基本描述

英文别名	2-(3,4-dimethoxyphenyl)-5-(5-(4 methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-benzimidazole \| DMA (hydrochloride) \| 2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)- \| 2'-(3,4-Dimethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'
规格或纯度	≥97%
英文名称	DMA
生化机理	描述：IC50 值：不适用Hoechst 染色剂属于用于染色 DNA 的蓝色荧光染料系列。这些双苯亚胺最初由 Hoechst AG 公司开发，该公司对其所有化合物进行了编号，因此染料 Hoechst 33342 是该公司生产的第 33342 种化合物。有三种相关的 Hoechst 染色剂：Hoechst 33258、Hoechst 33342 和 Hoechst 34580。Hoechst 33258 和 Hoechst 33342 是最常用的染料，它们具有相似的激发/发射光谱。这两种染料都能被 350 纳米左右的紫外线激发，并在 461 纳米的发射最大值附近发出蓝色/青色荧光。未结合染料的最大荧光发射波长在 510-540 纳米范围内。Hoechst 染料可溶于水和二甲基甲酰胺或二甲亚砜等有机溶剂。浓度最高可达 10 mg/mL。水溶液在 2-6 °C 避光条件下可稳定保存至少 6 个月。染料与双链 DNA 的小沟结合，偏好富含腺嘌呤和胸腺嘧啶的序列。尽管染料可与所有核酸结合，但富含 AT 的双链 DNA 链可显著增强荧光。Hoechst 染料具有细胞渗透性，可与活细胞或固定细胞中的 DNA 结合。Hoechst 染料具有细胞渗透性，可与活细胞或固定细胞中的 DNA 结合。因此，这些染色剂通常被称为 "超活力"（supravital）染色剂，这意味着细胞在这些化合物的处理下可以存活。表达特定 ATP 结合盒转运蛋白的细胞也能主动将这些染色剂转运出细胞质：体内：无/临床试验：不适用
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	DMA 是一种荧光化合物 (λex=340 nm, λem=478 nm)。 DMA is a fluorescent compound (λex=340 nm, λem=478 nm).

AI解读

关联靶点（人）

MCF7 (126967 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 活性数据)

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关联靶点（其它种属）

Calf thymus DNA (4845 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504765296
分子类型	小分子
IUPAC Name	2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole
INCHI	InChI=1S/C27H28N6O2/c1-32-10-12-33(13-11-32)19-6-8-21-23(16-19)31-26(29-21)17-4-7-20-22(14-17)30-27(28-20)18-5-9-24(34-2)25(15-18)35-3/h4-9,14-16H,10-13H2,1-3H3,(H,28,30)(H,29,31)
InChi Key	BMRRDFCQNOZNNR-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=C(C=C6)OC)OC
Isomeric SMILES	CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=C(C=C6)OC)OC
PubChem CID	10174012
分子量	468.55

化学和物理性质

溶解性	25°C: DMSO or water Protect from light
分子量	468.500 g/mol
XLogP3	4.300
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	5
精确质量Exact Mass	468.227 Da
单同位素质量Monoisotopic Mass	468.227 Da
拓扑极表面积Topological Polar Surface Area	82.300 Å²
重原子数Heavy Atom Count	35
形式电荷Formal Charge	0
复杂度Complexity	705.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

技术规格说明书

Purity(HPLC)	97-100（%）
NMR spectrum	Conforms to Structure

技术规格说明书

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批号(Lot Number)	证书类型	日期	货号
F2405151	分析证书	23-08-18	D125044
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K2113241	分析证书	23-08-18	D125044
K2113242	分析证书	23-08-18	D125044

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溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
D125044-5mg	5mg	现货
D125044-25mg	25mg	现货
D125044-50mg	50mg	现货
D125044-100mg	100mg	现货
D125044-250mg	250mg	现货

2'-(3,4-二甲氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-双[1H-苯并咪唑](DMA)

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器