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Prednisone

产品编号 P116562 | CAS号 53-03-2 | Aladdin
Prednisone
98%
组合的产品项目
货号 规格 库存 价格 数量
P116562-1g 98% 上海(8)
北方(预计3-5个工作日)
 
P116562-25g 98% 上海(4)
北方(预计3-5个工作日)
 
P116562-5g 98% 上海(6)
北方(预计3-5个工作日)
 
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属性

密度 1.3000
熔点 233-235°C
溶解性 DMSO 72 mg/mL (200 mM); Water <1 mg/mL (<1 mM),
存贮条件 储存温度-20°C

描述

产品介绍 Prednisone 是一种人工合成的皮质类固醇剂,是特别有效的免疫抑制剂的化合物。
别名 泼尼松; 1-可的松; 17Α,21-二羟基-1,4-孕甾二烯-3,11,20-三酮; 去氢可的松; 强的松;Deltasone; 1-Cortisone; Dehydrocortisone; 1,4-Pregnadiene-17a,21-diol-3,11,20-trione; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
应用 Downregulates TNF-α production and NF-κB expression
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标识符号 GHS08 GHS08
信号词 Warning
风险声明 (欧洲) 63
安全声明(欧洲) 36/37/39,45
警示性声明 P281
危害码(欧洲) Xn
危害声明 H361
个人防护设备 Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS TU4154100
WGK德国 3
参考文献
R Scott RS Obach, Franco F Lombardo, Nigel J NJ Waters
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...Read More
Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan
Kidney plays an important role in the elimination of drugs, especially with low or negligible hepatic clearance. An analysis of the interrelation of physicochemical properties and the human renal clea...Read More
Manthena V S MV Varma, R Scott RS Obach, Charles C Rotter, Howard R HR Miller, George G Chang, Stefanus J SJ Steyn, Ayman A El-Kattan, Matthew D MD Troutman
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database comprised ...Read More
S Ekins, A J Williams, J J Xu
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...Read More
Nigel N Greene, Lilia L Fisk, Russell T RT Naven, Reine R RR Note, Mukesh L ML Patel, Dennis J DJ Pelletier
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...Read More
Tiago L Moda, Carlos A Montanari, Adriano D Andricopulo
We're sorry this abstract is currently not available....Read More
Gustav G Ahlin, Johan J Karlsson, Jenny M JM Pedersen, Lena L Gustavsson, Rolf R Larsson, P?r P Matsson, Ulf U Norinder, Christel A S CA Bergstr?m, Per P Artursson
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In t...Read More
Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He
We developed an improved Lombardeo's method (J. Med. Chem., 2004) for prediction of VD"s"s in human. With ElogD substituted by logk"I"A"M, together with f"i" &#...Read More
Jenny M JM Pedersen, P?r P Matsson, Christel A S CA Bergstr?m, Ulf U Norinder, Janet J Hoogstraate, Per P Artursson
The chemical space of registered oral drugs was explored for inhibitors of the human multidrug-resistance associated protein 2 (MRP2; ABCC2), using a data set of 191 structurally diverse drugs and dru...Read More
Zhichao Liu, Qiang Shi, Don Ding, Reagan Kelly, Hong Fang, Weida Tong
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...Read More
Giorgio G Ottaviani, Sophie S Martel, Pierre-Alain PA Carrupt
The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studie...Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
L V Filatova, A A Plotnikova, M L Gershanovich, T Iu Semiglazova
In a retrospective study during the primary mode MOPP to primary patients LH II/IVAB stages with a poor prognosis rate of CR, 5--and 10-year DFS, OS was 69%, 71% and 68%, 74% and 64%, ABVD--76%, 78%, ...Read More
N V Sachivko, é A Zhavrid, E V Baranov, O A Kolenik
In this paper we present the results of a randomized prospective study, in which we examined the influence of rIL-2 ("Ronkoleykin ") on the effectiveness of the R-CHOP combination in the fir...Read More
Yuksel Urun, Duygu Kankaya, Lokman Koral, Bulent Yalcin, Ayca Karabork, Koray Ceyhan, Melih Cem Boruban, Güng?r Utkan, Ahmet Demirkazik
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid follicles. FDCS has been increasingly reported in recent years. However, data on...Read More
Fabrice Jardin, Bertrand Coiffier
In this issue of Blood, Li et al report mutations in the 3′ untranslated region (3′UTR) of TP53 that modify the expression of p53 and thus its effect on response to therapy in diffuse large B-cell...Read More
S Kreissl, P Borchmann
We're sorry this abstract is currently not available....Read More
Eunyoung Lee, Tae Min Kim, Yoojoo Lim, Yoon Kyung Jeon, Heounjeong Go, Chul Woo Kim, Dae Seog Heo
We're sorry this abstract is currently not available....Read More
Minoru Mizutani, Yoshiki Nakamori, Haruna Sakaguchi, Yuki Kageyama, Eiko Oya, Kazuko Ino, Kei Suzuki, Takao Sekine
A 61-year-old woman presented with a right mandibular tumor and was diagnosed with DLBCL clinical stage IIIA from the biopsy results of the tumor and CT examination. An initial rituximab was administr...Read More
S Chaabouni, H Ben Salah Lahiani, L Ghorbel, M Abdelmoula, M Elloumi, J Daoud
The extranodal non-Hodgkin lymphomas of maxillofacial soft tissues are rare. We report two cases of maxillofacial soft tissue non-Hodgkin lymphoma treated with chemotherapy followed by localized radio...Read More
