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Synthesis, pharmacological screening, quantum chemical and in vitro permeability studies of N-Mannich bases of benzimidazoles through bovine cornea
A novel series of N-Mannich bases of benzimidazole derivatives were synthesized and characterized by ^1H NMR, IR spectral studies and elemental analysis. The compounds were screened for analgesic and ...Read More
Molecular modeling of some 1H-benzimidazole derivatives with biological activity against Entamoeba histolytica: A comparative molecular field analysis study
CoMFA models that explain the amoebicidal activity of tautomeric benzimidazole derivatives were developed....Read More
Colocalization of microtubules and mitochondria in the yeast Schizosaccharomyces japonicus var. versatilis.
Both living and fixed cells of Schizosaccharomyces japonicus var. versatilis showed thread-like mitochondria when studied by phase-contrast and fluorescence microscopy. In the interphase cells, mitoch...Read More
Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity.
A new series of novel benzimidazole derivatives containing substituted pyrid-2-yl moiety and polyhydroxy sugar conjugated to the N-benzimidazole moiety has been synthesized and evaluated as orally bio...Read More
Molecular structure and vibrational spectra of 2- and 5-methylbenzimidazole molecules by density functional theory
The FT-IR and FT-Raman spectra of 2-methylbenzimidazole (2-MB) and 5-methylbenzimidazole (5-MB) molecules have been recorded between 400-4000cm^-^1 and 50-3500cm^-^1 region, respectively. The molecula...Read More
The bacterial cell division protein FtsZ is a structural analogue of tubulin. Bacterial mutants in which the ftsZ gene is inactivated are unable to divide. Numerous inhibitors of tubulin assembly are ...Read More
Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos).
Seven modulators of mammalian monooxygenase activity were screened for their ability to selectively stimulate or inhibit in vitro monooxygenase activities of hepatic microsomes from mallard ducklings ...Read More
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Synthesis and inhibitory activity of new benzimidazole derivatives against Burkitt's lymphoma promotion.
As a continuation to our previous work concerning antitumor benzimidazoles, we have synthesized series of new derivatives of 2-(1-benzyl-2-methyl-1H-benzimidazol-5-ylimino)-3-(substituted)-thiazolidin...Read More