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2-巯基-1-甲基咪唑

产品编号 M106466 | CAS号 60-56-0 | Aladdin
2-Mercapto-1-methylimidazole
98%
组合的产品项目
货号 规格 库存 价格 数量
M106466-100g 98% 上海(预计3-7周)
北方(预计3-7周)
 
M106466-25g 98% 上海(>10)
北方(预计3-5个工作日)
 
M106466-5g 98% 上海(>10)
北方(2)
 
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属性

密度 1.2800
熔点 145°C
沸点 280°C
溶解性 Soluble in DMSO (23 mg/ml at 25 °C), ethanol (23 mg/ml at 25 °C), chloroform (~222.22 mg/ml), water (~200 mg/ml), and methanol.

描述

产品介绍 A JAK/STAT signaling pathway inhibitor
别名 甲巯咪唑;1-甲基咪唑-2-硫醇;甲硫咪唑;1-Methyl-2-imidazolethiol; Methimazole; 1-Methylimidazole-2-thiol; Thiamazole; 2H-Imidazole-2-thione; 1,3-Dihydro-1-methyl-2H-imidazole-2-thione
生化机理 Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
应用 用于甲亢原料药。
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标识符号 GHS07 GHS07, GHS08 GHS08
信号词 Warning
风险声明 (欧洲) R43;R62;R63
安全声明(欧洲) S36/37
警示性声明 P280
危害码(欧洲) Xn
危害声明 H317,H361
个人防护设备 Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS NI8615000
WGK德国 3
Merck Index 5971
参考文献
Nicole R van Veenendaal, B?rbel Ulmer, Marko T Boskovski, Xiefan Fang, Mustafa K Khokha, Christopher C Wendler, Martin Blum, Scott A Rivkees
Antithyroid medications are the preferred therapy for the treatment of Graves' disease during pregnancy. Propylthiouracil (PTU) is favored over methimazole (MMI) due to potential teratogenic conc...Read More
Jing Yang, Jing Zhong, Xin-Hua Xiao, Ling-Zhi Zhou, Ya-Jun Chen, Jiang-Hua Liu, Ren-Xian Cao, Ge-Bo Wen
This study is aimed to explore the relationship between bone marrow characteristics and clinical prognosis of antithyroid drug (ATD) induced agranulocytosis. A retrospective study was conducted in the...Read More
Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani
Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted appr...Read More
R Scott RS Obach, Franco F Lombardo, Nigel J NJ Waters
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...Read More
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Joelle Malek, Adele Chedraoui, Damian Nikolic, Neda Barouti, Samer Ghosn, Ossama Abbas
Melasma is an acquired hyperpigmentation skin disorder in sun-exposed areas. It occurs almost exclusively over the face, and is most commonly seen in women. Several depigmenting agents have been used ...Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
Tiago L Moda, Carlos A Montanari, Adriano D Andricopulo
We're sorry this abstract is currently not available....Read More
Gustav G Ahlin, Johan J Karlsson, Jenny M JM Pedersen, Lena L Gustavsson, Rolf R Larsson, P?r P Matsson, Ulf U Norinder, Christel A S CA Bergstr?m, Per P Artursson
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In t...Read More
Minjun M Chen, Vikrant V Vijay, Qiang Q Shi, Zhichao Z Liu, Hong H Fang, Weida W Tong
Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effec...Read More
Sean S Ekins, Dayna C DC Mankowski, Dennis J DJ Hoover, Michael P MP Lawton, Judith L JL Treadway, H James HJ Harwood
CYP51 fulfills an essential requirement for all cells, by catalyzing three sequential mono-oxidations within the cholesterol biosynthesis cascade. Inhibition of fungal CYP51 is used as a therapy for t...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
M R Khara, S I Pavlovych, V M Mykha?liuk
In experiments on sexually mature rats we studied specific cholinergic regulations of the heart and the degree of its structural damage in hypothyroidism, depending on gender and hormone-productive ac...Read More
E E Fontana, P M PM Dansette, S M SM Poli
The inhibition of human cytochrome P450s (CYPs) is one of the most common mechanisms which can lead to drug-drug interactions. The inhibition of CYPs can be reversible (competitive or non-competitive)...Read More
Kirsten M Bessembinders, J M Mariska Brinkers, Paul D van der Linden, Kris van Keulen, Jeroen J J de Sonnaville
Agranulocytosis is a rare but dreaded side-effect of thiamazole. A 61-year-old woman presented at the emergency department with fever and dyspnoea. Because she had recently started therapy with thiama...Read More
