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异硫氰酸苯酯

产品编号 P110636 | CAS号 103-72-0 | 阿拉丁
Phenyl isothiocyanate
99%,用于HPLC标记
组合的产品项目
货号 规格 库存 价格 数量
P110636-5ml 99%,用于HPLC标记 上海(>10)
北方(预计3-5个工作日)
 
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属性

敏感性 对湿度敏感
折光率 1.64918
密度 1.1320
熔点 -21°C
沸点 221°C
溶解性 不溶于水,溶于醇、醚。
存贮条件 需2-8°C 保存

描述

产品介绍 有刺激性气味。对湿敏感。能随水蒸气挥发而不分解。溶于乙醇、乙醚和其他有机溶剂,不溶于水。有毒,半数致死量(小鼠,经口)87mg/kg。有腐蚀性。
别名 苯基芥子油;苯基异硫氰酸酯;硫代异氰酸苯酯;PITC;Isothiocyanic Acid Phenyl Ester
应用 有机分析检定伯胺和腈类。肽顺序研究。用于制药工业和有机合成。色谱衍生化试剂
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标识符号 GHS05 GHS05, GHS06 GHS06, GHS08 GHS08
信号词 Danger
风险声明 (欧洲) R25;R34;R42/43;R51/53
安全声明(欧洲) S23;S26;S36/37/39;S45;S61
警示性声明 P261,P280,P305+P351+P338,P310
危害码(欧洲) T,N
危害声明 H301,H314,H317,H334
个人防护设备 Faceshields,full-face respirator (US),Gloves,Goggles,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter
RTECS NX9275000
WGK德国 3
闪点(摄氏) 87℃
是否危化品 一般危险品
UN代码 1693
参考文献
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
I Azaiez, G Meca, L Manyes, F B Luciano, M Fernández-Franzón
Fumonisins (FBs) are bioactive compounds produced by several strains of Fusarium spp. which contain a polyketide structure similar to sphinganine. These mycotoxins contain a free amino group that coul...Read More
Minas M Stylianakis, Emmanuel Stratakis, Emmanuel Koudoumas, Emmanuel Kymakis, Spiros H Anastasiadis
A solution-processed graphene content was synthesized by treatment of graphite oxide (GO) with phenyl isothiocyanate (PITC) by taking advantage of the functional carboxyl groups of graphene oxide. The...Read More
Yong Y Zhang, Ahmad Ali AA Shaik, Chengguo C Xing, Yubo Y Chai, Li L Li, Jinhui J Zhang, Wei W Zhang, Sung-Hoon SH Kim, Junxuan J Lü, Cheng C Jiang
Targeting androgen receptor (AR) signaling with agents distinct from current antagonist drugs remains a rational approach to the prevention and treatment of prostate cancer (PCa). Our previous studies...Read More
Sarah F SF Wilson, Christopher A CA James, Xiaochun X Zhu, Mike T MT Davis, Mark J MJ Rose
An LC-MS/MS method using pre-column derivatization with phenylisothiocyanate (PITC) was developed to quantify glycine in human cerebrospinal fluid (CSF) and applied to the determination of glycine in ...Read More
Takayuki T Shibata, Moses N MN Wainaina, Takayuki T Miyoshi, Tsutomu T Kabashima, Masaaki M Kai
A method for sequence analysis and identification of phosphoamino acids in peptides based on high performance liquid chromatography (HPLC) is described. The peptides were derivatized with an Edman typ...Read More
Meiling Wang, Guowen Meng, Qing Huang, Mingtao Li, Zhongbo Li, Chaolong Tang
A sensitive and selective fluorescent membrane for rapid detection of trace 2,2',4,5,5'-pentachlorinated biphenyl (PCB101) has been achieved by immobilizing the fluorophore phenyl isothiocya...Read More
Tomoyuki Oe, Masamitsu Maekawa, Ryo Satoh, Seon Hwa Lee, Takaaki Goto
This manuscript describes the results of a preliminary experiment performed as 'proof of concept' of a novel approach to absolute quantitation of proteins without the use of standard protein...Read More
Nora N Graf, Andreas A Lippitz, Thomas T Gross, Falko F Pippig, Andreas A Holl?nder, Wolfgang E S WE Unger
The determination of amino groups on surfaces capable of binding biomolecules is important for the understanding and optimization of technologically relevant coupling processes. In this study, three d...Read More
Y A Bailey-Shaw, K D Golden, A G M Pearson, R B R Porter
Jamaican agro-industries generate large quantities of wastes, which are either discarded or under-utilized. In order to evaluate the possible utilization of these wastes, it is necessary that the prof...Read More
Vishakantha Murthy, Thomas J Martin, Susy Kim, Huw M L Davies, Steven R Childers
Previous studies have shown that the phenylisothiocyanate tropane analog 2-beta-propanoyl-3-beta-(2-naphthyl)-8-[4-isothiocyanato)benzyl]nortropane (HD-205) binds covalently to dopamine and serotonin ...Read More
E E Fowler, M M Moyer, R G RG Krishna, C C CC Chin, F F Wold
