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5-碘-2'-脱氧尿苷

产品编号 I101755 | CAS号 54-42-2 | 阿拉丁
5-Iodo-2′-deoxyuridine
99%
组合的产品项目
货号 规格 库存 价格 数量
I101755-1g 99% 上海(>10)
北方(预计3-5个工作日)
 
I101755-25g 99% 上海(1)
北方(预计3-5个工作日)
 
I101755-5g 99% 上海(5)
北方(预计3-5个工作日)
 
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属性

敏感性 对空气敏感,对光敏感
旋光率 30 ° (C=1, 1mol/L NaOH)
密度 2.1000
熔点 194°C
存贮条件 储存温度2-8℃,充氩保存

描述

产品介绍 Idoxuridine is a cytotoxic, anti-viral thymidine analog.
别名 5-碘代-2'-脱氧尿嘧啶核苷;5'-碘-2-去氧尿核苷;2'-脱氧-5-碘-尿核苷疱疹净;IDU;IDU; Idoxuridine; 5-Iododesoxyuridine; 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil; 2′-Deoxy-5-iodouridine; 5-IUdR IdUrd Idoxuridine
应用 A cytotoxic analog of thymidine, antiviral
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标识符号 GHS07 GHS07, GHS08 GHS08
信号词 Warning
风险声明 (欧洲) 45,46,61
安全声明(欧洲) 53,45
警示性声明 P261,P281,P305+P351+P338
危害码(欧洲) T
危害声明 H315,H319,H335,H341,H361
个人防护设备 Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges
RTECS YU7700000
WGK德国 3
Merck Index 4891
参考文献
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
Johan Neyts, Erik Verbeken, Erik De Clercq
There is a concern that there may be unregistered stocks of smallpox that can be used for bioterrorism or biological warfare. According to the WHO Advisory Committee on Variola Research, there is a ne...Read More
Pietro P Taverna, Hwa-Shin HS Hwang, Jane E JE Schupp, Tomas T Radivoyevitch, Nancy Nguyen NN Session, Guru G Reddy, David A DA Zarling, Timothy J TJ Kinsella
5-Iodo-2'-deoxyuridine (IdUrd) is a halogenated thymidine analogue recognized as an effective in vitro and in vivo radiosensitizer in human cancers. IdUrd-related cytotoxicity and/or radiosensiti...Read More
Philippe A Coucke, E Cottin, David Azria, Pierre Martineau, Florence Adamer, Laurent A Decosterd, Franz Buchegger, Huu Phuoc Do
(E)-2^'-Deoxy-2^'-(fluoromethylene) cytidine (FMdC), an inhibitor of ribonucleotide diphosphate reductase (RR), is a potent radiation-sensitiser acting through alterations in the deoxyribonu...Read More
Tatiana Rodríguez-Pérez, Susana Fernández, Yogesh S Sanghvi, Mervi Detorio, Raymond F Schinazi, Vicente Gotor, Miguel Ferrero
Phosphodiester linked conjugates of various nucleosides such as d4U, d4T, IdUrd, ddI, ddA, virazole, ara-A, and ara-C containing a glucosyl moiety have been described. These compounds were designed to...Read More
Zander
Trimethoprim/sulfamethoxazole (SXT), alone and in combination with rifampicin (RIF), is a therapeutic option against Staphylococcus aureus, including strains expressing meticillin resistance. However,...Read More
Mark N Prichard, Earl R Kern
The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridin...Read More
Qiuwei Pan, Anna M Nicholson, Hugh Barr, Lea-Anne Harrison, George D Wilson, Julia Burkert, Rosemary Jeffery, Malcolm R Alison, Leendert Looijenga, Wey-Ran Lin, Stuart A C McDonald, Nicholas A Wright, Rebecca Harrison, Maikel P Peppelenbosch, Janusz A Jan
The existence of slowly cycling, adult stem cells has been challenged by the identification of actively cycling cells. We investigated the existence of uncommitted, slowly cycling cells by tracking 5-...Read More
Natalina Salmaso, John Silbereis, Mila Komitova, Patrick Mitchell, Katherine Chapman, Laura R Ment, Michael L Schwartz, Flora M Vaccarino
Premature children born with very low birth weight (VLBW) can suffer chronic hypoxic injury as a consequence of abnormal lung development and cardiovascular abnormalities, often leading to grave neuro...Read More
John M Akudugu, Edouard I Azzam, Roger W Howell
This study uses a three-dimensional cell culture model to investigate lethal bystander effects in human breast cancer cell cultures (MCF-7, MDA-MB-231) treated with (125)I-labeled 5-iodo-2 -deoxyuridi...Read More
Johan J Vande Voorde, Federico F Gago, Kristof K Vrancken, Sandra S Liekens, Jan J Balzarini
In the present paper we demonstrate that the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and show that the phosphorol...Read More
Koshi K Murata, Maki M Imai, Shigetada S Nakanishi, Dai D Watanabe, Ira I Pastan, Kazuto K Kobayashi, Tomoko T Nihira, Hideki H Mochizuki, Shuichi S Yamada, Kensaku K Mori, Masahiro M Yamaguchi
