产品编号 S128322 | CAS号 69-72-7 | 阿拉丁
Salicylic acid Melting Point Standard
+158 to +160℃
货号 规格 库存 价格 数量
S128322-1g +158 to +160℃ 上海(预计3-7周)


敏感性 对光敏感
溶解性 Soluble in water (1.8 g/L),


产品介绍 Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory and antinociceptive agent and a close structural relative to acetylsalicylic acid (aspirin). Salicylic acid is a ubiquitous plant hormone with many regulatory functions involved in local disease resistance mechanisms and systemic acquired resistance. The antiinflammatory and antinociceptive effects produced by Salicylic acid and its derivatives in animals are due to inhibition of COX-1 and COX-2 (cyclooxygenase) enzyme activity and suppression of prostaglandin biosynthesis. Salicylic acid is also of interest as a starting material for the organic synthesis of more elaborate COX suppressors and other chemical structures.
别名 柳酸; 沙利西酸; 撒酸; 邻羟基苯甲酸; 2-羟基苯甲酸;2-Hydroxybenzoic acid; Bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane
应用 测定铝、硼、铈、铜、铁、铅、锰、汞、银、钛、钨、钒、次亚硫酸盐,硝酸盐和亚硝酸盐。沉淀钍使钍从铈及其他稀土元素中分离出来,分离锆与钛。荧光指示剂;防腐剂;络合指示剂。
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标识符号 GHS05 GHS05, GHS07 GHS07
信号词 Danger
风险声明 (欧洲) R22;R36/37/38;R41
安全声明(欧洲) S26;S37/39
警示性声明 P280,P305+P351+P338
危害码(欧洲) Xn
危害声明 H302,H318
RTECS VO0525000
WGK德国 1
A Guerra, N E Campillo, J A Páez
A neural model based on a numerical molecular representation using CODES program to predict oral absorption of any structure is described. This model predicts both high and low-absorbed compounds with...Read More
Jennifer A Jacobsen, Jessica L Fullagar, Melissa T Miller, Seth M Cohen
Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...Read More
Bram B Baert, Eric E Deconinck, Mireille M Van Gele, Marian M Slodicka, Paul P Stoppie, Samuel S Bodé, Guido G Slegers, Yvan Y Vander Heyden, Jo J Lambert, Johan J Beetens, Bart B De Spiegeleer
Transdermal penetration was studied as a function of selected descriptors in QSPR using CART, boosted CART and MLR models....Read More
Alessio Innocenti, Mika Hilvo, Andrea Scozzafava, Seppo Parkkila, Claudiu T Supuran
We're sorry this abstract is currently not available....Read More
Alessio Innocenti, Daniela Vullo, Andrea Scozzafava, Claudiu T Supuran
Inhibition of 12 mammalian isoforms of the metalloenzyme carbonic anhydrase (CA, EC, CA I-XIV, with a series of phenols was investigated. The inhibition profile by phenols of these CAs was di...Read More
Sevim Beyza Oztürk Sarikaya, Fevzi Topal, Murat Sentürk, Ilhami Gül?in, Claudiu T Supuran
Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurolo...Read More
Hnin Thanda HT Aung, Toshiaki T Nikai, Masatake M Niwa, Yoshiaki Y Takaya
Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxyl...Read More
Amanda Dahl, Margarita Yatskayer, Susana Raab, Christian Oresajo
Hydroquinone (HQ) is the benchmark prescription agent for skin lightening. However, HQ use is recently banned in Europe and in parts of Asia because of potential long-term consequences, including carc...Read More
Francesco F Epifano, Salvatore S Genovese, Silvio S Sosa, Aurelia A Tubaro, Massimo M Curini
The synthesis of ester derivatives of the title acid and their anti-inflammatory activity are reported....Read More
Rafael R Gozalbes, Antonio A Pineda-Lucena
Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a se...Read More
F M Shakirova, M V Bezrukova, R A Yuldashev, R A Fatkhutdinova, A R Murzabaev
We're sorry this abstract is currently not available....Read More
Masaaki Fujikawa, Kazuya Nakao, Ryo Shimizu, Miki Akamatsu
To investigate PAMPA permeability of hydrophobic compounds, we experimentally measured the P"a"p"p"-"p"a"m"p"a of compounds with high hydrophobicity, inclu...Read More
Myrielle M Dupont, Chlo? E CE James, Jacqueline J Chevalier, Jean-Marie JM Pagès
Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and...Read More
Jihye J Kim, Sookjin S Kang, Sungchae S Hong, Soowhan S Yum, Young Mi YM Kim, Yunjin Y Jung