Matthew A Lunning, Alison J Moskowitz, Steven Horwitz
A 69-year-old woman was referred for further evaluation and management of relapsed angioimmunoblastic T-cell lymphoma. At diagnosis, she received six cycles of dose-adjusted EPOCH (etoposide, predniso...Read More
Hyoeun Shim, Jae-Il Oh, Sang Hyuk Park, Seongsoo Jang, Chan-Jeoung Park, Jooryung Huh, Cheolwon Suh, Hyun-Sook Chi
Bone marrow involvement confers a poor prognosis in patients with diffuse, large, B-cell lymphoma (DLBCL). However, the prognostic significance of concordant and discordant bone marrow involvement in ...Read More
David Cunningham, Eliza A Hawkes, Andrew Jack, Wendi Qian, Paul Smith, Paul Mouncey, Christopher Pocock, Kirit M Ardeshna, John A Radford, Andrew McMillan, John Davies, Deborah Turner, Anton Kruger, Peter Johnson, Joanna Gambell, David Linch
Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell...Read More
Wen-Sheng Li, Jian-Lan Xie, Ming Zhang, Xiao-Ge Zhou
We're sorry this abstract is currently not available....Read More
Michele Merli, Margherita Maffioli, Andrea Ferrario, Francesco Passamonti
We're sorry this abstract is currently not available....Read More
Sook-Bin Woo, John H Stone, Stefan Kraft
We're sorry this abstract is currently not available....Read More
Donna Neuberg, Robert J Arceci
We're sorry this abstract is currently not available....Read More
Sotiria Palioura, Adriano Piris, James Chodosh
We're sorry this abstract is currently not available....Read More
Ian F Tannock, Karim Fizazi, Sergey Ivanov, Camilla Thellenberg Karlsson, Aude Fléchon, Iwona Skoneczna, Francisco Orlandi, Gwenaelle Gravis, Vsevolod Matveev, Sevil Bavbek, Thierry Gil, Luciano Viana, Osvaldo Arén, Oleg Karyakin, Tony Elliott, Alison Bir
Docetaxel plus prednisone is standard first-line chemotherapy for men with metastatic castrate-resistant prostate cancer. Aflibercept is a recombinant human fusion protein that binds A and B isoforms ...Read More
Patrick Hakman, Florence Vallelian, Albina Nowak
We're sorry this abstract is currently not available....Read More
D Teodor, Andra Teodor, Lucia Grigore, Gabriela Jug?nariu, Carmen Mihaela Dorob??, Egidia Miftode, Doina Azoic?i
Standard therapy in chronic hepatitis C virus infection is still a combination of peginterferon alfa2a/2b and ribavirin for 48 weeks. As of side effects, there are organic side effects, such as hemato...Read More
Don D Sin, Hye Yun Park
We're sorry this abstract is currently not available....Read More
Valerie M Wong, Candace Marche, Elemir Simko
An 11-week-old, female Alaskan husky dog housed outdoors in the Yukon, Canada, was diagnosed with infectious canine hepatitis. The predisposing factors in this puppy for such a rare disease included i...Read More
Miguel Angel Nadal, Bruno Lococo, Maria Bernarda Fazzini, Gabriela Gonzalez, Alcira Beatriz Otero, Ana Valeria Malvar
Introduction: Treatment of patients with resistant/relapsed adult nephrotic syndrome (RNS) caused by glomerulopathies has no consensus therapy. Objectives: This is a retrospective analysis (RA), perfo...Read More
Tahmeed Contractor, Adrian Bell, Atul Khasnis, Bruce J Silverberg, Matthew W Martinez
Non-bacterial endocarditis lesions associated with antiphospholipid antibodies (aPLs) in the absence of other criteria for antiphospholipid syndrome or systemic lupus erythematosus is termed an aPL-as...Read More
J Sosna
We're sorry this abstract is currently not available....Read More
Christian A Waimann, Maria F Marengo, Sofia de Achaval, Vanessa L Cox, Araceli Garcia-Gonzalez, John D Reveille, Marsha N Richardson, Maria E Suarez-Almazor
To quantify adherence to oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis (RA), using electronic medication monitoring, and to evaluate the clinic...Read More
J?rg D Leuppi, Philipp Schuetz, Roland Bingisser, Michael Bodmer, Matthias Briel, Tilman Drescher, Ursula Duerring, Christoph Henzen, Yolanda Leibbrandt, Sabrina Maier, David Miedinger, Beat Müller, Andreas Scherr, Christian Schindler, Rolf Stoeckli, Seba
International guidelines advocate a 7- to 14-day course of systemic glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, the optimal dose and duratio...Read More
Irina Kenis, Tania Zahavi, Ze'ev Korzets
We're sorry this abstract is currently not available....Read More
Tanja Neuvians
We're sorry this abstract is currently not available....Read More
Angela C Freeman, Ronald J Rapoport
Each of these painful disorders can be challenging to diagnose, and many patients have both. Adequate glucocorticoid dosing and gradual tapering are key to treatment success. ...Read More
Stefanie Schuster, Markus Diethelm
We report the case of a 73 year old patient with a COPD. A severe exazerbation was treated with glucocorticoids and Quinolones. A few days later both ankles were tender and painful. Ultrasound examina...Read More
Francis X McCormack, Clay Wilmott, Lisa R Young, Kathryn Wikenheiser-Brokamp
We're sorry this abstract is currently not available....Read More