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辛可尼定

奎宁类似物。溶溶剂。
规格或纯度: 98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
C109632-1g
1g 现货 Stock Image
C109632-5g
5g 现货 Stock Image
C109632-25g
25g 现货 Stock Image
C109632-100g
100g 现货 Stock Image
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六元杂环化合物 吡啶类

基本描述

别名 辛可尼丁|(9S)-6'-甲氧基辛可宁-9-醇
英文别名 CINCHONIDINE|485-71-2|(-)-Cinchonidine|(8S,9R)-Cinchonidine|Cinchovatine|alpha-Quinidine|L-Cinchonidine|Cinchovatine-|MFCD00006783|a-quinidine|TCMDC-123934|cinchonine|(8S,9R)-cinchonan-9-ol|(8alpha,9R)-Cinchonan-9-ol|1U622LRA8Z|CHEBI:3703|485-71-2 (free b
规格或纯度 98%
英文名称 Cinchonidine
生化机理 奎宁类似物。溶溶剂。抑制恶性疟原虫。干扰铁原卟啉的形成。SERT抑制剂弱。在体内显示出抗疟作用。口服具有活性
储存温度 避光
运输条件 常规运输
备注 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。
产品介绍


application:

It finds its uses as an antimalarial compound. It is a lysosomotropic agent, inhibits Plasmodium falciparum, interferes with ferriprotoporphyrin formation and is a weak SERT inhibitor.

名称和标识符

PubChem SID 488187274
EC号 207-622-3
IUPAC Name (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
INCHI InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18-,19+/m0/s1
InChi Key KMPWYEUPVWOPIM-KODHJQJWSA-N
Canonical SMILES C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
Isomeric SMILES C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](C3=CC=NC4=CC=CC=C34)O
WGK Germany 3
RTECS GD2975000
PubChem CID 101744
分子量 294.39
Beilstein号 89690
Reaxy-Rn 5286475

化学和物理性质

溶解性 不溶于水;可溶于乙醇、乙醚、氯仿
密度 1.2
敏感性 对光敏感
比旋光度 -107.5 ° (C=1, EtOH)
熔点 204-206°C

安全和危险性(GHS)

象形图
ghs08

Health Hazard

ghs07

Harmful

信号词 Warning
危险声明 H373: Causes damage to organs through prolonged or repeated exposure
H302: Harmful if swallowed
H317: May cause an allergic skin reaction
H361: Suspected of damaging fertility or the unborn child
预防措施声明 P261,P280,P302+P352,P321,P405,P501,P264,P260,P270,P272,P333+P313,P362+P364,P330,P203,P301+P317,P318,P319
WGK Germany 3
RTECS GD2975000
Reaxy-Rn 5286475
Merck Index 2286
个人防护装备 Eyeshields,Faceshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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参考文献

