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4-甲基咪唑

产品编号 M112296 | CAS号 822-36-6 | Aladdin
4-Methylimidazole
98%
组合的产品项目
货号 规格 库存 价格 数量
M112296-100g 98% 上海(>10)
北方(5)
 
M112296-25g 98% 上海(>10)
北方(>10)
 
M112296-500g 98% 上海(3)
北方(预计3-5个工作日)
 
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属性

敏感性 易吸潮,对空气敏感
密度 1.0200
熔点 56°C
沸点 263°C
存贮条件 储存温度2-8℃,充氩保存

描述

产品介绍 溶于水和乙醇。有腐蚀性。
别名 5-甲基咪唑;4-甲基甘哑啉;4-甲基-1H-咪唑;5-Methylimidazole; 4-Methyl-1H-imidazol; Methyl-1H-imidazole
应用 用作环氧树脂的固化剂、药品西咪替丁的主要原料,还可用于合成抗菌剂等。
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标识符号 GHS05 GHS05, GHS07 GHS07
信号词 Danger
风险声明 (欧洲) R34;R21/22
安全声明(欧洲) S26;S36/37/39;S45
警示性声明 P280,P305+P351+P338,P310
危害码(欧洲) C
危害声明 H302,H312,H314
个人防护设备 Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS NI7350000
WGK德国 2
闪点(摄氏) >112℃
UN代码 3263
参考文献
Linheng Wei, Ziliang Wang, Xianggao Meng
Cocrystallization of imidazole or 4-methylimidazole with 2,2'-dithiodibenzoic acid from methanol solution yields the title 2:1 and 1:1 organic salts, 2C(3)H(5)N(2)(+).C(14)H(10)O(4)S(2)(2-), (I),...Read More
S Javadian, R Araghi
A computational investigation was carried out to characterize the (14)N and (2)H electric field gradient, EFG, in four protonated forms of 4-methyl imidazole (4-MeIm) and Histidine. In an attempt to e...Read More
Wei Gu, Volkhard Helms
Dynamic protonation equilibria in water of one 4-methylimidazole molecule as well as for pairs and groups consisting of 4-methylimidazole, acetic acid and bridging water molecules are studied using Q-...Read More
P C Chan, G D Hill, G D Hills, G E Kissling, A Nyska
4-Methylimidazole (4MI) is used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, cleaning and agricultural chemicals, and rubber. It has been identified as a by-produc...Read More
4-Methylimidazole is used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, cleaning and agricultural chemicals, and rubber. It has been identified as a by-product of f...Read More
L L Lojková, B B Klejdus, J J Moravcová, V V Kubán
Two polar analytes, 4(5)-methylimidazole (4-MeI) and 2-acetyl-4(5)-(1,2,3,4)-tetrahydroxybutyl-imidazole (THI), were extracted with supercritical carbon dioxide (CO2) modified with aqueous methanol. T...Read More
Ileana I Elder, Chingkuang C Tu, Li-June LJ Ming, Robert R McKenna, David N DN Silverman
In the site-specific mutant of human carbonic anhydrase in which the proton shuttle His64 is replaced with alanine, H64A HCA II, catalysis can be activated in a saturable manner by the proton donor 4-...Read More
Kwang-Geun Lee, Haewon Jang, Takayuki Shibamoto
Aqueous caramel model systems consisted the D-glucose/NH(3)/sulphite were heated at 100°C for 2 h and amounts of carcinogenic 4(5)-methylimidazole (4-MI) formed were determined. The amount formed ran...Read More
Holger M Becker, Michael Klier, Christina Schüler, Robert McKenna, Joachim W Deitmer
Carbonic anhydrases (CAs) catalyze the reversible hydration of CO(2) to HCO(3)(-) and H(+). The rate-limiting step in this reaction is the shuttle of protons between the catalytic center of the enzyme...Read More
Tore Sivertsen, Ann-Kristin Nygaard, Gro Mathisen, Frode Fonnum
4-methylimidazole (4MeI) is a tremorogenic and convulsive agent of concern both in human and veterinary toxicology. The in vitro effects of 4MeI (5 microM-20 mM) on cerebral glutamate decarboxylase (G...Read More
Jinyuan J Wang, William C WC Schnute
An ultrahigh-performance liquid chromatography (UHPLC) tandem mass spectrometric (MS/MS) method was developed for the simultaneous quantification of 2-acetyl-4-tetrahydroxybutylimidazole (THI), 2- and...Read More
Kathryn E Muratore, Markus A Seeliger, Zhihong Wang, Dina Fomina, Johnathan Neiswinger, James J Havranek, David Baker, John Kuriyan, Philip A Cole
Protein tyrosine kinases are critical cell signaling enzymes. These enzymes have a highly conserved Arg residue in their catalytic loop which is present two residues or four residues downstream from a...Read More
Po Chan, Joel Mahler, Greg Travlos, Abraham Nyska, M Wenk
Fifteen-day and 14-week studies of 2-methylimidazole (2MI) and 4-methylimidazole (4MI) were conducted because of widespread human exposure via ingestion of food products containing the compounds and l...Read More
Satoshi Ueda, Mingjuan Su, Stephen L Buchwald
The completely N(1)-selective Pd-catalyzed arylation of unsymmetric imidazoles with aryl halides and triflates is described. This study showed that imidazoles have a strong inhibitory effect on the in...Read More
Cédric C Moretton, Gérard G Crétier, Henri H Nigay, Jean-Louis JL Rocca
4-Methylimidazole (4MeI) is a nitrogen compound formed during the manufacture of class III and IV caramel colors. The European Commission has limited its content to 250 ppm. Two methods were compared ...Read More
F Jay Murray
4-Methylimidazole (4-MEI) is found in a wide array of food products. The National Toxicology Program (NTP) recently conducted a two-year feeding cancer bioassay of 4-MEI in B6C3F"1 mice and F344/...Read More
Patrick R Porubsky, Kathleen M Meneely, Emily E Scott
Human microsomal cytochrome P-450 2E1 (CYP2E1) monooxygenates > 70 low molecular weight xenobiotic compounds, as well as much larger endogenous fatty acid signaling molecules such as arachidonic ac...Read More
Shinji Hashimoto, Hideo Takeuchi
Ultraviolet resonance Raman (UVRR) spectroscopy has been used to characterize the structure and hydrogen bonding state of the distal histidine (His42) in horseradish peroxidase (HRP) complexed with ca...Read More
Arijit Roy, Srabani Taraphder
We have investigated the possible proton transfer pathways from the surface of the protein to the zinc-bound water molecule in the mutant His-64-Ala of human carbonic anhydrase II. Starting with an in...Read More
Borivoj Klejdus, Jitka Moravcová, Lea Lojková, Jan Vacek, Vlastimil Kubán
A method for the simultaneous determination of 4(5)-methylimidazole (4MeI) and 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)-imidazole (THI) was developed using SPE and HPLC/MS. Solid-phase extraction usi...Read More