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1-萘异硫氰酸酯

¥ 399.00

产品编号 N137779 | CAS号 551-06-4 | 阿拉丁
1-Naphthyl isothiocyanate
用于HPLC衍生化, ≥98.5% (HPLC and GC)
组合的产品项目
货号 规格 库存 价格 数量
N137779-1g 用于HPLC衍生化, ≥98.5% (HPLC and GC) 上海(8)
北方(预计3-5个工作日)
 
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属性

敏感性 对湿度敏感
密度 1.1100
熔点 55°C
溶解性 不溶于水,易溶于苯、丙酮、乙醚、热乙醇。

描述

别名 萘基芥子油;异硫氰酸1-萘酯;1-异硫氰酸萘酯;1-异硫代氰酸萘基酯;α-萘异硫氰酸酯;α-萘基硫代异氰酸酯;Isothiocyanic Acid 1-Naphthyl Ester
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标识符号 GHS06 GHS06, GHS08 GHS08
信号词 Danger
风险声明 (欧洲) R23/24/25;
安全声明(欧洲) S22;S24/25;S45;
警示性声明 P261,P280,P301+P310,P305+P351+P338,P342+P311
危害码(欧洲) T
危害声明 H301,H312,H315,H319,H332,H334,H335
个人防护设备 Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges
RTECS NX9100000
是否危化品 一般危险品
参考文献
Xin X Tong, Hui H Sun, Guang-li GL Yan, Wei W Dong, Wen-jun WJ Sun, Yang Y Yu, Ping P Wang, Ying Y Han, Xi-jun XJ Wang
To ascertain the biomarkers capable to characterize the animal composite model of Chinese medicine (CM) yinhuang syndrome induced by triplet factors of rhubarb, ethanol, and α-nephthylisothiolyanate ...Read More
Han-Jin HJ Park, Jung-Hwa JH Oh, Se-Myo SM Park, Jae-Woo JW Cho, Young Na YN Yum, Sue Nie SN Park, Do-Young DY Yoon, Seokjoo S Yoon
Toxicogenomic approaches have been applied to chemical-induced heptocarcinogenesis rodent models for the identification of biomarkers of early-stage hepatocarcinogenesis and to help clarify the underl...Read More
James P Luyendyk, Karen M Kassel, Katryn Allen, Grace L Guo, Guodong Li, Glenn H Cantor, Bryan L Copple
Chronic cholestatic liver injury induced by cholestasis in rodents is associated with hepatic fibrin deposition, and we found evidence of fibrin deposition in livers of patients with cholestasis. Key ...Read More
James P Luyendyk, Kevin C Flanagan, C David Williams, Hartmut Jaeschke, Joyce G Slusser, Nigel Mackman, Glenn H Cantor
Cholestatic liver injury induced by alpha-naphthylisothiocyanate (ANIT) is provoked by injury to intrahepatic bile ducts and the progression of hepatic necrosis requires the procoagulant protein tissu...Read More
James P Luyendyk, Nigel Mackman, Bradley P Sullivan
Alpha-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury causes tissue factor (TF)-dependent coagulation in mice, and TF deficiency reduces ANIT-induced liver injury. However, the mechanis...Read More
N N Mori, T T Yokooji, Y Y Kamio, T T Murakami
The intestinal absorption of mizoribine, an imidazole nucleoside, is mediated by concentrative nucleoside transporter (CNT)1 and CNT2 in rat. Previously, bile and bile salts such as sodium glycocholat...Read More
Masanori Kobayashi, Satonori Higuchi, Katsuhiko Mizuno, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi
Drug-induced liver injury (DILI) is a major safety concern in drug development and clinical drug therapy. The pathogenesis of DILI usually involves the participation of the parent drug or metabolites ...Read More
Fang Zhou, Hongmei Xu
To investigate the effect and mechanism of emodin on acute intrahepatic cholestasis induced by alpha-naphthylisothiocyanate (ANIT) in rats.Acute cholestatic model in rats was induced by ANIT. Normal c...Read More
John Michael JM Cullen, James Greg JG Falls, Harlan Roger HR Brown, Lawrence Wonsik LW Yoon, Neal Foster NF Cariello, Brenda B Faiola, Carie Lynette CL Kimbrough, Holly Lynn HL Jordan, Richard Thomas RT Miller
Acute toxic responses to a 50-mg/kg oral dose of 1-naphthylisothiocyanate (ANIT) were evaluated by microarray analysis of laser capture-microdissected rat biliary epithelium or hepatic parenchyma obta...Read More
Jun-Lan JL Lv, Rui-Sheng RS Li, Shi-Ying SY Jin, Hai-Long HL Yuan, Shan-Shan SS Fu, Jin J Han, Shi-Xiao SX Jin, Xiao-He XH Xiao
To study the changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate (ANIT)-induced experimental hepatic injury after oral administration of Yinchenhao Deco...Read More
Fan Yang, Ying Xu, Aizhen Xiong, Yugi He, Li Yang, Yu-Jui Yvonne Wan, Zhengtao Wang
To evaluate the hepatoprotective effect of the root and rhizome of Rhubarb (Rhei Radix et Rhizoma) against α-naphthylisothiocyanate (ANIT)-induced liver injury using metabolic profile of bile acids (...Read More
Ping Yang, Peng Chen, Tao Wang, Yibei Zhan, Mengyi Zhou, Lin Xia, Rui Cheng, Yating Guo, Lin Zhu, Jianfa Zhang