To develop a more potent NFκB inhibitor from salicylic acid which is known to inhibit activity of NFκB, a transcription factor regulating genes involved in immunity, inflammation and tumorigenesis, ...Read More
Wendy R Russell, Lorraine Scobbie, Garry G Duthie, Andrew Chesson
We're sorry this abstract is currently not available....Read More
Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He
We developed an improved Lombardeo's method (J. Med. Chem., 2004) for prediction of VD"s"s in human. With ElogD substituted by logk"I"A"M, together with f"i" &#...Read More
Maciej Ostrowski, Anna Jakubowska
The formation of auxin conjugates is one of the important regulatory mechanisms for modulating IAA action. Several auxin-responsive GH3 genes encode IAA-amide synthetases that are involved in the main...Read More
Carola M CM Wassvik, Anders G AG Holmén, Rieke R Draheim, Per P Artursson, Christel A S CA Bergstr?m
Solubility and solid-state characteristics were determined and multivariate data analysis was used to deduce structural features important for solid-state limited solubility of marketed drugs. Molecul...Read More
Lei Du-Cuny, Zuohe Song, Sylvestor Moses, Garth Powis, Eugene A Mash, Emmanuelle J Meuillet, Shuxing Zhang
Computational modeling continues to play an important role in novel therapeutics discovery and development. In this study, we have investigated the use of in silico approaches to develop inhibitors of...Read More
Kai Zhang, Yuegang Zuo
A GC-MS method was developed for the determination of various flavonoids and phenolic and benzoic acids in human plasma. The procedure involved the extraction of flavonoids and phenolic and benzoic ac...Read More
Michael H Abraham, Adam Ibrahim, William E Acree
Values of in vitro gas to lung partition coefficients, K"l"u"n"g, of VOCs have been collected from the literature. For 44 VOCs, application of the Abraham solvation equation to log...Read More
Gamze G Bora-Tatar, Didem D Dayanga?-Erden, Ayhan S AS Demir, Sevim S Dalkara, Kemal K Yelek?i, Hayat H Erdem-Yurter
In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop ...Read More
Giorgio G Ottaviani, Sophie S Martel, Pierre-Alain PA Carrupt
This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA...Read More
Denis Fourches, Julie C Barnes, Nicola C Day, Paul Bradley, Jane Z Reed, Alexander Tropsha
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...Read More
Peter J McNamara, Rae Ellen Syverson, Kathy Milligan-Myhre, Olga Frolova, Sarah Schroeder, Joshua Kidder, Thanh Hoang, Richard A Proctor
Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...Read More
We're sorry this abstract is currently not available....Read More
Wolfram W Gronwald, Matthias S MS Klein, Raoul R Zeltner, Bernd-Detlef BD Schulze, Stephan W SW Reinhold, Markus M Deutschmann, Ann-Kathrin AK Immervoll, Carsten A CA B?ger, Bernhard B Banas, Kai-Uwe KU Eckardt, Peter J PJ Oefner
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used...Read More
Gregory Kaler, David M Truong, Akash Khandelwal, Megha Nagle, Satish A Eraly, Peter W Swaan, Sanjay K Nigam
Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine thei...Read More
Zhang Shu-Ling, Wang Xing-Fen, Zhang Yan, Liu Jian-Feng, Wu Li-Zhu, Zhang Dong-Mei, Ma Zhi-Ying
WRKY transcription factor proteins play important roles in diverse stress responses. In this study, we first cloned a novel WRKY from our constructed bacteriophage full-length cDNA library for cotton ...Read More
Markus M Fridén, Susanne S Winiwarter, Gunilla G Jerndal, Ola O Bengtsson, Hong H Wan, Ulf U Bredberg, Margareta M Hammarlund-Udenaes, Madeleine M Antonsson
New experimental methodologies were applied to measure the unbound brain-to-plasma concentration ratio (K(p,uu,brain)) and the unbound CSF-to-plasma concentration ratio (K(p,uu,CSF)) in rats for 43 st...Read More
Albert Sánchez, Enrique Pedroso, Anna Grandas
Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular ol...Read More
