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正钒酸钠

¥ 66.00

产品编号 S105282 | CAS号 13721-39-6 | Aladdin
Sodium orthovanadate
≥90% (T)
组合的产品项目
货号 规格 库存 价格 数量
S105282-25g ≥90% (T) 上海(预计3-7周)
北方(预计3-7周)
 
S105282-100g ≥90% (T) 上海(预计3-7周)
北方(预计3-7周)
 
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属性

敏感性 对湿度敏感
熔点 866°C
溶解性 Soluble in water (50 mg/ml, clear to hazy, colorless to faint yellow solution).

描述

产品介绍 Sodium orthovanadate is a commonly used general inhibitor for protein tyrosine phosphatases (PTPs), alkaline phosphatase (ALP), and ATPase. Sodium orthovanadate acts as a competitive inhibitor and is completely reversible upon the addition of EDTA or by dilution. The PTP activities are conveniently separable from the protein phosphoseryl and phosphothreonyl phosphatase (PSP) activities inhibited by fluoride and EDTA. Vanadate is routinely used to preserve the protein tyrosyl phosphorylation state in cells, cell lysates, and protein tyrosine kinase assays. Sodium orthovanadate is also an inhibitor of adenosine kinase (AK) and phosphofructokinase (PFK).
别名 正钒酸钠 ;原钒酸钠,钒酸钠 ;sodium tetraoxovanadate; sodium vanadium oxide; trisodium vanadate Sodium orthovanadate dodecahydrate
应用 几种磷酸酶和磷酸激酶的抑制剂
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标识符号 GHS07 GHS07
信号词 Warning
风险声明 (欧洲) R23/24/25
安全声明(欧洲) S24/25
警示性声明 P280
危害码(欧洲) T
危害声明 H302,H312,H332
个人防护设备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves
RTECS YW1120000
WGK德国 3
参考文献
Carmine Giorgio, Iftiin Hassan Mohamed, Lisa Flammini, Elisabetta Barocelli, Matteo Incerti, Alessio Lodola, Massimiliano Tognolini
Eph-ephrin system plays a central role in a large variety of human cancers. In fact, alterated expression and/or de-regulated function of Eph-ephrin system promotes tumorigenesis and development of a ...Read More
J A Gordon
We're sorry this abstract is currently not available....Read More
I R Gibbons, M P Cosson, J A Evans, B H Gibbons, B Houck, K H Martinson, W S Sale, W J Tang
The motility of demembranated sea urchin sperm flagella and that of embryo cilia reactivated with 0.1 mM ATP are completely inhibited by 4 micron and 0.5 micron vanadium(V) [V(V), in vanadate], respec...Read More
G Swarup, K V Speeg, S Cohen, D L Garbers
Homogenization of TCRC-2 cells yielded a phosphotyrosyl-protein phosphatase with a specific activity approximately 10-=fold higher in particulate than in soluble fractions. Over 90% of the phosphotyro...Read More
R P RP Cox, P P Gilbert, M J MJ Griffin
Alkaline phosphatase prepared from mammalian cell cultures was found to have alkaline inorganic pyrophosphatase activity. Both of these activities appear to be associated with a single protein, as dem...Read More
P J PJ Stankiewicz, M J MJ Gresser
The inhibition constants for vanadate, chromate, molybdate, and tungstate have been determined with Escherichia coli alkaline phosphatase, potato acid phosphatase, and Helix pomatia aryl sulfatase. Va...Read More
P P Mu?oz, A A Gumà, M M Camps, M M Furriols, X X Testar, M M Palacín, A A Zorzano
Sodium orthovanadate caused a 2-fold stimulation of system A transport activity in soleus muscle, as assessed by the uptake of the nonmetabolizable analog 2-(methylamino)isobutyric acid (MeAIB). The e...Read More
Y Hayashida, C V Rodriguez, G Ogata, G J Partida, H Oi, T W Stradleigh, S C Lee, A F Colado, A T Ishida
The spike output of neural pathways can be regulated by modulating output neuron excitability and/or their synaptic inputs. Dopaminergic interneurons synapse onto cells that route signals to mammalian...Read More
Jayanta Debnath
Integrin@?mediated cell adhesion to extracellular matrix (ECM) is critical for normal epithelial cell survival; cells deprived of ECM contact rapidly undergo apoptotic cell death, termed anoikis. Rece...Read More
Patrick J PJ Devine, Patricia B PB Hoyer, Aileen F AF Keating
The female reproductive system is important as the site for development and fertilization of an oocyte, for implantation and development of an embryo, and for growth and delivery of the fetus. It also...Read More
