产品编号 N113910 | CAS号 56-57-5 | 阿拉丁
4-Nitroquinoline N-oxide
货号 规格 库存 价格 数量
N113910-1g 98% 上海(>10)
N113910-250mg 98% 上海(>10)
N113910-5g 98% 上海(8)


密度 1.4200
熔点 154-156°C
溶解性 Solubility in water: . Solubility in other solvents: soluble in acetone, DMSO, DMF
存贮条件 储存温度:-20°C


别名 1-氧化-4-硝基喹啉;4-硝基喹啉氧化物;4-硝基氮氧化喹啉;4-NQO;4-Nitroquinoline 1-oxide;4-NQO;4-nitro-1-oxidoquinolin-1-ium
应用 用于有机合成。
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标识符号 GHS08 GHS08
信号词 Danger
风险声明 (欧洲) 45
安全声明(欧洲) 53,45
警示性声明 P201,P308+P313
危害码(欧洲) T
危害声明 H350
个人防护设备 Eyeshields,Gloves,type P2 (EN 143) respirator cartridges
RTECS VC2100000
WGK德国 3
I E Due?as-García, L F Santos-Cruz, L Casta?eda-Partida, A N Casta?eda-Sortibrán, M G Ordaz-Téllez, A Sánchez-Santos, A Durán-Díaz, R Rodríguez-Arnaiz, M E Heres-Pulido
Sulforaphane (SF) is an isothiocyanate present in Brassicaceae, vegetables that induce the detoxification of electrophiles and reactive oxygen species. SF has been correlated with chemoprevention mech...Read More
Anna Mandinova, Karine Lefort, Alice Tommasi di Vignano, Wesley Stonely, Paola Ostano, Giovanna Chiorino, Haruhi Iwaki, Jotaro Nakanishi, G Paolo Dotto
Notch signalling has an important role in skin homeostasis, promoting keratinocyte differentiation and suppressing tumorigenesis. Here we show that this pathway also has an essential anti-apoptotic fu...Read More
Naohiko Kodo, Toshiro Matsuda, Syuichi Doi, Hiroshi Munakata
Yeast cells can extrude intracellular drugs through membrane-associated efflux pumps, such as ATP-binding cassette (ABC) transporters and members of the major facilitator superfamily. Gene expression ...Read More
Do-Hee Choi, Rina Lee, Sung-Hun Kwon, Sung-Ho Bae
Maintenance of genome stability in eukaryotes involves a number of conserved proteins, including RecQ helicases, which play multiple roles at various steps in homologous recombination and DNA repair p...Read More
Akira Ohkoshi, Takafumi Suzuki, Masao Ono, Toshimitsu Kobayashi, Masayuki Yamamoto
Cancers in the upper aerodigestive tract, including cancers of the tongue and the esophagus, are the third leading cause of cancer-related deaths in the world, and oxidative stress is well recognized ...Read More
David J Feith, Anthony E Pegg, Louise Y Y Fong
Upper aerodigestive tract (UADT) cancers of the oral cavity and esophagus are a significant global health burden, and there is an urgent need to develop relevant animal models to identify chemoprevent...Read More
Maria Lobikin, Brook Chernet, Daniel Lobo, Michael Levin
Cancer may result from localized failure of instructive cues that normally orchestrate cell behaviors toward the patterning needs of the organism. Steady-state gradients of transmembrane voltage (V(me...Read More
Jing Li, Feixin Liang, Dahai Yu, Haiyun Qing, Yiping Yang
Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma. However, regional lymph node metastasis from oral cancer has barely been investigated in 4-nitroq...Read More
Dimitris Avgoustidis, Themistoklis Nisyrios, Emeka Nkenke, Roger Lijnen, Vassilis Ragos, Despina Perrea, Ismini Donta, Apostolia Vaena, Christos Yapijakis, Eleftherios Vairaktaris
In an effort to assess the role of plasminogen activator inhibitor-1 (PAI-1) in oral squamous cancer development and progression, two different carcinogen treatment protocols were conducted.Protocol I...Read More
Ashok Kumar Pandurangan, Srinivasan Periasamy, Suresh Kumar Anandasadagopan, Sudhandiran Ganapasam, Shyamala Devi Chennam Srinivasalu
4-Nitroquinoline 1-oxide (4-NQO) a potent oral carcinogen, widely used for induction of oral carcinogenesis, has been found to induce lipid peroxidation in vivo and in vitro. Green tea contains a high...Read More
Masamitsu M Shimazu, Teruhiro T Itaya, Pongsanat P Pongcharoen, Takayuki T Sekito, Miyuki M Kawano-Kawada, Yoshimi Y Kakinuma
Vba5p is closest to Vba3p in the vacuolar transporter for basic amino acids (VBA) family of Saccharomyces cerevisiae. We found that green fluorescence protein (GFP)-tagged Vba5p localized exclusively ...Read More
Daniella Fernandes Mendon?a, Roger Chammas, Fu-Tong Liu, Suely Nonogaki, Sergio Vitorino Cardoso, Adriano Mota Loyola, Paulo Rogério de Faria
Galectin-3 has been implicated in the tumor development via its mediation of the Wnt signaling pathway. Likewise, glycogen synthase kinase-3beta (GSK3β) also plays a role in the Wnt signaling pathway...Read More