Chao-Bin CB Xue, Li L Zhang, Wan-Chun WC Luo, Xian-Ye XY Xie, Lin L Jiang, Ting T Xiao
Inhibitions of three classes compounds against phenoloxidase were investigated, and 3D-QSAR was performed. The interactions between compounds N18 and phenoloxidase active site were also studied using ...Read More
Roger Fuoco, Patrizia Bogani, Gabriele Capodaglio, Massimo Del Bubba, Ornella Abollino, Stefania Giannarelli, Maria Michela Spiriti, Beatrice Muscatello, Saer Doumett, Clara Turetta, Roberta Zangrando, Vincenzo Zelano, Marcello Buiatti
Recently our findings have shown that the integration of the gene coding for the rat gluco-corticoid receptor (GR receptor) in Nicotiana langsdorffii plants induced morphophysiological effects in tran...Read More
Daisuke Igarashi, Gerit Bethke, Yuan Xu, Kenichi Tsuda, Jane Glazebrook, Fumiaki Katagiri
Programmed cell death (PCD) is a crucial process for plant innate immunity and development. In plant innate immunity, PCD is believed to prevent the spread of pathogens from the infection site. Althou...Read More
Loretta L Aureli, Gabriele G Cruciani, Maria Candida MC Cesta, Roberto R Anacardio, Lucio L De Simone, Alessio A Moriconi
A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities. These CXCL8 inhibitors are derivatives of phe...Read More
David D Buttar, Nicola N Colclough, Stefan S Gerhardt, Philip A PA MacFaul, Scott D SD Phillips, Alleyn A Plowright, Paul P Whittamore, Kin K Tam, Klaus K Maskos, Stefan S Steinbacher, Holger H Steuber
The displacement of probes that bind selectively to subdomains IIA or IIIA on human serum albumin (HSA) by competing compounds has been followed using fluorescence spectroscopy, and has therefore been...Read More
Naohiko Kodo, Toshiro Matsuda, Syuichi Doi, Hiroshi Munakata
Yeast cells can extrude intracellular drugs through membrane-associated efflux pumps, such as ATP-binding cassette (ABC) transporters and members of the major facilitator superfamily. Gene expression ...Read More
Yun Chen, Guo-Kai Wang, Can Wu, Min-Jian Qin
To determine the chemical constituents of Gentiana rhodantha.To isolate the constituents, column chromatography over silica gel, MCI, Sephadex LH-20 and C18 reverse-phased silica gel were used. Spectr...Read More
Loretta L Lazzarato, Monica M Donnola, Barbara B Rolando, Elisabetta E Marini, Clara C Cena, Gabriella G Coruzzi, Elena E Guaita, Giuseppina G Morini, Roberta R Fruttero, Alberto A Gasco, Stefano S Biondi, Ennio E Ongini
A new class of products in which the phenol group of salicylic acid is linked to alkanoyl moieties bearing nitrooxy functions has been synthesized and studied for their polyvalent actions. The product...Read More
Suja Shrestha, Bharat Raj Bhattarai, Bhooshan Kafle, Keun-Hyeung Lee, Hyeongjin Cho
PTP1B inhibitor with hypoglycemic activity....Read More
Suneela S Dhaneshwar, Neha Gairola, Mini Kandpal, Gaurav Vadnerkar, Lokesh Bhatt, Badal Rathi, SS Kadam
Colon-specific mutual azo prodrugs of 5-aminosalicylic acid with essential amino acids were synthesized for the management of inflammatory bowel disease. The structures were confirmed by elemental and...Read More
Esra Bayram, Murat Senturk, O Irfan Kufrevioglu, Claudiu T Supuran
We're sorry this abstract is currently not available....Read More
M M Rutner, J J Fitzek, H H Jahnel-Kracht, J J Otto, W W Krause
Two clinical studies were carried out to investigate the efficacy and safety as well as the local and systemic availability of a hydroxyethylsalicyclate gel. A double blind, multicenter trial, involvi...Read More
Fuqiang Xing, Zhe Li, Aizhen Sun, Da Xing
We report a novel regulatory mechanism by which reactive oxygen species (ROS) regulate fumonisin B1 (FB1)-induced cell death. We found that FB1 induction of light-dependent ROS production promoted the...Read More
Babasaheb P Bandgar, Sachin A Patil, Rajesh N Gacche, Balaji L Korbad, Balwant S Hote, Santosh N Kinkar, Shivkumar S Jalde
