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Urine has long been a "favored" biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically compl...Read More
This work presents insight into the self-photorechargeability of WO(3) , whereby the intercalation of positive alkali cations is accompanied by the simultaneous storage of photo-excited electrons. The...Read More
Our aim was to determine changes in free amino acid (FAA) and dipeptide (DP) concentrations in probable Alzheimer's disease (pAD) subjects compared with control (CT) subjects using liquid chromat...Read More
Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid.
Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overla...Read More
The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.
There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation tha...Read More
Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC), pyruvate-dehydrogenase complex (P...Read More
Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.
To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measure...Read More
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels o...Read More
To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino ac...Read More
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were...Read More
Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease.
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid ...Read More
Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.
An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons. It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylc...Read More
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several o...Read More
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supp...Read More
Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphoc...Read More
Although some studies suggested a link between exposure to trace elements and development of multiple sclerosis (MS), clear information on their role in the aetiology of MS is still lacking. In this s...Read More
It is well known that brain and nervous system cells are prone to oxidative damage because of their relatively low content of antioxidants, especially enzymatic ones, and of the high levels of both me...Read More
Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction.
Several findings suggest lower levels of serum uric acid in multiple sclerosis (MS) patients. The aim of this study is to investigate relationships of uric acid serum levels in relapse-remitting (RR) ...Read More
Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine.
Recent studies suggest that NO and its reactive derivative peroxynitrite are implicated in the pathogenesis of multiple sclerosis (MS). Patients dying with MS demonstrate increased astrocytic inducibl...Read More
Twenty-six metals and the oxidative status in 71 patients affected by Parkinson's disease and 44 healthy individuals were compared in order to identify potential biomarkers of the disease. In the...Read More
Evidence from clinical and experimental studies supports the hypothesis of free radical-mediated damage of dopaminergic neurons in the pathology of Parkin's disease (PD). The present study was un...Read More
Dopamine neurons in the substantia nigra of human brain are selectively vulnerable and the number decline by aging at 5-10% per decade. Enzymatic and non-enzymatic oxidation of dopamine generates reac...Read More
We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and it...Read More
Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease.
In order to investigate the possible role of oxidative RNA damage in the pathogenesis of Parkinson's disease (PD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) wer...Read More
Liquid chromatography with amperometric detection at a nano crystalline Ce-doped lead dioxide film modified electrode for determination of (R)-Salsolinol, (R)-N-methylsalsolinol and monoamine neurotransmitters in Parkinsonian patients' cerebrospinal
The fabrication and application of a novel electrochemical detector (ED) with nano crystalline Ce-doped lead dioxide film chemically modified electrode (CME) for liquid chromatography (LC) were descri...Read More
1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.
1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level ...Read More
The formation of 3-hydroxy-4-methoxyphenylalanine and 3-hydroxy-4-methoxyphenethylamine in plasma during L-DOPA therapy in patients with Parkinson's disease.
We're sorry this abstract is currently not available....Read More
Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease (PD), CSF HVA is normal in mildly af...Read More
Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis.
Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases....Read More
Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels.
To determine if ventricular cerebrospinal fluid (vCSF) alpha-tocopherol levels in Parkinson's disease (PD) patients can be increased by oral alpha-tocopherol supplementation and whether vCSF leve...Read More
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed t...Read More
Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid.
Increased plasma total homocysteine (tHcy) is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained....Read More
Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid.
Multiple sclerosis (MS), an inflammatory disease of the central nervous system, manifests itself in numerous forms and stages. A number of brain metabolic alterations have been reported for MS patient...Read More
Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission.
Magnetic resonance imaging of multiple sclerosis (MS) patients often shows active inflammatory lesions despite clinical remission. No immunological marker of disease activity has been identified in th...Read More
Size-controlled PtRu nanoparticles embedded in WO3 were prepared by simultaneous multigun sputtering on pure targets of Pt, Ru, and WO3. The mean diameter of the PtRu nanoparticles, as confirmed by hi...Read More
182Hf-182W age dating of a 26Al-poor inclusion and implications for the origin of short-lived radioisotopes in the early Solar System.
Refractory inclusions [calcium-aluminum-rich inclusions, (CAIs)] represent the oldest Solar System solids and provide information regarding the formation of the Sun and its protoplanetary disk. CAIs c...Read More
Trace element reference values in tissues from inhabitants of the European Community. II. Examples of strategy adopted and trace element analysis of blood, lymph nodes and cerebrospinal fluid of Italian subjects.
