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土木香内酯

6篇引用文献
  • CAS编号: 546-43-0
  • 分子式: C15H20O2
  • 分子量: 232.32
  • PubChem编号: 72724
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货号 (SKU) 包装规格 是否现货 价格 数量
A114070-10mg
 10mg 现货 Stock Image
A114070-20mg
 20mg 现货 Stock Image
A114070-50mg
 50mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
JAK/STAT Signaling (505) STAT (139) Stem Cell/Wnt (1018) TGF-beta/Smad (304)
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基本描述

英文别名 (3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3,3a,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(5H)-one | Q21099633 | DTXSID90877864 | KBio3_002395 | D-Catechin | Stanzamine | 2-Amino-4,5-methylenehex-5-enoic acid | NCGC00178225-01 | Spectrum4_001772 | NSC 9
规格或纯度 分析标准品, ≥97%(HPLC)
英文名称 Alantolactone
应用 Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells
储存温度 避光,-20°C储存
运输条件 超低温冰袋运输
产品介绍

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells

AI解读

关联靶点（人）

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PARP1 Tclin Poly [ADP-ribose] polymerase-1 (6206 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A498 (42825 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 活性数据)
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CAKI-1 (44928 活性数据)
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CCRF-CEM (65223 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 205 (50209 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-1080 (3966 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM12 (47707 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M14 (47487 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
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MOLT-4 (49676 活性数据)
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OVCAR-3 (48710 活性数据)
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OVCAR-4 (44535 活性数据)
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OVCAR-5 (45555 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 393 (41971 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-295 (48000 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SN12C (47755 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-19 (46794 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TK-10 (45540 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-251 (51189 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-257 (46019 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-62 (47335 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UO-31 (46270 活性数据)
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786-0 (47912 活性数据)
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A549 (127892 活性数据)
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NCI/ADR-RES (33767 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T47D (39041 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EKVX (44102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H322M (45589 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC 2998 (41480 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HOP-92 (41141 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hs-578T (29457 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
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SF-268 (49410 活性数据)
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HUVEC (11049 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IGROV-1 (47897 活性数据)
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关联靶点（其它种属）

murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase (389 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P388 (20296 活性数据)
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RAW264.7 (28094 活性数据)
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rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aedes atropalpus (23 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MYB Transcriptional activator Myb (118 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name (3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-5,6,7,8,9,9a-hexahydro-3aH-benzo[f][1]benzofuran-2-one
INCHI InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1
InChi Key PXOYOCNNSUAQNS-AGNJHWRGSA-N
Canonical SMILES CC1CCCC2(C1=CC3C(C2)OC(=O)C3=C)C
Isomeric SMILES C[C@H]1CCC[C@]2(C1=C[C@H]3[C@@H](C2)OC(=O)C3=C)C
WGK Germany 3
PubChem CID 72724
分子量 232.32

化学和物理性质

密度 1.08
敏感性 对光线敏感
分子量 232.320 g/mol
XLogP3 3.700
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 232.146 Da
单同位素质量Monoisotopic Mass 232.146 Da
拓扑极表面积Topological Polar Surface Area 26.300 Ų
重原子数Heavy Atom Count 17
形式电荷Formal Charge 0
复杂度Complexity 421.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 4
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H317: 可能引起皮肤过敏反应
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P501: 将内容物/容器处理到。。。

P272: 被污染的工作服不允许离开工作场所

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
WGK Germany 3

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找到4个结果

批号(Lot Number) 证书类型 日期 货号
A2203210 分析证书 23-10-08 A114070
G2329055 分析证书 23-06-29 A114070
G2329064 分析证书 23-06-29 A114070
K1208029 分析证书 22-05-12 A114070