In the olfactory bulb (OB), loss of preexisting granule cells (GCs) and incorporation of adult-born new GCs continues throughout life. GCs consist of distinct subsets. Here, we examined whether the lo...Read More
Hailun Ma, Yunkun Ma, Wenbin Ma, Dhanya K Williams, Teresa A Galvin, Arifa S Khan
Endogenous retroviral sequences are present in high copy numbers in the genomes of all species and may be expressed as RNAs; however, the majority are defective for virus production. Although virus ha...Read More
Joseph P JP Dugas, Marie E ME Varnes, Erno E Sajo, Christopher E CE Welch, Kyungmin K Ham, Kenneth R KR Hogstrom
Purpose: To measure and compare Chinese hamster ovary cell survival curves using monochromatic 35-keV photons and 4-MV x-rays as a function of concentration of the radiosensitizer iododeoxyuridine (IU...Read More
María Llorens-Martín, Gonzalo S Tejeda, José L Trejo
Adult hippocampal neurogenesis (AHN) augments after environmental enrichment (EE) and it has been related to some of the anxiolytic, antidepressant and neuroprotective effects of EE. Indeed, it has be...Read More
Christoph Beyer, Hans-Achim Wagenknecht
Oligonucleotides that contain a 5-iodo-2'-deoxyuridine in the sequence can be applied for a postsynthetic "click"-type modification with ethynyl-modified nile red as a fluorescent label...Read More
N V NV Komissarova, A A AA Tiunova, K V KV Anokhin
The aim of the present work was to study the role of DNA synthesis in the formation of different types of memory in neonatal chicks. The nucleotide analogs 5'-iodo-2'-deoxyuridine (IdU) and ...Read More
Johannes Zander, Silke Besier, Hanns Ackermann, Thomas A Wichelhaus
The antimicrobial activities of folic acid antagonists are supposed to be antagonized by elevated extracellular thymidine concentrations in damaged host tissues. Therefore, this study was aimed at scr...Read More
Rebecca A Frum, Zakaria S Khondker, David G Kaufman
We have recently shown that replication forks pause near origins in normal human fibroblasts (NHF1-hTERT) but not glioblastoma T98G cells. This observation led us to question whether other differences...Read More
Julia J Rousseau, Jean Fran?ois JF Adam, Pierre P Deman, Ting Di TD Wu, Jean Luc JL Guerquin-Kern, Barbara B Gouget, Rolf F RF Barth, Fran?ois F Estève, Hélène H Elleaume
Iodine-enhanced synchrotron stereotactic radiotherapy takes advantage of the radiation dose-enhancement produced by high-Z elements when irradiated with mono-energetic beams of synchrotron X-rays. In ...Read More
Freija Verdoodt, Maxime Willems, Ineke Dhondt, Wouter Houthoofd, Wim Bert, Winnok H De Vos
Platyhelminthes are highly attractive models for addressing fundamental aspects of stem cell biology in vivo. These organisms possess a unique stem cell system comprised of neoblasts that are the only...Read More
Omar Mamlouk, Pichumani Balagurumoorthy, Ketai Wang, S James Adelstein, Amin I Kassis
To investigate the ability of human lymphocytes labeled with DNA-incorporated (125)I to exert an inhibitory (antiproliferative) bystander effect on co-cultured human colon adenocarcinoma LS174T cells ...Read More
Joon Hyung JH Cho, Kevin H KH Shaughnessy
In this unit, an efficient method for the synthesis of alkyne-modified nucleosides in an aqueous solvent system is described. The method allows direct palladium-catalyzed alkynylation of readily avail...Read More
Irina V Panyutin, Rhoda Eniafe, Igor G Panyutin, Ronald D Neumann
Human embryonic stem cells (hESC) hold a great potential for regenerative medicine because, in principle, they can differentiate into any cell type found in the human body. In addition, studying the e...Read More
D D Viertl, F F Perillo-Adamer, P-A PA André, S M SM Ametamey, T L TL Ross, M M Kosinski, Y M YM Dupertuis, A A Bischof Delaloye, F F Buchegger
5-fluoro-2'-deoxyuridine (FdUrd) depletes the endogenous 5'-deoxythymidine triphosphate (dTTP) pool. We hypothesized whether uptake of exogenous dThd analogues could be favoured through a fe...Read More
