|别名||喹哪啶酸 ;喹啉-2-甲酸，2-羧基喹啉;Quinaldic Acid 2-Quinolinecarboxylic Acid|
|个人防护设备||dust mask type N95 (US),Eyeshields,Faceshields,Gloves|
Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...Read More
Hydrogen-bonded frameworks of bis(2-carboxypyridinium) hexafluorosilicate and bis(2-carboxyquinolinium) hexafluorosilicate dihydrate.
In bis(2-carboxypyridinium) hexafluorosilicate, 2C(6)H(6)NO(2)+.SiF6(2-), (I), and bis(2-carboxyquinolinium) hexafluorosilicate dihydrate, 2C(10)H(8)NO(2)+.SiF6(2-).2H2O, (II), the Si atoms of the ani...Read More
Thiostrepton, a powerful antibiotic belonging to the thiopeptide class, was synthesized in the laboratory for the first time in 2004 through an arduous campaign involving novel strategies and tactics,...Read More
Insights into quinaldic acid moiety formation in thiostrepton biosynthesis facilitating fluorinated thiopeptide generation.
Thiostrepton (TSR), often referred as to a parent compound in the thiopeptide family, is a bimacrocyclic member that features a quinaldic acid (QA) moiety-containing side ring appended to the characte...Read More
In this study a one step method for the preparation of substituted anilides of quinoline-2-carboxylic acid was developed. This efficient innovative approach is based on the direct reaction of an acid ...Read More
Synthesis, characterization and crystal structure of novel mononuclear peroxotungsten(VI) complexes. Insulinomimetic activity of W(VI) and Nb(V) peroxo complexes
Two new mononuclear peroxo complexes of tungsten of the formula (gu)"2[WO"2(O"2)"2] (1) and (gu)[WO(O"2)"2(quin-2-c)] (2a) (where gu^+=guanidinium ion, CN"3H"6^...Read More
One-dimensional hydrogen-bonded structures in the 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid with 8-hydroxyquinoline, 8-aminoquinoline and quinoline-2-carboxylic acid (quinaldic acid).
The structures of the 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid with 8-hydroxyquinoline, 8-aminoquinoline and quinoline-2-carboxylic acid (quinaldic acid), namely anhydrous 8-hydroxyq...Read More
4-Carboxyanilinium (2R,3R)-tartrate and a redetermination of the alpha-polymorph of 4-aminobenzoic acid.
In the title compounds, 4-carboxyanilinium (2R,3R)-tartrate, C(7)H(8)NO(2)+.C(4)H(5)O(6)-, (I), and 4-aminobenzoic acid, C(7)H(7)NO(2), (II), the carboxyl planes of the 4-carboxyanilinium cations/4-am...Read More
Microbial metabolism of quinoline and related compounds. XX. Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases.
Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 catalyses the hydroxylation of quinoline 2-carboxylic (quinaldic acid) to 4-hydroxyquinoline 2-carboxylic acid (kynurenic acid) with concomita...Read More
A simple technique has been devised that allows direct plate selection of tetracycline-sensitive clones from a predominantly tetracycline-resistant population. The technique is especially useful in ge...Read More
1-2H-Phthalazine hydrazone (hydralazine; HYD), 2-1H-pyridinone hydrazone (2-hydrazinopyridine; HP), 2-quinoline-carboxylic acid (QCA), 1-isoquinolinecarboxylic acid (IQCA), 2,2'-bi-1H-imidazole (...Read More
Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.
Transcriptional response pathways in a yeast strain sensitive to saframycin a and a more potent analog: evidence for a common basis of activity.
Saframycin A (SafA) is a natural product that inhibits human cancer cell proliferation. Its synthetic analog, QAD, is a more potent inhibitor of these cells. SafA does not affect wild-type yeast, but ...Read More
Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety.
Specifically 13C-labeled quinoline-2-carboxylate derivatives were synthesized from quinoline and used to study the biosynthesis of thiostrepton in a strain of Streptomyces laurentii. 13C NMR analysis ...Read More
Hydroxylation of quinaldic acid: quinaldic acid 4-monooxygenase from Alcaligenes sp. F-2 versus quinaldic acid 4-oxidoreductases.
The N-heterocycles quinaldic acid (quinoline 2-carboxylic acid), kynurenic acid (4-hydroxyquinoline 2-carboxylic acid), 2-oxo-1,2-dihydroquinoline, and xanthine are utilized by Alcaligenes sp. F-2 as ...Read More
[Synthesis and biological properties of pyrimidine 2'-deoxynucleosides modified by a residue of quinaldic acid].
O-Quinaldoyl derivatives of thymidine, 2'-deoxyuridine, and 5-trimethylsilyl-2'-deoxyuridine were synthesized. 5'-Deoxy-5'-(quinoline-2-carbonylamino)- and 5'-deoxy-5'-[(...Read More
Microbial metabolism of quinoline and related compounds. XVIII. Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1.
Serratia marcecens 2CC-1 utilizes quinaldic acid (quinoline 2-carboxylic acid) as sole source of carbon, nitrogen and energy. Growth of strain 2CC-1 on quinaldic acid as well as on nicotinic acid and ...Read More
Induction of ornithine decarboxylase activity in mouse urinary bladder by L-tryptophan and some of its metabolites.
Several conditions of growth of Bordetella pertussis cause a reversible phenotypic alteration in properties termed modulation. Growth in medium containing nicotinic acid induces normal (X-mode) cells ...Read More
Certain products of tryptophan metabolism interact with excitatory amino acid receptors to produce or protect against excitotoxicity. In this study, the action of several tryptophan metabolites, yield...Read More
Ergothioneine is believed not to be synthesized by man but it accumulates to high concentrations in some mammalian cells as a result of dietary intake. Ergothioneine is known to chelate divalent metal...Read More
Inhibition effect of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of the rat.