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盐酸苯肼

产品编号 P104684 | CAS号 59-88-1 | 阿拉丁
Phenylhydrazine hydrochloride
99%
组合的产品项目
货号 规格 库存 价格 数量
P104684-100g 99% 上海(预计3-7周)
北方(5)
 
P104684-25g 99% 上海(>10)
北方(>10)
 
P104684-500g 99% 上海(1)
北方(4)
 
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属性

敏感性 对光,空气和湿度敏感
密度 1.1250
熔点 243-246°C
溶解性 溶于水(50 mg/ml)和乙醇,不溶于醚。
存贮条件 充氩保存

描述

产品介绍 对光和湿敏感。能升华。易溶于水,溶于乙醇,几乎不溶于乙醚。加入浓盐酸则从溶液中析出沉淀。有毒,最小致死量(兔,经口)25mg/kg。有致癌可能性。
别名 苯肼盐酸盐;苯基联氨盐酸盐;肼基苯盐酸盐;苯肼单盐酸盐;Phenylhydrazinium chloride
生化机理 Phenylhydrazine hydrochloride causes acute hemolysis when injected intraperitoneally in to wild-type and Hp and Hx single-null mice. It suppresses the horseradish peroxide (HRP) residual activity in tissue sections of animals.
应用 醛、酮和糖的特殊试剂。主要用于合成农药、医药、染料及合成其它有机物。
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标识符号 GHS06 GHS06, GHS08 GHS08, GHS09 GHS09
信号词 Danger
风险声明 (欧洲) R43;R45;R50;R23/24/25;R36/38;R48/23/24/25
安全声明(欧洲) S45;S53;S61
警示性声明 P201,P261,P273,P280,P301+P310,P305+P351+P338
危害码(欧洲) F,N
危害声明 H301,H311,H315,H317,H319,H331,H341,H350,H372,H400
个人防护设备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS MV9000000
Merck Index 7293
UN代码 2811
参考文献
Robert Moreau, Diane Tshikudi Malu, Mathieu Dumais, Esther Dalko, Véronique Gaudreault, Hugo Roméro, Corine Martineau, Olha Kevorkova, Jaime Sanchez Dardon, Erin Lynn Dodd, David Scott Bohle, Tatiana Scorza
Sustained erythropoiesis and concurrent bone marrow hyperplasia are proposed to be responsible for low bone mass density (BMD) in chronic hemolytic pathologies. As impaired erythropoiesis is also freq...Read More
Nisha Philip, Rachael Orr, Andrew P Waters
Gene manipulation is an invaluable tool to investigate and understand the biology of an organism. Although this technology has been applied to both the human and rodent malarial parasites (RMP), Plasm...Read More
Claudia K?the, Ramona Metzinger, Christian Herwig, Christian Limberg
The reaction of [L(tBu)Ni(OEt(2))] (where L(tBu) = [HC(C(t)BuNC(6)H(3)((i)Pr)(2))(2)](-)) with phenylhydrazine leads to the phenylhydrazido(1-) complex [L(tBu)Ni(η(2)-NPhNH(2))] (1) with concomitant ...Read More
Sasidhar Vemula, Jianjian Shi, Raghuveer Singh Mali, Peilin Ma, Yan Liu, Philip Hanneman, Karl R Koehler, Eri Hashino, Lei Wei, Reuben Kapur
Erythropoiesis is a dynamic, multistep process whereby hematopoietic stem cells differentiate toward a progressively committed erythroid lineage through intermediate progenitors. Although several down...Read More
Sang Hun Lee, Hyung Joo Suh, Hyun-Sun Lee, Yooheon Park, Jang-Woo Park, Eun Young Jung
This study examined the effect of fermentation on the ability of antler to act as a stimulator of hematopoietic activity. Hemolytic anemia was induced by phenylhydrazine (PHZ) in female Sprague-Dawley...Read More
Mona M MM Fahmy, Riham R RR Mohamed, Nadia A NA Mohamed
Biologically active N-benzoyl-4-(N-maleimido)-phenylhydrazide (BMPH) was synthesized and its structure was confirmed by elemental analysis and various spectral tools. It was examined as a thermal stab...Read More
M D MD Powell, M S MS Burke, D D Dahle
