阿卡德辛, AMP 激活蛋白激酶、AMPK 激活剂

AMP激活的蛋白激酶的细胞可渗透激活剂。1毫升水溶性包装。

规格或纯度: ≥98%

CAS编号: 2627-69-2
分子式: C₉H₁₄N₄O₅
分子量: 258.23
EC号: 220-097-5
MDL号: MFCD00869751
PubChem编号: 17513

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
A129749-50mg	50mg	现货
A129749-250mg	250mg	现货
A129749-1g	1g	现货

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

别名	阿卡地新\|5-氨基-1-beta-D-呋喃核糖基-1H-咪唑-4-甲酰胺\|5-氨基咪唑-4-甲酰胺-1-B-D-呋喃核糖苷
英文别名	ACADESINE\|2627-69-2\|AICAR\|AICA-riboside\|Arasine\|AICA riboside\|AIC-Riboside\|5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide\|Acadesina\|Acadesinum\|AICAR (Acadesine)\|GP-1-110\|Protara\|5-Amino-1-beta-D-ribofuranosylimidazole-4-carboxamide\|5-Aminoimida
规格或纯度	≥98%
英文名称	Acadesine
生化机理	AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been sμggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside).
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Acadesine导致ZMP的积累，Acadesine模仿AMP对AMPK和AMPK的刺激作用。An inhibitor of the transcription of PPARα, the coactivation of PPARα. Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. An inhibitor of the transcription of PPARα, the coactivation of PPARα.

产品属性

ALogP	-2.2

名称和标识符

PubChem SID	488182399
PubChem SID url	https://pubchem.ncbi.nlm.nih.gov/substance/488182399
EC号	220-097-5
IUPAC Name	5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
INCHI	InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChi Key	RTRQQBHATOEIAF-UUOKFMHZSA-N
Canonical SMILES	C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N
Isomeric SMILES	C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N
WGK Germany	3
PubChem CID	17513
分子量	258.23

数据库链接

CAS Registry No.	2627-69-2
Wikipedia	Acadesine
PubChem CID	17513
ChEMBL Ligand	CHEMBL1551724
DrugBank Ligand	DB04944
DrugCentral Ligand	37
PubChem SID	488182399

化学和物理性质

溶解性	Soluble in water (9 mg/ml), and DMSO (75 mM).
敏感性	对湿度敏感

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany	3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

质检证书(COA)

质检报告(COA)

输入批号以搜索COA:

产品问答

登录提交问题

查看全部

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Winder WW, Hardie DG. (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes.. Am J Physiol, 277 (1 Pt 1): (E1-10). [PMID:10409121]
2. Cuthbertson DJ, Babraj JA, Mustard KJ, Towler MC, Green KA, Wackerhage H, Leese GP, Baar K, Thomason-Hughes M, Sutherland C et al.. (2007) 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.. Diabetes, 56 (8): (2078-84). [PMID:17513706]
3. Musi N, Goodyear LJ. (2002) Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.. Curr Drug Targets Immune Endocr Metabol Disord, 2 (2): (119-27). [PMID:12476786]
4. Walker J, Jijon HB, Diaz H, Salehi P, Churchill T, Madsen KL. (2005) 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.. Biochem J, 385 (Pt 2): (485-91). [PMID:15367103]
5. Daval M, Diot-Dupuy F, Bazin R, Hainault I, Viollet B, Vaulont S, Hajduch E, Ferré P, Foufelle F. (2005) Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes.. J Biol Chem, 280 (26): (25250-7). [PMID:15878856]
6. Merrill GF, Kurth EJ, Hardie DG, Winder WW. (1997) AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.. Am J Physiol, 273 (6 Pt 1): (E1107-12). [PMID:9435525]
7. Kundu A et al.. (2020) 14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.. J Biol Chem, 295 (6): (1754-1766). [PMID:31901078]
8. Morishita M et al.. (2017) AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway.. Int J Oncol, 50 (): (23-30). [PMID:27878239]
9. Mustafa Rizvi SH et al.. (2014) Aluminium induced endoplasmic reticulum stress mediated cell death in SH-SY5Y neuroblastoma cell line is independent of p53.. PLoS One, 9 (5): (e98409). [PMID:24878590]
10. Sternlieb T et al.. (2021) An AMP-activated protein kinase complex with two distinctive alpha subunits is involved in nutritional stress responses in Trypanosoma cruzi.. PLoS Negl Trop Dis, 15 (5): (e0009435). [PMID:34029334]
11. Khan M et al.. (2015) Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy.. BMC Neurosci, 16 (): (42). [PMID:26174015]
12. Ji R et al.. (2020) Electric field down-regulates CD9 to promote keratinocytes migration through AMPK pathway.. Int J Med Sci, 17 (7): (865-873). [PMID:32308539]
13. Li F et al.. (2015) G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma.. PLoS One, 10 (9): (e0138390). [PMID:26397365]
14. Zibrova D et al.. (2017) GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.. Biochem J, 474 (6): (983-1001). [PMID:28008135]
15. Gao P et al.. (2020) Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.. Diabetes, 69 (2): (165-180). [PMID:31712319]
16. Hanada Y et al.. (2020) MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity.. Nat Commun, 11 (): (5711). [PMID:33177519]
17. Hawley SA et al.. (2020) Mechanism of Activation of AMPK by Cordycepin.. Cell Chem Biol, 27 (2): (214-222.e4). [PMID:31991096]
18. Gong Y et al.. (2020) Metformin Inhibits Tumor Metastasis through Suppressing Hsp90a Secretion in an AMPKa1-PKC? Dependent Manner.. Cells, 9 (): (). [PMID:31936169]
19. Samanta J et al.. (2020) Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway.. Cardiovasc Toxicol, 20 (3): (261-280). [PMID:31571030]
20. van Dam AD et al.. (2015) Salsalate activates brown adipose tissue in mice.. Diabetes, 64 (5): (1544-54). [PMID:25475439]
21. Tong X et al.. (2020) Suppression of AMP-activated protein kinase reverses osteoprotegerin-induced inhibition of osteoclast differentiation by reducing autophagy.. Cell Prolif, 53 (): (e12714). [PMID:31696568]

阿卡德辛, AMP 激活蛋白激酶、AMPK 激活剂

库存信息

库存信息

库存信息

基本描述

产品属性

名称和标识符

数据库链接

化学和物理性质

安全和危险性（GHS）

质检证书(COA)

质检报告(COA)

相关文档

质检报告COA

产品问答

产品问答

参考文献