|溶解性||Soluble in DMSO (23 mg/ml at 25 °C), ethanol (23 mg/ml at 25 °C), chloroform (~222.22 mg/ml), water (~200 mg/ml), and methanol.|
|产品介绍||A JAK/STAT signaling pathway inhibitor|
|别名||甲巯咪唑;1-甲基咪唑-2-硫醇;甲硫咪唑;1-Methyl-2-imidazolethiol; Methimazole; 1-Methylimidazole-2-thiol; Thiamazole; 2H-Imidazole-2-thione; 1,3-Dihydro-1-methyl-2H-imidazole-2-thione|
|生化机理||Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.|
|个人防护设备||Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges|
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Higher dose of methimazole causes frequent adverse effects in the management of Graves' disease in children and adolescents.
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Thyrotoxic periodic paralysis with graves' disease leading to the discovery of a hidden nonclassic 11β hydroxylase deficiency.
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To elucidate whether incidence of malformation related to 'methimazole (MMI) embryopathy' ...Read More
Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA.
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Inhibition of iodine organification and regulation of follicular size in rat thyroid tissue in vitro.
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