Dorsomorphin

货号 (SKU)	包装规格	是否现货
D139352-5mg	5mg	现货
D139352-25mg	25mg	现货
D139352-100mg	100mg	现货

基本描述

别名	6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-a]嘧啶\|AMPK 抑制剂
英文别名	dorsomorphin\|866405-64-3\|6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine\|BML-275\|Compound C\|AMPK Inhibitor, Compound C\|6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine\|Dorsomorphin free base\|866
规格或纯度	≥98%
英文名称	Dorsomorphin
生化机理	Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomorphin also acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP).Potent, selective and reversible inhibitor of AMP-kinase (K i = 109 nM). Inhibits AMPK activation induced by AICAR and metformin . Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).
储存温度	2-8°C储存,避光,充氩
运输条件	冰袋运输
备注	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Please note that sonication\xa0in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
产品介绍	Dorsomorphin (Compound C) 是一种选择性，ATP 竞争性的 AMPK 抑制剂 (在没有 AMP 的情况下，Ki 为 109 nM)。Dorsomorphin 选择性抑制 BMP I 型受体 ALK2，ALK3 和 ALK6。Dorsomorphin 还能够逆转 Urolithin A (HY-100599) 导致的自噬 (autophagy) 激活和抗炎作用。 Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin. Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599)。

名称和标识符

IUPAC Name	6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
INCHI	InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChi Key	XHBVYDAKJHETMP-UHFFFAOYSA-N
Canonical SMILES	C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
Isomeric SMILES	C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
WGK Germany	3
PubChem CID	11524144
分子量	399.49

数据库链接

CAS Registry No.	866405-64-3
PubChem CID	11524144
ChEMBL Ligand	CHEMBL478629
RCSB PDB Ligand	TAK

化学和物理性质

溶解性	Soluble in DMSO (4 mg/ml warm), 100 mM HCl, and MeOH.
敏感性	对空气、光线和热敏感

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H302: Harmful if swallowed H312: Harmful in contact with skin H332: Harmful if inhaled
预防措施声明	P261,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P301+P317,P317
WGK Germany	3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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参考文献

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Dorsomorphin

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库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全和危险性（GHS）

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