A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin ...Read More
Loretta L Lazzarato, Clara C Cena, Barbara B Rolando, Elisabetta E Marini, Marco Lucio ML Lolli, Stefano S Guglielmo, Elena E Guaita, Giuseppina G Morini, Gabriella G Coruzzi, Roberta R Fruttero, Alberto A Gasco
A new group of derivatives of salicylic acid containing NO-donor furoxans, and the related des-NO-furazans, were synthesized and evaluated as new aspirin-like molecules. Their stability was assessed i...Read More
Thorsten E TE Fisher, Boyoung B Kim, Donnette D DD Staas, Terry A TA Lyle, Steven D SD Young, Joseph P JP Vacca, Matthew M MM Zrada, Daria J DJ Hazuda, Peter J PJ Felock, William A WA Schleif, Lori J LJ Gabryelski, M Reza MR Anari, Christopher J CJ Kochan
A series of potent novel 8-hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and v...Read More
Esben Lynge Nordentoft, Frans Boch Waldorf
Viral warts are common skin lesions caused by human papilloma virus. This article describes the pathogenesis, symptoms and treatment methods of cutaneous warts. The majority resolves spontaneously and...Read More
Tsuyoshi Saitoh, Eriko Suzuki, Arisa Takasugi, Rika Obata, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama
Dehydroxymethylepoxyquinomicin (DHMEQ, 1) is a novel nuclear factor-@kB (NF-@kB) inhibitor that inhibits DNA binding of NF-@kB components including p65. To inspect its biological activity of 1, we syn...Read More
Bharat Raj Bhattarai, Jeong-Hyeon Ko, Suja Shrestha, Bhooshan Kafle, Heeyeong Cho, Ju-Hee Kang, Hyeongjin Cho
In a previous study, protein tyrosine phosphatase 1B (PTP1B) inhibitors, SA18 and SA32, exhibited anti-obesity effects in a mouse model by suppressing weight gain and improving blood parameters, inclu...Read More
Melinda Roberts, Saijun Tang, Anna Stallmann, Jeffery L Dangl, Vera Bonardi
Plants react to pathogen attack via recognition of, and response to, pathogen-specific molecules at the cell surface and inside the cell. Pathogen effectors (virulence factors) are monitored by intrac...Read More
Maren Friebe, Stephan Schumacher, Jessica Stahl, Manfred Kietzmann
This study investigated synovial concentrations of acetylsalicylic acid (ASA) and its metabolite salicylic acid (SA) in the equine fetlock joint following systemic administration of ASA. Salicylates w...Read More
Liyu Shi, Jianfeng Weng, Changlin Liu, Xinyuan Song, Hongqin Miao, Zhuanfang Hao, Chuanxiao Xie, Mingshun Li, Degui Zhang, Li Bai, Guangtang Pan, Xinhai Li, Shihuang Zhang
Maize rough dwarf disease (MRDD, a viral disease) results in significant grain yield losses, while genetic basis of which is largely unknown. Based on comparative genomics, eukaryotic translation init...Read More
Abdul Latif Khan, Muhammad Waqas, Muhammad Hamayun, Ahmed Al-Harrasi, Ahmed Al-Rawahi, In-Jung Lee
Water-deficiency adversely affects crop growth by generating reactive oxygen species (ROS) at cellular level. To mitigate such stressful events, it was aimed to investigate the co-synergism of exogeno...Read More
Ronald L Moy, Corey Levenson, Jeffrey J So, James A Rock
A proprietary topical blend of salicylic acid and highly purified sandalwood oil from Australia was used in this open-label study in adolescents and adults with mild to moderate facial acne.The invest...Read More
Alan R Shalita, Whitney P Bowe
We're sorry this abstract is currently not available....Read More
Lawrence Green, Leon H Kircik, Jennifer Gwazdauskas
Acne vulgaris is a common dermatologic disease that most frequently affects adolescents and young adults. Over-the-counter (OTC) acne treatment regimens are increasingly being used by individuals with...Read More
Ramesh Kekuda, Palanikumar Manoharan, Walter Baseler, Uma Sundaram
Short chain fatty acids (SCFA) are absorbed by carrier mediated uptake in the small intestine by pH-dependent SCFA/HCO3 (-) exchangers on the apical membrane of epithelial cells. Conventional assumpti...Read More
