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Bioelectrochemical probing of intracellular redox processes in living yeast cells--application of redox polymer wiring in a microfluidic environment.
Conventionally, microbial bioelectrochemical assays have been conducted using immobilized cells on an electrode that is placed in an electrochemical batch cell. In this paper, we describe a developed ...Read More
Glycoproteins participate in various biological events, including disease progression. Currently, there is a pressing need for development of new simple and inexpensive methods for glycoprotein carboh...Read More
A library of 29 organoosmium compounds has been built up with known and novel cyclometalated compounds obtained with C-N, NCN, and CNN ligands. All compounds have been tested for their in vitro cytoto...Read More
The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway.
Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X](+) where M = Ru(II) or Os(II) and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells. Not...Read More
C-H Bond Activation of the Methyl Group of the Supporting Ligand in an Osmium(III) Complex upon Reaction with H(2)O(2): Formation of an Organometallic Osmium(IV) Complex.
Oxidation of the hydroxoosmium(III) complex resulted in C-H bond activation of the methyl group of the supporting ligand (N,N'-dimethyl-2,11-diaza[3.3](2,6)pyridinophane). The product was an osmi...Read More
Red-light-induced inhibition of DNA replication and amplification by PCR with an os/rh supramolecule.
Bimetallic: Upon irradiation with light in the phototherapeutic window, the bimetallic complex [(bpy)(2) Os(dpp)RhCl(2) (phen)](3+) binds to and cleaves DNA through an oxygen-independent mechanism. P...Read More
Electrochemical communication between micro-organisms and electrodes is the integral and fundamental part of BESs (bioelectrochemical systems). The immobilization of bacterial cells on the electrode a...Read More
An osmium(III)/osmium(V) redox couple generating Os(V)(O)(OH) center for cis-1,2-dihydroxylation of alkenes with H2O2: Os complex with a nitrogen-based tetradentate ligand.
For the synthesis of the 1,2-diols, cis-1,2-dihydroxylation of alkenes catalyzed by osmium(VIII) tetroxide (OsO(4)) is a powerful method. However, OsO(4) is quite toxic due to its highly volatile and ...Read More
N-(4-toluenesulfonyloxy)carbamates based on a range of common amine protecting groups serve as preformed nitrogen sources in the intermolecular osmium-catalyzed oxyamination reaction of a variety of m...Read More
Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.
Synthesis of the indenotryptoline bisindole alkaloid, BE-54017, was accomplished using osmium-promoted cis-dihydroxylation of maleimide as a key step. After optical resolution, the absolute configurat...Read More
Reactions of an osmium-hexahydride complex with cytosine, deoxycytidine, and cytidine: the importance of the minor tautomers.
Complex OsH(6)(P(i)Pr(3))(2) (1) deprotonates cytosine to give molecular hydrogen and the d(4)-trihydride derivative OsH(3)(cytosinate)(P(i)Pr(3))(2) (2), which in solution exists as a mixture of isom...Read More
Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity.
A one-pot synthesis of osmium(IV) complexes with two different tautomers of indazole, 1H-indazole and 2H-indazole, namely (H(2)ind)[Os(IV)Cl(5)(2H-ind)] (1) and (H(2)ind)[Os(IV)Cl(5)(1H-ind)] (2) is r...Read More
Complex F?rster energy transfer interactions between semiconductor quantum dots and a redox-active osmium assembly.
The ability of luminescent semiconductor quantum dots (QDs) to engage in diverse energy transfer processes with organic dyes, light-harvesting proteins, metal complexes, and redox-active labels contin...Read More
A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines.
A series of ruthenium(II) arene complexes with 3-(1H-benzimidazol-2-yl)-1H-quinoxalin-2-one, bearing pharmacophoric groups of known protein kinase inhibitors, and related benzoxazole and benzothiazole...Read More
Mediated glucose enzyme electrodes by cross-linking films of osmium redox complexes and glucose oxidase on electrodes.
Here, we report on a novel, versatile approach for the preparation of mediated enzyme electrodes, demonstrated using cross-linked films of glucose oxidase and a range of functionalised osmium complexe...Read More
Mediated electron transfer of cellobiose dehydrogenase and glucose oxidase at osmium polymer-modified nanoporous gold electrodes.
Nanoporous and planar gold electrodes were utilised as supports for the redox enzymes Aspergillus niger glucose oxidase (GOx) and Corynascus thermophilus cellobiose dehydrogenase (CtCDH). Electrodes m...Read More
Ionic self-assembly of electroactive biorecognizable units: electrical contacting of redox glycoenzymes made easy.
This work explores the synergistic combination of ionic self-assembly and recognition-directed assembly for the modification of electrode surfaces with redox glycoenzymes on the basis of electroactive...Read More
Ligand-incorporation site in 5-methylcytosine-detection probe modulating the site of osmium complexation with the target DNA.
ICON Probes, short DNA strands containing an adenine linked to a bipyridine ligand, formed an interstrand cross-link with 5-methylcytosine located opposite the modified adenine in the presence of an o...Read More
Using the well-known exoelectrogen Shewanella oneidensis MR-1, an osmium redox polymer modified anode exhibited ca. 4-fold increase in current generation. Additionally, a significant decrease in the s...Read More
Tunable energy transfer rates via control of primary, secondary, and tertiary structure of a coiled coil peptide scaffold.
Herein we report energy transfer studies in a series of Ru(II) and Os(II) linked coiled-coil peptides in which the supramolecular scaffold controls the functional properties of the assembly. A general...Read More
The reaction of 9,10-phenanthrenequinone (PQ) with [M(II)(H)(CO)(X)(PPh(3))(3)] in boiling toluene leads to the homolytic cleavage of the M(II)-H bond, affording the paramagnetic trans-[M(PQ)(PPh(3))(...Read More
N-h and N-C bond activation of pyrimidinic nucleobases and nucleosides promoted by an osmium polyhydride.
Complex OsH(6)(P(i)Pr(3))(2) (1) reacts with 1-methylthymine and 1-methyluracil to give OsH(3)(P(i)Pr(3))(2)(nucleobase') (2, 3) containing the deprotonated nucleobases (nucleobase') κ(2)-N...Read More
Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.
Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case ...Read More