|别名||环丁砜 ;噻吩烷砜, 1,1-二氧四氢噻吩,四亚甲基砜,四氢噻吩砜,二氧化噻吩烷,四氢噻吩-1，1-二氧化物,二氧化四氢噻吩,砜茂烷;Tetrahydrothiophene 1,1-dioxide Tetramethylene sulfone|
|个人防护设备||dust mask type N95 (US),Eyeshields,Gloves|
A novel method for quantification of sulfolane (a metabolite of busulfan) in plasma by gas chromatography-tandem mass spectrometry.
The role of busulfan (Bu) metabolites in the adverse events seen during hematopoietic stem cell transplantation and in drug interactions is not explored. Lack of availability of established analytical...Read More
The supercharging effect of sulfolane on cytochrome c (cyt c) during electrospray ionization mass spectrometry (ESI-MS) in the absence of conformational effects was investigated. The addition of sulfo...Read More
The efficacy of dimethyl sulfoxide (DMSO) as a supercharging reagent for protein ions formed by electrospray ionization from aqueous solution and the mechanism for supercharging were investigated. Add...Read More
Improved liquid chromatography-MS/MS of heparan sulfate oligosaccharides via chip-based pulsed makeup flow.
Microfluidic chip-based hydrophilic interaction chromatography (HILIC) is a useful separation system for liquid chromatography-mass spectrometry (LC-MS) in compositional profiling of heparan sulfate (...Read More
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Ion mobility-mass spectrometry of phosphorylase B ions generated with supercharging reagents but in charge-reducing buffer.
We investigate whether "supercharging" reagents able to shift the charge state distributions (CSDs) of electrosprayed protein ions upward also influence gas-phase protein structure. A differ...Read More
New reagents for enhanced liquid chromatographic separation and charging of intact protein ions for electrospray ionization mass spectrometry.
Electrospray ionization produces multiply charged ions, thereby lowering the mass-to-charge ratio for peptides and small proteins to a range readily accessed by quadrupole ion trap, orbitrap, and ion ...Read More
Effects of supercharging reagents on noncovalent complex structure in electrospray ionization from aqueous solutions.
The effects of two supercharging reagents, m-nitrobenzyl alcohol (m-NBA) and sulfolane, on the charge-state distributions and conformations of myoglobin ions formed by electrospray ionization were inv...Read More
The addition of m-nitrobenzyl alcohol (m-NBA) was shown previously (Lomeli et al., J. Am. Soc. Mass Spectrom. 2009, 20, 593-596) to enhance multiple charging of native proteins and noncovalent protein...Read More
Ionic liquids as superior solvents for headspace gas chromatography of residual solvents with very low vapor pressure, relevant for pharmaceutical final dosage forms
1-n-Butyl-3-methylimidazolium dimethyl phosphate (BMIM DMP) was identified as the most suitable ionic liquid as solvent for the headspace gas chromatographic analysis of solvents with very low vapor p...Read More
Ring inversion, structural stability and vibrational assignments of sulfolane c-C4H8SO2 and 3-sulfolene c-C4H6SO2.
The structural stability of sulfolane (tetrahydrothiophene1,1-dioxide) and 3-sulfolene (dihydrothiophene1,1-dioxide) was investigated by DFT-B3LYP and ab initio MP2 calculations with 6-311+G**) basis ...Read More
Inhibition of acid-catalyzed depolymerization of cellulose with boric acid in non-aqueous acidic media
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This study was undertaken to evaluate sulfolane (tetrahydrothiophene-1, 1-dioxide) attenuation by soil and subsurface materials collected from a sour gas plant site using batch equilibration systems. ...Read More
A review of analytical methods for the determination of sulfolane and alkanolamines in environmental studies.
Sulfolane and alkanolamines are used extensively in the processing of sour natural gases. Over many years of operation, there have been inadvertent leaks of these chemicals to groundwater and wetlands...Read More
Infrared matrix-assisted laser desorption/ionization of polycyclic aromatic hydrocarbons with a sulfolane matrix.
Infrared matrix-assisted laser desorption/ionization (IR-MALDI) of the polyaromatic hydrocarbons (PAHs) anthracene, benzo[a]pyrene, and dibenz[a,h]anthracene was performed using a 10.6-microm CO2 lase...Read More
Nutrient stimulation of sulfolane biodegradation in a contaminated soil from a sour natural gas plant and in a pristine soil.
Natural gas in western Canada can contain up to 35% H2S. The Sulfinol process for sour gas treatment makes use of sulfolane and an amine to remove H2S and other sour components from natural gas. Sulfo...Read More
Ion solvation and association in LiClO4/sulfolane solution: a vibrational spectroscopic and molecular orbital study.
Solvation interaction and ion association in solutions of lithium perchlorate/sulfolane have been studied by using infrared and Raman spectra as a function of concentration of lithium perchlorate. The...Read More
[reaction: see text]. Functionalized diazonium salts for molecular electronic devices are prepared by the reaction of the corresponding anilines with NOBF4 in sulfolane-acetonitrile solvent....Read More
Sulfolane (tetrahydrothiophene-1,1-dioxide) is used in the Sulfinol process for natural gas sweetening. At many sour-gas processing plants spills, landfills and leakage from unlined surface storage po...Read More
Gas chromatographic-mass spectrometric determination of sulfolane in wetland vegetation exposed to sour gas-contaminated groundwater.
Described is a GC-MS method for the determination of the levels of sulfolane (tetrahydrothiophene 1,1-dioxide, C4H8O2S; a water miscible chemical used in the sweetening of sour gas) in wetland vegetat...Read More
A quantitative structure-activity relationship study on some sulfolanes and arylthiomethanes acting as HIV-1 protease inhibitors.
A quantitative structure-activity relationship (QSAR) study on some sulfolanes and arylthiomethanes acting as human immunodeficiency virus-1 (HIV-1) protease inhibitors reveals that in the case of sul...Read More
The efficacy of clay or alcoholate as decontaminants in pigs percutaneously poisoned with 6 LD50 of O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate (VX) and 3 LD50 of 1,2,2-trimethylpropyl me...Read More
A gas-chromatographic assay method for busulfan with sensitivity for test dose therapeutic monitoring.
A gas-chromatographic assay method was developed and validated for determination of busulfan in human plasma for test dose therapeutic drug monitoring. Busulfan and the internal standard (1,6-bis-(met...Read More
Reduction processes in fast atom bombardment mass spectrometry: interdependence of analyte and matrix redox potentials.
The reduction of selected redox indicator dyes during fast atom bombardment mass spectrometry was investigated in several different matrices. Reduction is indicated by the incorporation of one or more...Read More
As a result of radiolysis of sulfolane, that has a radioprotective action, sulfonyl anion-radicals and hydrosulfonyl radicals are produced, subsequent transformations of which lead to complete regener...Read More