Cholestasis has limited therapeutic options and is associated with high morbidity and mortality. The A(1 ) adenosine receptor (A ( 1 ) AR) was postulated to participate in the pathogenesis of hep...Read More
John M Cullen, Brenda Faiola, David H Melich, Richard A Peterson, Holly L Jordan, Carie L Kimbrough, Judith S Prescott, Richard T Miller
Depletion of Kupffer cells, known to modulate chemical-induced hepatocellular injury, has not been studied with regard to biliary epithelial injury. Here, the authors investigated the effect of Kupffe...Read More
Juhyun Park, Hyo-Yeon Kim, Sun-Mee Lee
This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl(4))-, D-galactosamine (GalN)- and α-naphthylisothiocyanate (ANIT)-in...Read More
Tao T Liu, Xinjin X Guo, Qiang Q Meng, Changyuan C Wang, Qi Q Liu, Huijun H Sun, Xiaochi X Ma, Taiichi T Kaku, Kexin K Liu
The objective was to determine whether protective effects of JBP485 on biliary obstruction induced by alpha-naphthylisothiocyanate (ANIT) are mediated by the organic anion transporters Oat1, Oat3 and ...Read More
Bo Kong, Iván L Csanaky, Lauren M Aleksunes, Meghan Patni, Qi Chen, Xiaochao Ma, Hartmut Jaeschke, Scott Weir, Melinda Broward, Curtis D Klaassen, Grace L Guo
Emerging evidence suggests that feeding a high-fat diet (HFD) to rodents affects the expression of genes involved in drug transport. However, gender-specific effects of HFD on drug transport are not k...Read More
Li-Li LL Ding, Bin-Feng BF Zhang, Wei W Dou, Li L Yang, Chang-Sen CS Zhan, Zheng-Tao ZT Wang
Danning tablet, as a composite prescription of traditional Chinese medicine, has been used clinically to relieve liver and gallbladder diseases in China. However, the mechanisms involved are still unc...Read More
Bhavana S Solanky, Gina J Sanchez-Canon, Jeremy F L Cobbold, Simon D Taylor-Robinson, Jimmy D Bell, Cheryl L Scudamore, Eleanor Ross, Julie C Holder, Po-Wah So, I Jane Cox
Certain human diseases affecting the biliary tree can be modeled in rats by ingestion of the hepatobiliary toxin alpha-naphthylisothiocyanate (ANIT). Phosphorus magnetic resonance spectroscopy (MRS) a...Read More
Bradley P Sullivan, Wei Cui, Bryan L Copple, James P Luyendyk
Hepatic expression of the transcription factor early growth response-1 (Egr-1) is increased in livers of patients with cholestatic liver disease. Bile acid induction of inflammatory genes in hepatocyt...Read More
Igor I Sukhotnik, Hila H Razon, Yulia Y Pollak, Lili L Hayari, Jacob J Bejar, Jorge G JG Mogilner, Karl G KG Sylvester
Progressive hyperbilirubinemia and end-stage liver failure are among the most serious complications of short bowel syndrome (SBS), representing the principle cause of death in a majority of fatal case...Read More
Matthew Quinn, Yoshiyuki Ueno, Hae Yong Pae, Li Huang, Gabriel Frampton, Cheryl Galindo, Heather Francis, Darijana Horvat, Matthew McMillin, Sharon Demorrow
Cholestatic patients often present with clinical features suggestive of adrenal insufficiency. In the bile duct-ligated (BDL) model of cholestasis, the hypothalamic-pituitary-adrenal (HPA) axis is sup...Read More
Hossain M HM Golbar, Takeshi T Izawa, Ryo R Yano, Chisa C Ichikawa, Osamu O Sawamoto, Mitsuru M Kuwamura, Jonathan J Lamarre, Jyoji J Yamate
To investigate pathogenesis of post-bile duct (BD) injury fibrosis, interlobular BD epithelial injury was induced in male F344 rats by a single IP injection of α-naphthylisothiocyanate (75 mg/kg body...Read More
Christina M Van Itallie, James M Anderson
Tight junctions restrict the paracellular movement of ions, solutes, drugs, and larger material across epithelia and endothelia. For practical purposes, the barrier can be modeled as having two compon...Read More
Bradley P Sullivan, Ruipeng Wang, Ossama Tawfik, James P Luyendyk
Alpha-naphthylisothiocyanate (ANIT) causes cholestatic hepatitis characterized by intrahepatic bile duct epithelial cell injury and periportal hepatocellular necrosis. The progression of ANIT-induced ...Read More
Keith A Thatch, Michael S Katz, Marian M Haber, Marshall Z Schwartz
Purpose: Dependence on total parenteral nutrition in intestinal failure or short bowel syndrome patients can lead to many complications. The most significant complication is progressive liver injury l...Read More

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