1. K Itoh,M Yamamura,S Muramatsu,K Hoshino,A Masubuchi,T Sasaki,Y Tanaka.  (2005-09-30)  Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase..  Xenobiotica; the fate of foreign compounds in biological systems,  35  ((6)):  (561-573).  [PMID:16192108]
2. Toshifumi Takeuchi,Takashi Mukawa,Hideyuki Shinmori.  (2005-10-08)  Signaling molecularly imprinted polymers: molecular recognition-based sensing materials..  Chemical record (New York, N.Y.),  ((5)):  (263-275).  [PMID:16211586]
3. György Szöllösi,Abhijit Chatterjee,Péter Forgó,Mihály Bartók,Fujio Mizukami.  (2006-07-15)  Structure-property relationship in py-hexahydrocinchonidine diastereomers: ab initio and NMR study..  The journal of physical chemistry. A,  109  ((5)):  (860-868).  [PMID:16838957]
4. Ryan A Olsen,Dan Borchardt,Larry Mink,Arun Agarwal,Leonard J Mueller,Francisco Zaera.  (2006-12-07)  Effect of protonation on the conformation of cinchonidine..  Journal of the American Chemical Society,  128  ((49)):  (15594-15595).  [PMID:17147361]
5. Karol M Kacprzak,Wolfgang Lindner,Norbert M Maier.  (2007-09-14)  An improved synthesis of 10,11-didehydro Cinchona alkaloids..  Chirality,  20  ((3-4)):  (441-445).  [PMID:17853397]
6. Jonas Nyhlén,Lars Eriksson,Jan-E Bäckvall.  (2007-10-30)  Synthesis and optical resolution of an allenoic acid by diastereomeric salt formation induced by chiral alkaloids..  Chirality,  20  ((1)):  (47-50).  [PMID:17966123]
7. Chun-Yin Zhu,Xian-Ming Deng,Xiu-Li Sun,Jun-Cheng Zheng,Yong Tang.  (2008-05-16)  Highly enantioselective synthesis of isoxazoline N-oxides..  Chemical communications (Cambridge, England),    ((6)):  (738-740).  [PMID:18478708]
8. Atsushi Urakawa,Daniel M Meier,Heinz Rüegger,Alfons Baiker.  (2008-07-19)  Conformational behavior of cinchonidine revisited: a combined theoretical and experimental study..  The journal of physical chemistry. A,  112  ((31)):  (7250-7255).  [PMID:18636698]
9. Jian Zhang,Shumei Chen,Tao Wu,Pingyun Feng,Xianhui Bu.  (2008-09-09)  Homochiral crystallization of microporous framework materials from achiral precursors by chiral catalysis..  Journal of the American Chemical Society,  130  ((39)):  (12882-12883).  [PMID:18774816]
10. Erik Schmidt,Wolfgang Kleist,Frank Krumeich,Tamas Mallat,Alfons Baiker.  (2009-12-30)  Platinum nanoparticles: the crucial role of crystal face and colloid stabilizer in the diastereoselective hydrogenation of cinchonidine..  Chemistry (Weinheim an der Bergstrasse, Germany),  16  ((7)):  (2181-2192).  [PMID:20039346]
11. Yueqi Liu,Kaori Hoshina,Jun Haginaka.  (2010-02-16)  Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization..  Talanta,  80  ((5)):  (1713-1718).  [PMID:20152401]
12. Sarfraz A Nawaz,Muhammad Ayaz,Wolfgang Brandt,Ludger A Wessjohann,Bernhard Westermann.  (2010-12-28)  Cation-π and π-π stacking interactions allow selective inhibition of butyrylcholinesterase by modified quinine and cinchonidine alkaloids..  Biochemical and biophysical research communications,  404  ((4)):  (935-940).  [PMID:21185266]
13. Roman Büttiker,Jürgen Ebert,Christian Hinderling,Christian Adlhart.  (2011-05-03)  Membranes for specific adsorption: immobilizing molecularly imprinted polymer microspheres using electrospun nanofibers..  Chimia,  65  ((3)):  (182-186).  [PMID:21528654]
14. Zbigniew Karczmarzyk,Teodozja M Lipińska,Waldemar Wysocki,Monika Denisiuk,Katarzyna Piechocka.  (2011-09-02)  Tosyl esters of cinchonidine and cinchonine alkaloids: the structure-reactivity relationship in the hydrolysis to 9-epibases..  Acta crystallographica. Section C, Crystal structure communications,  67  ((Pt 9)):  (o346-o349).  [PMID:21881184]
15. Nobutaka Maeda,Konrad Hungerbühler,Alfons Baiker.  (2011-11-17)  Asymmetric hydrogenation on chirally modified Pt: origin of hydrogen in the N-H-O interaction between cinchonidine and ketone..  Journal of the American Chemical Society,  133  ((49)):  (19567-19569).  [PMID:22084835]