Phenylhydrazine injections (0.3 mg kg(-1) , followed by a second injection of 0.1 mg kg(-1) 7 days later) induced a reproducible and stable anaemia in Atlantic halibut Hippoglossus hippoglossus, reduc...Read More
Ahmed A AA Ibrahim, G N GN Dar, Shabi Abbas SA Zaidi, Ahmad A Umar, M M Abaker, H H Bouzid, S S Baskoutas
We report here the fabrication of a robust, highly sensitive, reliable and reproducible phenyl hydrazine chemical sensor using Ag-doped ZnO nanoflowers as efficient electron mediators. The Ag-doped Zn...Read More
David M DM Frazer, Sarah J SJ Wilkins, Deepak D Darshan, Alison C AC Badrick, Gordon D GD McLaren, Gregory J GJ Anderson
The BMP/SMAD signalling pathway plays an important role in iron homeostasis, regulating hepcidin expression in response to body iron levels. However, the role of this pathway in the reduction in hepci...Read More
Claudio Cantù, Francesca Bosè, Paola Bianchi, Eva Reali, Maria Teresa Colzani, Ileana Cantù, Gloria Barbarani, Sergio Ottolenghi, Walter Witke, Laura Spinardi, Antonella Ellena Ronchi
During late differentiation, erythroid cells undergo profound changes involving actin filament remodeling. One of the proteins controlling actin dynamics is gelsolin, a calcium-activated actin filamen...Read More
Aubrey J Cunnington, J Brian de Souza, Michael Walther, Eleanor M Riley
In sub-Saharan Africa, invasive nontyphoid Salmonella (NTS) infection is a common and often fatal complication of Plasmodium falciparum infection. Induction of heme oxygenase-1 (HO-1) mediates toleran...Read More
Prashant Aragade, R Venkat Narayanan, Veeresh Maddi, Pankaj Patil, Prashant Shinde, Mohan Agrawal
A series of 3-[3-(substituted phenyl)-1-phenyl-1H-pyrazol-5-yl]-2H-chromen-2-one (4a-k) were synthesized by reaction of 3-[2,3-dibromo-3-(substituted phenyl)propanoyl]-2H-chromen-2-one (3 a-k) with ph...Read More
Iwona Hirschler-Laszkiewicz, Wenyi Zhang, Kerry Keefer, Kathleen Conrad, Qin Tong, Shu-jen Chen, Sarah Bronson, Joseph Y Cheung, Barbara A Miller
Transient receptor potential (TRP) channels Trpc2 and Trpc3 are expressed on normal murine erythroid precursors, and erythropoietin stimulates an increase in intracellular calcium ([Ca(2+)](i)) throug...Read More
Denham G DG Cook, Rufus M G RM Wells, Neill A NA Herbert
The effect of altered oxygen transport potential on behavioural responses to environmental hypoxia was tested experimentally in snapper, Pagrus auratus, treated with a haemolytic agent (phenylhydrazin...Read More
Jeanne E Hendrickson, Eldad A Hod, Chantel M Cadwell, Stephanie C Eisenbarth, David A Spiegel, Christopher A Tormey, Steven L Spitalnik, James C Zimring
Fourteen-day stored red blood cells (RBCs) containing an RBC-specific transgenic antigen (HOD) induce a recipient proinflammatory cytokine storm and are significantly more immunogenic compared to fres...Read More
Sne?ana D SD Markovi?, Jovana B JB Zi?i?, Ana D AD Obradovi?, Branka I BI Ognjanovi?, A S AS Stajn, Zorica S ZS Sai?i?, M B MB Spasi?
Stimulated erythropoiesis and reticulocytosis can be induced by daily bleeding, or by phenylhydrazine (PHZ) treatment. We compared the in vivo effects of PHZ and bleeding treatment on haematological, ...Read More
