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生物活性小分子
Docosahexaenoyl Ethanolamide

Docosahexaenoyl Ethanolamide

DHA的乙醇胺酰胺

≥98%
25mg/ml in ethanol

CAS编号: 162758-94-3
分子式: C₂₄H₃₇NO₂
分子量: 371.56
PubChem编号: 5283451

有货

库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
D335344-5mg	5mg	现货
D335344-10mg	10mg	现货

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基本描述

别名	(4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-羟基乙基)-4,7,10,13,16,19-二十二碳六烯酰胺 \| 二十二碳六烯酰乙醇酰胺
英文别名	HMS3650G19 \| Q27158436 \| N-(2-hydroxyethyl)-4(Z),7(Z),10(Z),13(Z),16(Z),19(Z)-docosahexaenamide \| SCHEMBL1228084 \| Synaptamide \| Anandamide (22:6, n-3) \| BDBM50463963 \| N-(2-Hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide \| EX-A7999E \| (4Z,7Z,10Z,13Z,16Z,
规格或纯度	≥98%, 25mg/ml in ethanol
英文名称	Docosahexaenoyl Ethanolamide
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Synaptamide (Dehydroepiandrosteron; DHEA) 是一种内源性代谢物，是 Anandamide 的结构类似物。Synaptamide 与大麻素-1 和 2 (CB1 和 CB2) 大麻素受体结合并具有抗炎特性。Synaptamide 第一个粘附 G 蛋白偶联受体 (aGPCR) 的小分子内源性配体。产品以溶液形式提供。 Docosahexaenoyl Ethanolamide (DHEA) is an ethanolamine amide of DHA that has been detected in both retina and brain at concentrations similar to those for arachidonoyl ethanolamide (AEA). Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, particularly in the retina and brain. A 9.5 fold increase of DHEA was observed in brain lipid extracts from piglets on a DHA-supplemented diet compared to a DHA-free control diet. DHEA binds rat brain CB1 receptor with a K\|i\|of 324 nM, which is about 10-fold higher than the K\|i\|for AEA. DHEA inhibits shaker-related voltage-gated potassium channels in the brain slightly better than AEA, with an IC\|50\|of 1.5 μM.

AI解读

产品属性

pKa值	pKa: 15.45 (Predicted), pKa: -0.48 (Predicted)
Ki Data	CB1: Ki= 324 nM (rat brain)
IC50	Shaker-related voltage-gated potassium channels: IC₅₀= 1.5 μM (brain)

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关联靶点（其它种属）

Faah Anandamide amidohydrolase (3907 活性数据)

点击查看靶蛋白信息： Faah

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Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 活性数据)

点击查看靶蛋白信息： Trpv2

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作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IUPAC Name	(4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide
INCHI	InChI=1S/C24H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24(27)25-22-23-26/h3-4,6-7,9-10,12-13,15-16,18-19,26H,2,5,8,11,14,17,20-23H2,1H3,(H,25,27)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChi Key	GEEHOLRSGZPBSM-KUBAVDMBSA-N
Canonical SMILES	CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)NCCO
Isomeric SMILES	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCO
WGK Germany	3
PubChem CID	5283451
分子量	371.56

化学和物理性质

溶解性	Soluble in ethanol, DMSO (~20 mg/ml), DMF (~20 mg/ml), PBS (pH 7.2) (~0.15 mg/ml), and water (0.15 mg/ml at 25° C).
折光率	n20D1.52 (Predicted)
沸点	78° C
分子量	371.600 g/mol
XLogP3	5.300
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	16
精确质量Exact Mass	371.282 Da
单同位素质量Monoisotopic Mass	371.282 Da
拓扑极表面积Topological Polar Surface Area	49.300 Å²
重原子数Heavy Atom Count	27
形式电荷Formal Charge	0
复杂度Complexity	510.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	6
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	6
共价键合单元计数Covalently-Bonded Unit Count	1