The EURO TERVIHT (Trace Element Reference Values in Human Tissues), recently initiated, aims to establish and compare trace metal reference values in inhabitants from the different EC countries. The p...Read More
Novel hetero-layered materials with tunable direct band gaps by sandwiching different metal disulfides and diselenides.
Although bulk hexagonal phases of layered semiconducting transition metal dichalcogenides (STMD) such as MoS2, WS2, WSe2 and MoSe2 exhibit indirect band gaps, a mono-layer of STMD possesses a direct b...Read More
Ni-W alloy coatings were prepared by electrodeposition technique with citric acid as a complexing agent. The influence of the main technical parameters on W content in the Ni-W alloy coatings were inv...Read More
On the application of nanostructured electrodes prepared by Ti/TiO2/WO3 "template": a case study of removing toxicity of indigo using visible irradiation.
New assays with HepG2 cells indicate that Indigo Carmine (IC), a dye that is widely used as additive in many food and pharmaceutical industries exhibited cytotoxic effects. This work describes the dev...Read More
Synthesis and structural investigations of gel metal oxide composites WO?-ZrO?, WO?-TiO?, WO?-ZrO?-SiO?, and their evaluation as materials for the preparation of 1??W/1??Re generator.
The gel composites of WO3-ZrO2, WO3-TiO2, WO3-ZrO2-SiO2 at different molar ratios of oxides were synthesized. The elution profiles of the generator columns packed with gel samples activated at the Pol...Read More
For fabricating the crystal of Rb(x)WO3, the solvothermal process was performed using a mixed medium of water and ethanol as solvent. It has been found that the morphological evolutions of samples wer...Read More
Monte Carlo simulation techniques using a Monte Carlo N-Particle code (MCNP5) analyzed six Source Production & Equipment Co., Inc., Se industrial radiography sources to determine an appropriate ai...Read More
A photometric high-throughput method for identification of electrochemically active bacteria using a WO3 nanocluster probe.
Electrochemically active bacteria (EAB) are ubiquitous in environment and have important application in the fields of biogeochemistry, environment, microbiology and bioenergy. However, rapid and sensi...Read More
Synthesis, crystal structure, mass spectrometry, electrochemistry and magnetism of a Mn(III)-substituted trilacunary Keggin tungstosilicate.
A rare example of a "monomeric" triple transition-metal substituted Keggin anion has been synthesized and characterized by various methods including X-ray crystallography, ESI and MALDI mass...Read More
Assessment of interatomic potentials for atomistic analysis of static and dynamic properties of screw dislocations in W.
Screw dislocations in bcc metals display non-planar cores at zero temperature which result in high lattice friction and thermally-activated strain rate behavior. In bcc W, electronic structure molecul...Read More
A new coupling of ionic liquid based-single drop microextraction with tungsten coil electrothermal atomic absorption spectrometry.
In this work, an improved method of ionic liquid based-single drop microextraction (IL-SDME) preconcentration was firstly coupled with tungsten coil electrothermal atomic absorption spectrometry (W-co...Read More
Comparison between tungsten and steel polypectomy snares: evaluation of depth of colonic thermal wall injury in a pig model.
Background and study aims: Thermal injury of the colonic wall during polypectomy may induce complications such as bleeding and perforation. To date, the role of the snare material in these injuries ha...Read More
Ordered mesoporous tungsten suboxide counter electrode for highly efficient iodine-free electrolyte-based dye-sensitized solar cells.
A disulfide/thiolate (T(2) /T(-) ) redox-couple electrolyte, which is a promising iodine-free electrolyte owing to its transparent and noncorrosive properties, requires alternative counter-electrode m...Read More
Electrochemical impedance spectroscopic technique with a functionalized microwire sensor for rapid detection of foodborne pathogens.
In this study, a label-free biosensor based on electrochemical impedance measurement followed by dielectrophoretic force and antibody-antigen interaction was developed for detection and quantification...Read More
Atomistic computer simulations were performed to study the influence of radiation-induced damage on grain boundary (GB) sliding processes in bcc tungsten (W), the divertor material in the ITER tokamak...Read More
The catheter-based intravascular photoacoustic (IVPA) imaging for diagnosing atherosclerosis, which can provide optical absorption contrast of the arterial wall besides acoustic scattering contrast fr...Read More
Formation energy and photoelectrochemical properties of BiVO4 after doping at Bi3+ or V5+ sites with higher valence metal ions.
