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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C125911-10mg |
10mg |
现货  |
| |
| C125911-50mg |
50mg |
现货 |
|
| 别名 | 西地尼布 |
|---|---|
| 英文别名 | AZD2171|NSC755606|NSC-755606|MFCD09954115|Recentin|Cediranib - AZD2171|D08881|N-acetyl-N-formyl-5-methoxykynuramine|XXJWYDDUDKYVKI-UHFFFAOYSA-N|A24280|AZD 2171|HY-10205|ZD-2171|SCHEMBL157630|4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-pyrrolidin |
| 规格或纯度 | ≥98% |
| 英文名称 | Cediranib |
| 生化机理 | Cediranib is VEGFR2 inhibitor. Cediranib inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50s of 0.4 and 0.5 nM, respectively. |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Cediranib (AZD2171)是一种高效的VEGFR(KDR)抑制剂，IC50为<1 nM，同时也抑制Flt1/4，IC50为5 nM/≤3 nM，此外对c-Kit和PDGFRβ也具有相似的抑制活性，对VEGFR的选择性比PDGFR-α， CSF-1R和Flt3分别高36倍， 110倍 和1000倍以上。Phase 3。 Cediranib (AZD2171) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3, Phase 3. |
| ALogP | 4.9 |
|---|
| IUPAC Name | 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline |
|---|---|
| INCHI | InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 |
| InChi Key | XXJWYDDUDKYVKI-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 |
| Isomeric SMILES | CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 |
| PubChem CID | 9933475 |
| 分子量 | 450.52 |
| CAS Registry No. | 288383-20-0 |
|---|---|
| Wikipedia | Cediranib |
| DiscoveRx TREEspot | AZD-2171| |
| PubChem CID | 9933475 |
| ChEMBL Ligand | CHEMBL491473 |
| Reactome Reaction | R-HSA-2023462, R-HSA-2029992 |
| Reactome Drug | R-ALL-2023377 |
| 溶解性 | DMSO 90 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
|---|
| 象形图 |
Toxic 
Health Hazard 
Environmental Hazard 
Harmful |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H315: Causes skin irritation H301: Toxic if swallowed H312: Harmful in contact with skin H410: Very toxic to aquatic life with long lasting effects H372: Causes damage to organs through prolonged or repeated exposure H361: Suspected of damaging fertility or the unborn child |
| 预防措施声明 | P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P391,P330,P203,P301+P316,P318,P317,P332+P317,P319 |
输入批号以搜索COA:
| 1. Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, Smith NR, James NH, Dukes M, Curwen JO et al.. (2005) AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.. Cancer Res, 65 (10): (4389-400). [PMID:15899831] |
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