柔红霉素盐酸盐, DNA 抑制剂

货号 (SKU)	包装规格	是否现货
D122335-10mg	10mg	现货
D122335-50mg	50mg	现货
D122335-250mg	250mg	现货
D122335-1g	1g	期货

基本描述

别名	盐酸柔红霉素\|柔红霉素盐酸盐\|道诺霉素盐酸盐
英文别名	23541-50-6\|DAUNORUBICIN HCL\|DAUNORUBICIN HYDROCHLORIDE\|Daunomycin hydrochloride\|Daunoblastina\|Rubidomycin hydrochloride\|Cerubidine\|Ondena\|RP 13057 hydrochloride\|Daunomycin chlorohydrate\|Daunomycin HCL\|Daunomycin, hydrochloride\|RP-13057 Hydrochloride\|NDC 0
规格或纯度	>90%
英文名称	Daunorubicin hydrochloride
生化机理	强效抗癌剂，已证明是 DNA 和 RNA 合成的强抑制剂。性质自发荧光的蒽环类抗生素，抗癌药。Pgp、MRP-1 和 BCRP 的底物。已利用荧光特性来测量药物外排泵活性，以及解决许多重要问题，如多种多药耐药蛋白的胞内定位和亚细胞器（高尔基体和溶酶体）在药物螯合中的作用及其在耐药表型中的含义。根据 pH 分配型机理将柔红霉素螯合进溶酶体。蒽环类抗生素。DNA和RNA合成抑制剂。降低tau mRNA水平。诱导DNA片段化和凋亡。在体内具有抗增殖和细胞毒性作用。口服具有活性
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Daunorubicin HCl抑制DNA和RNA合成，抑制DNA合成时，Ki为0.02 μM。强效抗癌剂，已证明是 DNA 和 RNA 合成的强抑制剂。自发荧光的蒽环类抗生素，抗癌药。Pgp、MRP-1 和 BCRP 的底物。已利用荧光特性来测量药物外排泵活性，以及解?决许多重要问题，如多种多药耐药蛋白的胞内定位和亚细?胞器（高尔基体和溶酶体）在药物螯合中的作用及其在耐?药表型中的含义。根据 pH 分配型机理将柔红霉素螯合进溶酶体。DNA 和 RNA 合成的强抑制剂。A DNA intercalator which may suppress acute leukemia proliferation Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. A DNA intercalator which may suppress acute leukemia proliferation

名称和标识符

PubChem SID	488183611
PubChem SID url	https://pubchem.ncbi.nlm.nih.gov/substance/488183611
EC号	245-723-4
IUPAC Name	(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
INCHI	InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChi Key	GUGHGUXZJWAIAS-QQYBVWGSSA-N
Canonical SMILES	CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl
Isomeric SMILES	C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl
WGK Germany	3
RTECS	HB7878000
关联CAS	20830-81-3
PubChem CID	62770
UN Number	2811
Packing Group	I
分子量	563.98
Beilstein号	4229221

数据库链接

PubChem SID	488183611

化学和物理性质

溶解性	Soluble in water (≥113), methanol, ethanol (≥10), and DMSO (≥72 mg/mL).
敏感性	对湿度、热，光线敏感
比旋光度	260°
熔点	167 °C

安全和危险性（GHS）

象形图	Toxic Health Hazard Harmful
信号词	Danger
危险声明	H301: Toxic if swallowed H341: Suspected of causing genetic defects H351: Suspected of causing cancer H302: Harmful if swallowed H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled H360: May damage fertility or the unborn child
预防措施声明	P261,P280,P321,P405,P501,P264,P284,P281,P270,P304+P340,P330,P203,P301+P316,P301+P317,P318,P342+P316
WGK Germany	3
RTECS	HB7878000
Class	6.1
Merck Index	2832
个人防护装备	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

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