Hongying Cui, Yucheng Sun, Jianwei Su, Chuanyou Li, Feng Ge
The effect of previous infestation (preconditioning) by the whitefly Bemisia tabaci (Gennadius) biotype B on the population fitness of subsequent infestations that fed on three isogenic tomato genotyp...Read More
Clare L Casteel, Lauren M Segal, Olivia K Niziolek, May R Berenbaum, Evan H Delucia
Concentrations of carbon dioxide (CO(2)) are increasing in the atmosphere, affecting soybean (Glycine max L.) phytohormone signaling and herbivore resistance. Whether the impact of elevated CO(2) on p...Read More
Limor Poraty-Gavra, Philip Zimmermann, Sabine Haigis, Pawel Bednarek, Ora Hazak, Oksana Rogovoy Stelmakh, Einat Sadot, Paul Schulze-Lefert, Wilhelm Gruissem, Shaul Yalovsky
How plants coordinate developmental processes and environmental stress responses is a pressing question. Here, we show that Arabidopsis (Arabidopsis thaliana) Rho of Plants6 (AtROP6) integrates develo...Read More
Yunlong Du, Ricardo Tejos, Martina Beck, Ellie Himschoot, Hongjiang Li, Silke Robatzek, Steffen Vanneste, Jirí Friml
Removal of cargos from the cell surface via endocytosis is an efficient mechanism to regulate activities of plasma membrane (PM)-resident proteins, such as receptors or transporters. Salicylic acid (S...Read More
Shifeng Cao, Ting Liu, Yueming Jiang, Shenggen He, Dion K Harrison, Daryl C Joyce
The effect of elicitors associated with host defence on betacyanin accumulation in Amaranthus mangostanus seedlings was investigated. Under the conditions of the experiments, betacyanin accumulation w...Read More
Sreeman K Mamidyala, Soumya Ramu, Johnny X Huang, Avril A B Robertson, Matthew A Cooper
Anacardic acid derivatives exhibit a broad range of biological activities. In this report, an efficient method for the synthesis of anacardic acid derivatives was explored, and a small set of salicyli...Read More
Zheng Qing Fu, Xinnian Dong
Systemic acquired resistance (SAR) is an induced immune mechanism in plants. Unlike vertebrate adaptive immunity, SAR is broad spectrum, with no specificity to the initial infection. An avirulent path...Read More
Dorothea Ellinger, Marcel Naumann, Christian Falter, Claudia Zwikowics, Torsten Jamrow, Chithra Manisseri, Shauna C Somerville, Christian A Voigt
A common response by plants to fungal attack is deposition of callose, a (1,3)-β-glucan polymer, in the form of cell wall thickenings called papillae, at site of wall penetration. While it has been g...Read More
Leon H Kircik, Jennifer Gwazdauskas, Victoria Butners, Joseph Eastern, Lawrence J Green
Benzoyl peroxide (BPO) is a widely used over-the-counter (OTC) topical acne treatment often used in combination with salicylic acid (SA) to achieve better comedone control than that achieved with BPO ...Read More
Jinyoung Kwak, Sang-Yup Lee
Photoluminescent spherical nanostructures were prepared through the self-assembly of a tyrosine-containing bolaamphiphilic molecule, and their antenna effect was examined. The photoluminescent spheric...Read More
G Wolf
We're sorry this abstract is currently not available....Read More
Yuhong Li, Weidong Gao, Kongshuang Zhao, Gang Yang, Zhonghe Zhu, Rongjing Cui
The adsorption process of salicylic acid (SA) onto chitosan membrane is monitored in real time by the dielectric relaxation spectroscopy (DRS) method. A unique dielectric relaxation, which is related ...Read More
M M MM Vila, M M Tubino, G G de Oliveira Neto
A flow injection (FI) enzymatic system, based on the use of immobilized salicylate hydroxylase in glass beads, was developed for the determination of salicylate. Salicylate hydroxylase and nicotinamid...Read More
E Hazouard, M Grimbert, A P Jonville-Berra, M C De Toffol, A Legras
We report a case of salicylism caused by association of acetylsalicylic acid (ASA) and acetazolamide. A 50-year-old woman without chronic renal insufficiency, was admitted for confusion, cerebellar at...Read More