Photoelectrochemical water splitting is an attractive method to produce H(2) fuel from solar energy and water. Ion doping with higher valence states was used widely to enhance the photocurrent of an n...Read More
First-principle calculations are employed to show that the magnetic structure of small atomic clusters of Co, formed on a crystalline W(110) surface and containing 3-12 atoms, strongly deviates from t...Read More
A novel photoelectrochemical sensor based on PPIX-functionalized WO3-rGO nanohybrid-decorated ITO electrode for detecting cysteine.
A universal photoelectrochemical (PEC) sensing platform was fabricated based on the composition of protoporphyrin IX (PPIX), tungsten trioxide (WO3) and reduced graphene oxide (rGO) on indium tin oxid...Read More
The long-term performance of chronic microelectrode array implants for neural ensemble recording is affected by temporal degradation in signal quality due to several factors including structural chang...Read More
[The possibility of using inorganic fillers and matrix polymers in materials for radiation protection].
We're sorry this abstract is currently not available....Read More
The recent emergence of micro-devices for vaccine delivery into upper layers of the skin holds potential for increased immune responses using physical means to target abundant immune cell populations....Read More
Variable Pathways for Oxygen Atom Insertion into Metal-Carbon Bonds: The Case of Cp*W(O)(2)(CH(2)SiMe(3)).
Cp*W(O)(2)(CH(2)SiMe(3)) (1) (Cp* = η(5)-pentamethylcyclopentadienyl) reacts with oxygen atom donors (e.g., H(2)O(2), PhIO, IO(4)(-)) in THF/water to produce TMSCH(2)OH (TMS = trimethylsilyl). For th...Read More
Ultrafine tungsten nanocrystals (average size of 3 nm) with a metastable phase (beta-tungsten with A15 structure, β-W) have been prepared by laser ablation of tungsten in liquid nitrogen. The as-prep...Read More
Geometrical confinement effect in exfoliated sheets of layered materials leads to significant evolution of energy dispersion in mono- to few-layer thickness regime. Molybdenum disulfide (MoS(2)) was r...Read More
Damage investigation on tungsten and diamond diffractive optics at a hard x-ray free-electron laser.
Focusing hard x-ray free-electron laser radiation with extremely high fluence sets stringent demands on the x-ray optics. Any material placed in an intense x-ray beam is at risk of being damaged. Ther...Read More
Ultrathin PEGylated W18O49 nanowires as a new 980 nm-laser-driven photothermal agent for efficient ablation of cancer cells in vivo.
A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in ...Read More
Effects of Tungsten and Titanium Oxide Nanoparticles on the Diazotrophic Growth and Metals Acquisition by Azotobacter vinelandii under Molybdenum Limiting Condition.
The acquisition of essential metals, such as the metal cofactors (molybdenum (Mo) and iron (Fe)) of the nitrogenase, the enzyme responsible for the reduction of dinitrogen (N(2)) to ammonium, is criti...Read More
Rapid additive manufacturing of MR compatible multipinhole collimators with selective laser melting of tungsten powder.
Purpose: The construction of complex collimators with a high number of oblique pinholes is very labor intensive, expensive or is sometimes impossible with the current available techniques (drilling, m...Read More
Oral administration of sodium tungstate improves cardiac performance in streptozotocin-induced diabetic rats.
Normalization of hyperglycemia and hyperlipidemia is an important objective in preventing diabetes-induced cardiac dysfunction. Our study investigated the effects of sodium tungstate on cardiac perfor...Read More
Exposure to metals may promote atherosclerosis. Blood cadmium and lead were associated with peripheral arterial disease (PAD) in the 1999-2000 National Health and Nutrition Examination Survey (NHANES)...Read More
Since its discovery, tungsten, a transition element of Group VIb of the Periodic Table of Elements, and its compounds have been considered environmentally benign. Its presence in biological and drinki...Read More
Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet
Hyperlipidemia enhances xanthine oxidase (XO) activity. XO is an important source of reactive oxygen species (ROS). Since ROS are thought to promote atherosclerosis, we hypothesized that XO is involve...Read More
Dissolution of tungsten coils does not produce systemic toxicity, but leads to elevated levels of tungsten in the serum and recanalization of the previously occluded vessel.
To evaluate the failure of mechanically detachable spirals produced from tungsten (MDS, Balt, Montmorency, France) and the toxicity of elevated levels of tungsten in the serum subsequent to their impl...Read More