Weiwei Huang, Yaping Li, Zhongyue Yang, Hai Lin, Huakuan Lin
A novel colorimetric anion-chemosensor based on 1,10-phenanthroline-2,9-dicarbonyl-p-nitro-phenylhydrazine has been synthesized. Among the different anions tested, it shows the best selectivity toward...Read More
Yi-Ming Sung, Srivardhan Reddy Gayam, Shu-Pao Wu
Tyrosinase was found to catalyze the oxidation of phenylhydrazine to phenol in a reaction that did not resemble those typically performed by tyrosinase. The kinetics of this reaction was investigated ...Read More
Madelyn S Hanson, Hao Xu, Timothy C Flewelen, Sandra L Holzhauer, Dawn Retherford, Deron W Jones, Anne C Frei, Kirkwood A Pritchard, Cheryl A Hillery, Neil Hogg, Nancy J Wandersee
Hemolysis can saturate the hemoglobin (Hb)/heme scavenging system, resulting in increased circulating cell-free Hb (CF-Hb) in hereditary and acquired hemolytic disease. While recent studies have sugge...Read More
Yuji Sonoda, Kazunobu Sasaki
Fetal liver hematopoiesis in mice disappears approximately 2 weeks after birth; however, under experimental acute anemia extramedullary hematopoiesis occurs in the livers of adult mice. The hematopoie...Read More
Patarabutr P Masaratana, Gladys O GO Latunde-Dada, Neeta N Patel, Robert J RJ Simpson, Sophie S Vaulont, Andrew T AT McKie
Hepcidin, an iron regulatory peptide, plays a central role in the maintenance of systemic iron homeostasis by inducing the internalization and degradation of the iron exporter, ferroportin. Hepcidin e...Read More
Jian J Wu, Qing Q Shi, Zhuo Z Chen, Ming M He, Linhong L Jin, Deyu D Hu
Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl ch...Read More
Dagny L Ulrich, John Lynch, Yao Wang, Yu Fukuda, Deepa Nachagari, Guoqing Du, Daxi Sun, Yiping Fan, Lyudmila Tsurkan, Philip M Potter, Jerold E Rehg, John D Schuetz
Abcb6 is a mammalian mitochondrial ATP-binding cassette (ABC) transporter that regulates de novo porphyrin synthesis. In previous studies, haploinsufficient (Abcb6(+/-)) embryonic stem cells showed im...Read More
Diana M DM Gilligan, Greg L GL Finney, Eric E Rynes, Michael J MJ Maccoss, Amy J AJ Lambert, Luanne L LL Peters, Raymond F RF Robledo, Jason M JM Wooden
Hemolytic anemia is one of the most common inherited disorders. To identify candidate proteins involved in hemolytic anemia pathophysiology, we utilized a label-free comparative proteomic approach to ...Read More
Ramesh R Chandra, Santosh S Kumar, S K SK Puri
Malaria is one of the most lethal parasitic infections in the world. The lethality of the parasite depends on the rate of multiplication of the parasite within host erythrocytes. Different strains of ...Read More
Y Yamamura, H Senda, Y Kageyama, T Matsuzaki, M Noda, Y Ikawa
Abnormal erythropoietin (EPO)-independent cell growth is induced after infection of erythroid progenitor cells with a polycythemic strain of Friend virus (FVp). Binding of its Env-related glycoprotein...Read More
Emanuela E Tolosano, Sharmila S Fagoonee, Emilio E Hirsch, Franklin G FG Berger, Heinz H Baumann, Lorenzo L Silengo, Fiorella F Altruda
Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among plasma-protective proteins against oxidative ...Read More