G Firaguay, J A Nunes
Many proteins involved in cell signaling are phosphorylated. To determine the phosphorylation status of these signaling molecules at the single-cell level, we present a protocol for using state-specif...Read More
B Schoeberl, E A Pace, J B Fitzgerald, B D Harms, L Xu, L Nie, B Linggi, A Kalra, V Paragas, R Bukhalid, V Grantcharova, N Kohli, K A West, M Leszczyniecka, M J Feldhaus, A J Kudla, U B Nielsen
The signaling network downstream of the ErbB family of receptors has been extensively targeted by cancer therapeutics; however, understanding the relative importance of the different components of the...Read More
Mehmet M Bülbül, Ruken R Tan, Burcu B Gemici, Sebahat S Ozdem, Ismail I Ustünel, Nuray N Acar, V Nimet VN Izgüt-Uysal
Orexin-A (OXA) and orexin receptor type 1 (OX1R) are found in enteric nervous system and smooth muscle cells in the digestive tract. Fasting is a stimulant for OXA synthesis. The aim of the present st...Read More
Chun-Chen Kuo, Chi-Yuan Chu, Jing-Jer Lin, Lee-Chiang Lo
Src homology-2 (SH2) domain-containing phosphatase 2 (SHP2) is known to participate in several different signaling pathways to mediate cell growth, survival, migration, and differentiation. However, d...Read More
Bing Wang, Kaoru Tanaka, Akinori Morita, Yasuharu Ninomiya, Kouichi Maruyama, Kazuko Fujita, Yoshio Hosoi, Mitsuru Nenoi
Previous in vitro and in vivo studies have shown that sodium orthovanadate (vanadate), an inorganic vanadium compound, could effectively suppress radiation-induced p53-mediated apoptosis via both tran...Read More
Zahid M ZM Delwar, Ake A Siden, Mabel H MH Cruz, Juan S JS Yakisich
Exposure of cancer cells to anticancer agents in cultures induces detachment of cells that are usually considered dead. These drug-induced detached cells (D-IDCs) may represent a clinical problem for ...Read More
S S W?lchli, M L ML Curchod, R P RP Gobert, S S Arkinstall, R R Hooft van Huijsduijnen
Many pharmacologically important receptors, including all cytokine receptors, signal via tyrosine (auto)phosphorylation, followed by resetting to their original state through the action of protein tyr...Read More
Steve S Flanagin, Joel D JD Nelson, David G DG Castner, Oleg O Denisenko, Karol K Bomsztyk
The chromatin immunoprecipitation (ChIP) assay is a major tool in the study of genomic processes in vivo. This and other methods are revealing that control of gene expression, cell division and DNA re...Read More
E L Leung, M Fraser, R R Fiscus, B K Tsang
The present study determines if (1) basal protein levels of nitric oxide (NO) synthases (eNOS, iNOS, and nNOS) are different in cisplatin-sensitive (OV2008) and counterpart cisplatin-resistant (C13(*)...Read More
X Wang, R P Rao, T Kosakowska-Cholody, M A Masood, E Southon, H Zhang, C Berthet, K Nagashim, T K Veenstra, L Tessarollo, U Acharya, J K Acharya
Ceramide transfer protein (CERT) functions in the transfer of ceramide from the endoplasmic reticulum (ER) to the Golgi. In this study, we show that CERT is an essential gene for mouse development and...Read More
Suzanna L SL Prosser, Kees R KR Straatman, Andrew M AM Fry
Cancer cells frequently exhibit overduplicated centrosomes that lead to formation of multipolar spindles, chromosome missegregation, and aneuploidy. However, the molecular events involved in centrosom...Read More
Andrea L Moyer, Raniyah T Ramadan, Billy D Novosad, Roger Astley, Michelle C Callegan
The purpose of this study was to determine to what extent blood-retinal barrier (BRB) permeability occurred during experimental Bacillus cereus endophthalmitis and whether tight junction alterations w...Read More
Teresa M Bernaciak, Jessica Zareno, J Thomas Parsons, Corinne M Silva
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Hee Sang Koo, Sung Don Kang, Ju Hwan Lee, Nam-Ho Kim, Hun-Taeg Chung, Hyun-Ock Pae
Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), of which main function is to inactivate the extracellular signal-regulate...Read More
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