard, Nicholas Hart
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Jeffrey D Lebensburger, Robert F Sidonio, Michael R Debaun, Monika M Safford, Thomas H Howard, Isabel C Scarinci
Several sickle cell clinical trials have closed due to inability to enroll patients. To limit the early cessation of a proposed clinical trial due to low accrual rates, we sought to better understand ...Read More
H L Lee, Tran Vu Phong, A Rohani
This study was conducted to determine the inhibitory effects of ribavirin and hydroxyurea on dengue virus replication in Aedes aegypti mosquitoes. Female Ae. aegypti mosquitoes were infected with deng...Read More
A Goubella, A Thooft, P Antoine, J Creteur, J-L Vincent
A pseudo-hyperkalemia may occur with hyperleukocytosis. It is important to recognize it early to avoid unnecessary or even dangerous treatment inducing hypokalemia. The pseudohyperkalemia is due to ce...Read More
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JAK2V617F allele burden was prospectively measured in polycythemia vera (PV, n=52) and essential thrombocythemia (ET, n=39) patients receiving hydroxycarbamide (HC) and analyzed according to JAK2 46/1...Read More
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G G Lassmann, L L Thelander, A A Gr?slund
The reaction of the functional tyrosyl radical in protein R2 of ribonucleotide reductase from E. coli and mouse with the enzyme inhibitor hydroxyurea has been studied by EPR stopped-flow techniques at...Read More
S P Hendricks, C K Mathews
Hydroxyurea inhibits DNA synthesis by destroying the catalytically essential free radical of class I ribonucleoside diphosphate (rNDP) reductase, thereby blocking the de novo synthesis of deoxyribonuc...Read More
C Y CY Gui, C C Jiang, H Y HY Xie, R L RL Qian
Hydroxyurea has been used to synchronize cultured cells to S-phase and used to treat patients with sickle-cell anemia. Recently, we found that hydroxyurea can induce the apoptosis of HEL (human erythr...Read More
J W JW Yarbro
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