Seo Young SY Bang, Jeong Hoon JH Kim, Phil Young PY Lee, Kwang-Hee KH Bae, Jong Suk JS Lee, Pan-Soo PS Kim, Do Hee do H Lee, Pyung Keun PK Myung, Byoung Chul BC Park, Sung Goo SG Park
Nitroreductases comprise a group of FMN- or FAD-dependent enzymes that reduce nitrosubstituted compounds by using NAD(P)H, and are found in bacterial species and yeast. Although there is little inform...Read More
Ramesh K Wali, Dhananjay P Kunte, Mart De La Cruz, Ashish K Tiwari, Jeffrey Brasky, Christopher R Weber, Tina P Gibson, Amir Patel, Suzana D Savkovic, Bruce E Brockstein, Hemant K Roy
Head and neck squamous cell carcinoma (HNSCC) is a major cause of morbidity and mortality underscoring the need for safe and effective chemopreventive strategies. Targeting epidermal growth factor rec...Read More
J Peter Svensson, Rebecca C Fry, Emma Wang, Luis A Somoza, Leona D Samson
Studies in Saccharomyces cerevisiae show that many proteins influence cellular survival upon exposure to DNA damaging agents. We hypothesized that human orthologs of these S. cerevisiae proteins would...Read More
Anna-Maria A De Costa, Danielle N Justis, Corinne A Schuyler, M Rita I Young
The use of dendritic cell (DC) vaccines as treatment for malignancy is complicated by immune evasion tactics often employed by carcinomas such as head and neck squamous cell carcinoma (HNSCC). The pre...Read More
Yu-Ching YC Liu, Heng-Chien HC Ho, Miau-Rong MR Lee, Kuang-Chi KC Lai, Chung-Min CM Yeh, Yueh-Min YM Lin, Tin-Yun TY Ho, Chien-Yun CY Hsiang, Jing-Gung JG Chung
The purpose of this study was to identify the genes induced early in murine oral carcinogenesis. Murine tongue tumors induced by the carcinogen, 4-nitroquinoline 1-oxide (4-NQO), and paired non-tumor ...Read More
Sung-Min Moon, Mee-Young Ahn, Seong-Min Kwon, Soo-A Kim, Sang-Gun Ahn, Jung-Hoon Yoon
Aberrant expression of homeobox genes (HOX), normally required for the differentiation of a particular tissue, has been reported in several types of cancer, but poorly addressed in oral squamous cell ...Read More
Beno?t Le BL Tallec, Anne A Peyroche
Most mutants affected either in the proteasome biogenesis or function accumulate polyubiquitylated proteins and display growth defects at 37°C or in the presence of canavanine, an arginine analog tha...Read More
Juliana G JG Carvalho, Juliana J Noguti, Victor Hugo P VH da Silva, Rogério A RA Dedivitis, Marcello M Franco, Daniel A DA Ribeiro
The aim of this study was to evaluate alkylation induced genotoxicity as a result of DNA repair deficiency during 4-nitroquinoline 1-oxide (4NQO)-induced rat tonguecarcinogenesis by means of single ce...Read More
Ming Zhang, Xuewei Qiao, Liang Zhao, Lu Jiang, Fazheng Ren
Probiotics and carcinogens both have a significant effect on the microfloral composition of the human intestine. The objective of this study was to investigate the impact of an important carcinogen, 4...Read More
Francesca F Trotta, Giovanna G Caldini, Luca L Dominici, Ermanno E Federici, Rosanna R Tofalo, Maria M Schirone, Aldo A Corsetti, Giovanna G Suzzi, Giovanni G Cenci
Yeasts isolated from Italian beverages and foods (wine and cheeses) were identified as Saccharomyces cerevisiae and Debaryomyces hansenii by sequencing the D1/D2 domain of the 26S rRNA gene and differ...Read More
Kshiti B KB Anjaria, Nagesh N NN Bhat, Kapil B KB Shirsath, B B Sreedevi
The modifying effect of butylated hydroxytoluene (BHT) on 60Co gamma radiation and 4-nitro-quinoline 1-oxide-induced gene conversion and back mutation frequencies was investigated using diploid yeast ...Read More
Yian Wang, Ruisheng Yao, Song Gao, Weidong Wen, Yinqiu Du, Eva Szabo, Ming Hu, Ronald A Lubet, Ming You
In this study, we evaluated chemopreventive efficacy of Antitumor B, a Chinese herbal mixture of six plants (Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus arvensis L., Dictamnus ...Read More
Leon F LF Stankowski, Daniel J DJ Roberts, Hepei H Chen, Timothy T Lawlor, Marie M McKeon, Hemalatha H Murli, Ajit A Thakur, Yong Y Xu
As part of the Stage III Pig-a multilaboratory validation trial, we examined the induction of CD59-negative reticulocytes and total red blood cells (RET(CD59-) and RBC(CD59-) , respectively) in male S...Read More
Ting-Hui Chu, Cheng-Chieh Yang, Chung-Ji Liu, Mann-Tin Lui, Shu-Chun Lin, Kuo-Wei Chang
miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directl...Read More