Stijn L J Van Herck, Stijn Geysens, Edward Bald, Grazyna Chwatko, Evelyne Delezie, Elham Dianati, R G Ahmed, Veerle M Darras
Methimazole (MMI) is an anti-thyroid drug used in the treatment of chronic hyperthyroidism. There is, however, some debate about its use during pregnancy as MMI is known to cross the mammalian placent...Read More
Hirokazu Sato, Nozomu Sasaki, Kanshi Minamitani, Masanori Minagawa, Itsuro Kazukawa, Shigetaka Sugihara, Kunio Wataki, Susumu Konda, Hiroaki Inomata, Kazunori Sanayama, Yoichi Kohno
Methimazole (MMI) is used as a first-line antithyroid drug in children and adolescents with Graves' disease (GD). The aim of this study was to evaluate the correlation between the initial dose of...Read More
Claudia Alva-Sánchez, Jorge Pacheco-Rosado, Tomás Fregoso-Aguilar, Iván Villanueva
OBJECTIVES: We evaluated the contribution of the thyroid hormones to the long-term maintenance of feeding behavior and body weight, while distiguishing their direct central effects from those resultin...Read More
M Schott
Thyrotoxicosis is mainly caused by autonomous adenomas of the thyroid gland and by Graves' disease. A less frequent cause for thyrotoxicosis is Hashimoto's thyroiditis. Thyrotoxicosis in aut...Read More
Prakash Sharma, Reynaldo Pati?o
We examined associations between thyroid condition, gonadal sex and pubertal development in zebrafish. Seventy-two-hour postfertilization larvae were reared in untreated medium or in the presence of g...Read More
Ye-Jee Lim, Tae-Seo Sohn, Seung-Hun Kang, Kyung-Yoon Chang, Bo-Kyung Kim, Yeon-Ji Kim, Won-Chul Ha, Su-Jin Oh, Hyun-Shik Son
Abstract The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital disorder characterized by aplasia of the uterus and the upper part of the vagina in an XX individual with normal developmen...Read More
Coralie C Leblicq, Michel M Duval, Lionel L Carmant, Guy G Van Vliet, Nathalie N Alos
A 15-year-old girl presented with chorea as a first sign of Graves' hyperthyroidism. Chorea abated with antithyroid drug treatment and reappeared when hyperthyroidism recurred but not when thyrot...Read More
Mahdi Khorshidi-Behzadi, Houman Alimoradi, Shaghayegh Haghjoo-Javanmard, Mohammad Reza Sharifi, Nastaran Rahimi, Ahmad Reza Dehpour
Not much has been reported about the effects of hyperthyroidism and its correction on resistance vessels, and just two inconsistent studies have investigated the impacts of restored euthyroidism on va...Read More
Rosa Vissenberg, Mari?tte Goddijn, Ben Willem Mol, Joris A van der Post, Eric Fliers, Peter H Bisschop
Hypothyroidism and hyperthyroidism are associated with maternal and neonatal pregnancy complications. Hypothyroidism should be treated with levothyroxine. Hyperthyroidism requires treatment with propy...Read More
Naoko N Momotani, Saika S Iwama
In the treatment of pregnant patients with Graves' disease, propylthiouracil is preferred over methimazole in early pregnancy because of a possible teratogenicity of methimazole. Methimazole is p...Read More
P Menaut, D J Connolly, A Volk, C Pace, V Luis Fuentes, J Elliott, H Syme
To assess the influence of thyroid function on natriuretic peptide concentration in hyperthyroid cats before and after treatment.Serum natriuretic peptide concentration was measured in 61 hyperthyroid...Read More
Marcus V Leit?o de Souza, Fernanda Satake Novaes
Jaundice related to thyrotoxicosis and not as an effect of antithyroid drugs is a rare complication that usually occurs in the presence of heart failure (HF) or hepatitis. We report a case of a 54-yea...Read More
Devin W Steenkamp, Ana Junqueira, Lewis E Braverman
We're sorry this abstract is currently not available....Read More
Aroop A Pal, Margaret M Le, Leland L Graves
We're sorry this abstract is currently not available....Read More
Mal-Soon Shin, Il-Gyu Ko, Sung-Eun Kim, Bo-Kyun Kim, Tae-Soo Kim, Shin-Ho Lee, Dong-Sup Hwang, Chang-Ju Kim, Jin-Kook Park, Baek-Vin Lim