可替换产品

  1. 异土木香内酯
    异土木香内酯
    • 10mM in DMSO

    ¥720.90

  2. 去氢木香内酯
    去氢木香内酯
    • 10mM in DMSO

    ¥205.90

  3. 异土木香内酯
    异土木香内酯

    ¥236.90

  4. 土木香内酯
    土木香内酯
    • 10mM in DMSO

    ¥208.90

  5. 异土木香内酯
    异土木香内酯
    • ≥98%

    ¥99.90

  6. 去氢木香内酯
    去氢木香内酯

    ¥269.90

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Zhang Yafei, Yang Bingqian, Tu Chengwei, Ping Yifan, Chen Shuhong, Wu Tong, Zhao Zheyu, Mao Yixin, Yang Zhan, Cao Zelin, Li Jianmin, Huang Kate, Ding Xi, Wu Gang, Zou Peng, Deng Zhennan, Sun Xiaoyu.  (2023)  Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells.  Journal of Translational Medicine,  21  (1): (1-17).  [PMID:37198593] [10.1186/s12967-023-04188-2]
2. Qiburi Qiburi, Tsogzolmaa Ganbold, Aoqier Aoqier, Dezhi Yang, Zhiyu Su, Mingming Bao, Meng He, Saren Gaowa, Temuqile Temuqile, Huricha Baigude.  (2022)  Analysis and identification of key anti-inflammatory molecules in Eerdun Wurile and exploration of their mechanism of action in microglia.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1211  (123458).  [PMID:36183605] [10.1016/j.jchromb.2022.123458]
3. Qiburi Qiburi, Temuqile Temuqile, Huricha Baigude.  (2021)  Synergistic Regulation of Microglia Gene Expression by Natural Molecules in Herbal Medicine.  Evidence-based Complementary and Alternative Medicine,  2021  (9920364).  [PMID:34457033] [10.1155/2021/9920364]
4. Bao Shihui, Zheng Hailun, Ye Jinyao, Huang Huirong, Zhou Bin, Yao Qing, Lin Guangyong, Zhang Hailin, Kou Longfa, Chen Ruijie.  (2021)  Dual Targeting EGFR and STAT3 With Erlotinib and Alantolactone Co-Loaded PLGA Nanoparticles for Pancreatic Cancer Treatment.  Frontiers in Pharmacology,  12  (138).  [PMID:33815107] [10.3389/fphar.2021.625084]
5. Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou.  (2019)  Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.  International Journal of Biological Sciences,  15  (8): ( 1676–1684).  [PMID:31360110] [10.7150/ijbs.35265]
6. Yao Yao, Xia Dandan, Bian Yueping, Sun Yueyue, Zhu Feng, Pan Bin, Niu Mingshan, Zhao Kai, Wu Qingyun, Qiao Jianlin, Fu Chunling, Li Zhenyu, Xu Kailin.  (2015)  Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance.  APOPTOSIS,  20  (8): (1122-1133).  [PMID:26033479] [10.1007/s10495-015-1140-2]

参考文献

1. Zhang Yafei, Yang Bingqian, Tu Chengwei, Ping Yifan, Chen Shuhong, Wu Tong, Zhao Zheyu, Mao Yixin, Yang Zhan, Cao Zelin, Li Jianmin, Huang Kate, Ding Xi, Wu Gang, Zou Peng, Deng Zhennan, Sun Xiaoyu.  (2023)  Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells.  Journal of Translational Medicine,  21  (1): (1-17).  [PMID:37198593] [10.1186/s12967-023-04188-2]
2. Qiburi Qiburi, Tsogzolmaa Ganbold, Aoqier Aoqier, Dezhi Yang, Zhiyu Su, Mingming Bao, Meng He, Saren Gaowa, Temuqile Temuqile, Huricha Baigude.  (2022)  Analysis and identification of key anti-inflammatory molecules in Eerdun Wurile and exploration of their mechanism of action in microglia.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1211  (123458).  [PMID:36183605] [10.1016/j.jchromb.2022.123458]
3. Qiburi Qiburi, Temuqile Temuqile, Huricha Baigude.  (2021)  Synergistic Regulation of Microglia Gene Expression by Natural Molecules in Herbal Medicine.  Evidence-based Complementary and Alternative Medicine,  2021  (9920364).  [PMID:34457033] [10.1155/2021/9920364]
4. Bao Shihui, Zheng Hailun, Ye Jinyao, Huang Huirong, Zhou Bin, Yao Qing, Lin Guangyong, Zhang Hailin, Kou Longfa, Chen Ruijie.  (2021)  Dual Targeting EGFR and STAT3 With Erlotinib and Alantolactone Co-Loaded PLGA Nanoparticles for Pancreatic Cancer Treatment.  Frontiers in Pharmacology,  12  (138).  [PMID:33815107] [10.3389/fphar.2021.625084]
5. Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou.  (2019)  Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.  International Journal of Biological Sciences,  15  (8): ( 1676–1684).  [PMID:31360110] [10.7150/ijbs.35265]
6. Yao Yao, Xia Dandan, Bian Yueping, Sun Yueyue, Zhu Feng, Pan Bin, Niu Mingshan, Zhao Kai, Wu Qingyun, Qiao Jianlin, Fu Chunling, Li Zhenyu, Xu Kailin.  (2015)  Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance.  APOPTOSIS,  20  (8): (1122-1133).  [PMID:26033479] [10.1007/s10495-015-1140-2]

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