P P Singh, M M Anliker, G A GA Smith, D D Zavortink, H I HI Maibach
The potential of transdermal iontophoresis to facilitate drug delivery was evaluated by studying the transport kinetics of model compounds salicylate (anion), phenylethylamine (cation), mannitol (pola...Read More
S G SG Owen, H W HW Francis, M S MS Roberts
1. Five rheumatoid patients with a knee joint effusion participated in the study. An aqueous solution (0.1 to 0.2 ml) containing paracetamol, salicylate, diclofenac and [125I]-albumin was injected int...Read More
A A Kunkel, H H W?tzig
Capillary electrophoresis (CE) is often regarded as a separation technique of choice because of its high selectivity and its cost advantages compared to LC.RSD% of 0.5% have become standard for qualit...Read More
A Quaranta, P Portalatini, M Camporeale, V Sallustio
The aim of this study was to evaluate, in young volunteer subjects, the effects of salicylates on evoked otoacoustic emissions (EOAEs), which presumably reflect an active mechanical process in the coc...Read More
E Benfeldt, J Serup, T Menn??
Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given ...Read More
Azaroual, M M Imbenotte, B B Cartigny, M M Lhermitte, G G Vermeersch
By comparison of urine 1H NMR spectrum from a healthy person with those from poisoned patient, we have displayed one or several signals related to intoxication. In complement, various 1H and 13C NMR s...Read More
S Zaugg, X Zhang, J Sweedler, W Thormann
Acetylsalicylic acid (Aspirin) is rapidly metabolized to salicylic acid (salicylate) and other compounds, including gentisic acid and salicyluric acid. Monitoring of salicylate and its metabolites is ...Read More
K K Alanko, S S Stubb, O P OP Salo, S S Reitamo
The histamine concentration was measured from suction blister fluid obtained from normal and lesional skin of 8 patients with fixed drug eruption (FDE) caused by phenazone salicylate and from that of ...Read More
A Z AZ Khan, L L Aarons
A sequential approach is presented to the problem of determining the minimum number of blood samples needed to calculate the plasma to saliva concentration ratio to a required precision. The method wa...Read More
O S Goussis, T J Theodoropoulos
Earlier studies have shown that drugs such as dilantin inhibit T4 binding by thyroid hormone binding globulin (TBG) and cause a displacement of T4 from TBG to prealbumin with no change in the albumin-...Read More
S A SA Kocoshis, C T CT Wong
Previous studies by us suggested that luminally administered sodium salicylate blocks dihydroxy-bile acid-induced colonic secretion in the rat. In the present study, an in vivo rat cecal loop techniqu...Read More
Themba T TT Ndovi, Leena L Choi, Brian B Caffo, Teresa T Parsons, Sharon S Baker, Ming M Zhao, Charles C Rohde, Craig W CW Hendrix
Background: The male genital tract is a complex collection of anatomically and biochemically distinct compartments that contribute to the ejaculate. Understanding the pharmacokinetics in these compart...Read More
J E JE Baggott, S L SL Morgan, T T Ha, W H WH Vaughn, R J RJ Hine
Many non-steroidal anti-inflammatory drugs (NSAIDs) (including sulphasalazine, sulindac, indomethacin, naproxen, salicylic acid, ibuprofen, piroxicam and mefenamic acid) were found to be competitive i...Read More
F P Schmook, J G Meingassner, A Billich
For the study of in-vitro skin penetration of candidate drugs, excised animal skin is frequently used as a replacement for human skin. Reconstructed human skin or epidermis equivalents have been propo...Read More
Anil A Kumar, Balasubramanian B Narasimhan, Devinder D Kumar
We're sorry this abstract is currently not available....Read More
Joshua S Mylne, Conan K Wang, Nicole L van der Weerden, David J Craik
Cyclotides are small cysteine-rich plant peptides similar in size and processing to the defensins. Long-term growth of the Rubiaceae family plant Oldenlandia affinis under different conditions reveals...Read More