Thyroid hormones play a crucial role in new neuron production and maturation during brain development. Physical exercise is known to promote cell survival and functional recovery after brain injuries....Read More
Jin Hwa Kim, Geon Park, Sang Yong Kim, Hak Yeon Bae
11β hydroxylase deficiency (OHD) is one of the main causes of congenital adrenal hyperplasia. There have been only a few reported cases of nonclassic 11β OHD, a milder form of the disease. It is dif...Read More
S Lionaki, G Vlachopanos, A Georgalis, P Ziakas, H Gakiopoulou, C Petra, J Boletis
A 78 year old white male on methimazole due to Grave's thyroiditis presented with acute renal failure after a short term history of progressive shortness of breath, malaise, myalgias, arthralgias...Read More
Naoko N Arata
To elucidate whether incidence of malformation related to 'methimazole (MMI) embryopathy' is increasing associated with exposure to MMI in the first 12 gestational weeks, Graves' women(...Read More
Duygu Yeniceli, Xiaolan Deng, Erwin Adams, Dilek Dogrukol-Ak, Ann Van Schepdael
A selective and low-cost CD-MEKC method under acidic conditions was developed for investigating the N-oxygenation of tamoxifen (TAM) by flavin-containing monooxygenases (FMOs). The inhibitory effects ...Read More
Takuji Yasude, Dai Kishida, Ko-Ichi Tazawa, Masayuki Matsuda, Wataru Ishii, Masahide Yazaki, Shu-Ichi Ikeda
A 63-year-old woman suddenly developed central retinal artery occlusion following a slight fever while being treated with methimazole (MMI) for hyperthyroidism. She was diagnosed to have anti-neutroph...Read More
F S Boretti, N S Sieber-Ruckstuhl, S Sch?fer, C Baumgartner, B Riond, R Hofmann-Lehmann, C E Reusch
Transdermal methimazole is an acceptable alternative to oral treatment for hyperthyroid cats. There are, however, no studies evaluating the duration of T4 suppression after transdermal methimazole app...Read More
Samira Seifi, Saeed Nazifi, Mohammad Reza Tabandeh, Mehdi Saeb
The aim of this study was to examine whether the relative gene expression of AdipoR1 and AdipoR2 in rat adipose tissue is altered by thyroid hormones, and whether this might relate to their circulatin...Read More
Francesco Isaia, M Carla Aragoni, Massimiliano Arca, Francesco Demartin, Francesco A Devillanova, Giovanni Floris, Alessandra Garau, Michael B Hursthouse, Vito Lippolis, Rosaria Medda, Fabio Oppo, Marilena Pira, Gaetano Verani
The antithyroid drug methimazole (MMI) reacts with molecular iodine to form, in a multistep process, 1-methylimidazole as final product. In this process, the charge transfer complex MMI-I 2 and the io...Read More
Debasis Das, Gouriprasanna Roy, Govindasamy Mugesh
Synthesis and biological activity of the antithyroid drug carbimazole (CBZ) and its analogues are described. The introduction of an ethoxycarbonyl group in methimazole and its selenium analogue not on...Read More
Kurt S Roser, Paul S Brookes, Andrew P Wojtovich, Leif P Olson, Jalil Shojaie, Richard L Parton, M W Anders
Mitochondrial reactive oxygen species (ROS) generation and the attendant mitochondrial dysfunction are implicated in a range of disease states. The objective of the present studies was to test the hyp...Read More
C K Atterwill, G Hillier
Noxythiolin (Noxyflex-S) inhibited iodide organification (thyroid hormone synthesis) by cultured porcine thyrocytes in vitro after 5 hr (IC50 approx. 9.0 microM). The positive control, the anti-thyroi...Read More
C Glaser, U Marti, M E Bürgi-Saville, C Ruchti, M Gebauer, M W Büchler, H Gerber, U Bürgi, H J Peter
The factors mediating the accumulation of thyroglobulin are of great importance to the understanding of the pathogenesis of human and experimentally induced colloid goiters. To elucidate further the u...Read More
Robert J Greenstein, Liya Su, Sheldon T Brown
Thyrotoxicosis is conceptualized as an "autoimmune" disease with no accepted infectious etiology. There are increasingly compelling data that another "autoimmune" affliction, Crohn...Read More