16. Pierrick Nun,Violaine Pérez,Monique Calmès,Jean Martinez,Frédéric Lamaty.  (2012-02-11)  Preparation of chiral amino esters by asymmetric phase-transfer catalyzed alkylations of Schiff bases in a ball mill..  Chemistry (Weinheim an der Bergstrasse, Germany),  18  ((12)):  (3773-3779).  [PMID:22322525]
17. Arkajyoti Sengupta,Raghavan B Sunoj.  (2012-11-17)  Mechanistic insights on organocatalytic enantioselective decarboxylative protonation by epicinchona-thiourea hybrid derivatives..  The Journal of organic chemistry,  77  ((23)):  (10525-10536).  [PMID:23153357]
18. Fumihiko Kitagawa,Hiroshi Sudaki,Kenji Sueyoshi,Koji Otsuka.  (2013-01-11)  Open-tubular electrochromatographic chiral separation of amino acids using an organic nanocrystals immobilized capillary..  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry,  29  ((1)):  (107-112).  [PMID:23303094]
19. Matthew L Beckman,Akula Bala Pramod,Danielle Perley,L Keith Henry.  (2013-10-29)  Stereoselective inhibition of serotonin transporters by antimalarial compounds..  Neurochemistry international,  73  ():  (98-106).  [PMID:24161619]
20. Oleg V Larionov,David Stephens,Adelphe Mfuh,Gabriel Chavez.  (2014-01-15)  Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides..  Organic letters,  16  ((3)):  (864-867).  [PMID:24410049]
21. Angelo Vargas,Norberto Bonalumi,Davide Ferri,Alfons Baiker.  (2006-01-20)  Solvent-induced conformational changes of O-phenyl-cinchonidine: a theoretical and VCD spectroscopy study..  The journal of physical chemistry. A,  110  ((3)):  (1118-1127).  [PMID:16420016]
22. Simon Diezi,Davide Ferri,Angelo Vargas,Tamas Mallat,Alfons Baiker.  (2006-03-23)  The origin of chemo- and enantioselectivity in the hydrogenation of diketones on platinum..  Journal of the American Chemical Society,  128  ((12)):  (4048-4057).  [PMID:16551114]
23. Erik Schmidt,Davide Ferri,Alfons Baiker.  (2007-06-23)  Surface processes occurring on Rh/alumina during chiral modification by cinchonidine: an ATR-IR spectroscopy study..  Langmuir : the ACS journal of surfaces and colloids,  23  ((15)):  (8087-8093).  [PMID:17583922]
24. Kensuke Fukiya,Kunio Itoh,Satoshi Yamaguchi,Akiko Kishiba,Mayuko Adachi,Nobuaki Watanabe,Yorihisa Tanaka.  (2009-11-17)  A single amino acid substitution confers high cinchonidine oxidation activity comparable with that of rabbit to monkey aldehyde oxidase 1..  Drug metabolism and disposition: the biological fate of chemicals,  38  ((2)):  (302-307).  [PMID:19910515]
25. Ping Liu,Sun Liang,Ben-Jie Wang,Rui-Chen Guo.  (2010-02-20)  Construction of expression system of rabbit aldehyde oxidase cDNA for the clarification of species differences..  European journal of drug metabolism and pharmacokinetics,  34  ((3-4)):  (205-211).  [PMID:20166440]
26. Sonia Keunchkarian,Jaiver Osorio Grisales,Juan M Padró,Susana Boeris,Cecilia B Castells.  (2012-05-11)  Development of a chiral stationary phase based on cinchonidine. Comparison with a quinine-based chiral column..  Chirality,  24  ((7)):  (512-518).  [PMID:22573362]
27. Naoki Haraguchi,Parbhej Ahamed,Md Masud Parvez,Shinichi Itsuno.  (2012-06-21)  Synthesis of main-chain chiral quaternary ammonium polymers for asymmetric catalysis using quaternization polymerization..  Molecules (Basel, Switzerland),  17  ((6)):  (7569-7583).  [PMID:22713348]
28. Nicholas G Spiropulos,Jennifer M Heemstra.  (2013-02-02)  Templating effect in DNA proximity ligation enables use of non-bioorthogonal chemistry in biological fluids..  Artificial DNA, PNA & XNA,  ((3)):  (123-128).  [PMID:23370267]
29. Neng-jun Zhong,Li Liu,Dong Wang,Yong-Jun Chen.  (2013-03-28)  Enantioselective tandem reaction of chromone-derived Morita-Baylis-Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones..  Chemical communications (Cambridge, England),  49  ((35)):  (3697-3699).  [PMID:23532090]