Two enzymatic methods commonly used in N-terminal sequence analysis of blocked proteins are presented in this unit; one uses pyroglutamate aminopeptidase for N(alpha)-pyrrolidone carboxyl-proteins in ...Read More
G G Marrubini, G G Caccialanza, G G Massolini
In the present study, a single HPLC method was developed for the determination of glycine and threonine in cicatrizants. Two different preparations of a cream and an ointment, and the corresponding ba...Read More
Akira A Murakami, Meiyu M Song, Hajime H Ohigashi
Osteoclastogenesis is induced by differentiation of hemopoietic cells of monocyte-macrophage lineage into bone-resorbing osteoclasts. The process is initiated by receptor activator of NF-kappaB ligand...Read More
Vishakantha Murthy, Huw M L Davies, Simon J Hedley, Steven R Childers
Irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (DAT), serotonin (SERT) and norepinephrine (NE...Read More
Simiso S Dube, Mkhululi T MT Khumalo, Nelson N Torto, Jacob A JA Nyati
An MEKC method was developed for the separation and characterization of phenyl-isothiocyanate (PITC)-labeled amino acids derived from Gonometa rufobrunnae silkworm after microdialysis sample cleanup. ...Read More
Jiapeng J Leng, Haoyang H Wang, Li L Zhang, Jing J Zhang, Hang H Wang, Tingting T Cai, Jinting J Yao, Yinlong Y Guo
A multifunctional isothiocyanate-based isotope labeling reagent, [d (0)]-/[d (6)]-4,6-dimethoxy pyrimidine-2-isothiocyanate (DMPITC), has been developed for accurate N-terminus identification in pepti...Read More
Ahmad Faizal AF Abdull Razis, Manuela M Bagatta, Gina Rosalinda GR De Nicola, Renato R Iori, Costas C Ioannides
The potential of three isothiocyanates, namely R,S-sulforaphane, erucin and phenethyl isothiocyanate, of two naturally occurring glucosinolates, namely glucoerucin and glucoraphanin, and of the enanti...Read More
Kristin K Samuelsson, Moa Andresen MA Bergstr?m, Charlotte A CA Jonsson, Gunnar G Westman, Ann-Therese AT Karlberg
Diphenylthiourea (DPTU) is a known skin sensitizer commonly used as a vulcanization accelerator in the production of synthetic rubber, for example, neoprene. The versatile usage of neoprene is due to ...Read More
R R Gheshlaghi, J M JM Scharer, M M Moo-Young, P L PL Douglas
Modified resolution and overall separation factors used to quantify the separation of complex chromatography systems are described. These factors were proven to be applicable to the optimization of am...Read More
Fantao Meng, Belur N Manjula, Paul K Smith, Seetharama A Acharya
Successful and cost-effective PEGylation protocols require pure functionalized PEG reagents, which can be synthesized by simple and efficient procedures, exhibit high stability against hydrolysis, and...Read More
P P Thejass, Girija G Kuttan
Angiogenesis is a crucial step in the growth and metastasis of cancers. The activation of endothelial cells and their further behavior are very critical during angiogenesis. The authors analyze the ef...Read More
R R Thippeswamy, K G Mallikarjun KG Gouda, Devavratha H DH Rao, Asha A Martin, Lalitha R LR Gowda
Two liquid chromatographic methods that involve precolumn derivatization with o-phthaladehyde (OPA) and phenylisothiocyanate (PITC) with fluorescence and diode array UV detection for the determination...Read More
Misako Aito-Inoue, Kozo Ohtsuki, Yasushi Nakamura, Eun Young Park, Koji Iwai, Fumiki Morimatsu, Kenji Sato
For the isolation and detection of food-derived peptides in blood, an approach based on the derivatization of peptides with phenyl isothiocyanate (PITC) was developed. This approach allows hydrophilic...Read More
R L RL Heinrikson, S C SC Meredith
Methods for the quantitative derivatization of amino acids with phenylisothiocyanate and for the separation and quantitation of the resulting phenylthiocarbamyl derivatives by reverse-phase high-perfo...Read More
R F RF Ebert
A method for analysis of phenylthiocarbamyl-amino acids by HPLC is described. Solvent A contains 0.05 M sodium acetate plus triethylamine (2.75 ml/liter) adjusted to pH 6.40 with phosphoric acid. Solv...Read More