Alex H Tuttle, Matthew M Rankin, Monica Teta, Daniel J Sartori, Geneva M Stein, Gina J Kim, Cristina Virgilio, Anne Granger, Di Zhou, Simon H Long, Alisa B Schiffman, Jake A Kushner
Accurate measurement of cell division is a fundamental challenge in experimental biology that becomes increasingly complex when slowly dividing cells are analyzed. Established methods to detect cell d...Read More
Su Jin SJ Jang, Joo Hyun JH Kang, Kwang Il KI Kim, Tae Sup TS Lee, Yong Jin YJ Lee, Kyo Chul KC Lee, Kwang Sun KS Woo, Wee Sup WS Chung, Hee Chung HC Kwon, Chun Jeih CJ Ryu, Tae Hyun TH Choi, Chang Woon CW Choi, Sang Moo SM Lim, Gi Jeong GJ Cheon
Lentiviral vector containing the HSV1-tk and firefly luciferase (fLuc) gene was infected into C6 and C6-TL expressing HSV1-tk and fLuc gene was generated. C6-TL showed higher [^1^2^5I]IVDU uptake than...Read More
Jan J Kajstura, Konrad K Urbanek, Shira S Perl, Toru T Hosoda, Hanqiao H Zheng, Barbara B Ogórek, Jo?o J Ferreira-Martins, Polina P Goichberg, Carlos C Rondon-Clavo, Fumihiro F Sanada, Domenico D D'Amario, Marcello M Rota, Federica F Del Monte, Donal
The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by different laboratories varies from none to nearly 20% per ...Read More
Esther G C Troost, Johan Bussink, Piet J Slootweg, Wenny J M Peeters, Matthias A W Merkx, Albert J van der Kogel, Wim J G Oyen, Johannes H A M Kaanders
Accelerated tumor cell repopulation is an important mechanism adversely affecting therapeutic outcome in head and neck cancer. The noninvasive assessment of the proliferative state of a tumor by PET m...Read More
Benedetta Leuner, Erica R Glasper, Elizabeth Gould
Adult neurogenesis is often studied by labeling new cells with the thymidine analog bromodeoxyuridine (BrdU) and using immunohistochemical methods for their visualization. Using this approach, conside...Read More
Xuesen X Fan, Xinying X Zhang, Longhu L Zhou, Kathy A KA Keith, Mark N MN Prichard, Earl R ER Kern, Paul F PF Torrence
Two privileged drug scaffolds have been hybridized to create the novel heteromorphic nucleoside 5-(2-amino-3-cyano-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)-1-(2-deoxypentofuranosyl)pyrimidine-2,4(1H,...Read More
Aliuska Morales AM Helguera, J E JE Rodríguez-Borges, Xerardo X García-Mera, Franco F Fernández, M Natália D S MN Cordeiro
The cancer research community has begun to address the in silico modeling approaches, such as quantitative structure-activity relationships (QSAR), as an important alternative tool for screening poten...Read More
Mark N Prichard, Kathy A Keith, Mary P Johnson, Emma A Harden, Alexis McBrayer, Ming Luo, Shihong Qiu, Debasish Chattopadhyay, Xuesen Fan, Paul F Torrence, Earl R Kern
The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were iden...Read More
Federico Focher, Andrea Lossani, Annalisa Verri, Silvio Spadari, Andrew Maioli, Joseph J Gambino, George E Wright, Richard Eberle, Darla H Black, Peter Medveczky, Maria Medveczky, David Shugar
Herpes B virus (B virus [BV]) is a macaque herpesvirus that is occasionally transmitted to humans where it can cause rapidly ascending encephalitis that is often fatal. To understand the low susceptib...Read More
Francisco J Prado-Prado, Octavio Martinez de la Vega, Eugenio Uriarte, Florencio M Ubeira, Kuo-Chen Chou, Humberto González-Díaz
One limitation of almost all antiviral Quantitative Structure-Activity Relationships (QSAR) models is that they predict the biological activity of drugs against only one species of virus. Consequently...Read More
M N Prichard, D C Quenelle, C B Hartline, E A Harden, G Jefferson, S L Frederick, S L Daily, R J Whitley, K N Tiwari, J A Maddry, J A Secrist, E R Kern
A series of 4'-thionucleosides were synthesized and evaluated for activities against orthopoxviruses and herpesviruses. We reported previously that one analog, 5-iodo-4'-thio-2'-deoxyur...Read More
E R Kern, M N Prichard, D C Quenelle, K A Keith, K N Tiwari, J A Maddry, J A Secrist
As part of a program to identify new compounds that have activity against orthopoxviruses, a number of 4'-thionucleosides were synthesized and evaluated for their efficacies against vaccinia and ...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More