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鞣花酸水合物

酪蛋白激酶抑制剂

规格或纯度: 98%

CAS编号: 314041-08-2
分子式: C₁₄H₆O₈.H₂O
分子量: 320.21
PubChem编号: 16212384

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货号 (SKU)	包装规格	是否现货	价格	数量
E413293-25mg	25mg	现货
E413293-100mg	100mg	现货
E413293-500mg	500mg	现货
E413293-1g	1g	现货

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基本描述

规格或纯度	98%
英文名称	Ellagic Acid hydrate
生化机理	Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Information Ellagic Acid hydrate Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties. Targets CK2 (Cell-free assay); Lyn (Cell-free assay); PKA (Cell-free assay) 0.04 μM; 2.9 μM; 3.5 μM In vitro Ellagic acid (EA) is able to inhibit the growth of several cancer cells. EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced caspase-3-mediated apoptosis by increasing the Bax\u2009:\u2009Bcl-2 ratio and restored anoikis in ES-2 and PA-1 cells. It is well known to have a free radical scavenging activity. EA reversed epithelial to mesenchymal transition by up-regulating E-cadherin and down-regulating Vimentin. In vivo A 90-day subchronic toxicity study further demonstrated that orally feeding EA (9.4, 19.1, 39.1\u2009g/kg b.w., resp.) could not induce mortality or treatment-related clinical signs throughout the experimental period on F344 rats, indicating the low toxicity of EA to mammalians. Furthermore, EA exhibits potent anticancer and anticarcinogenesis activities towards breast, colorectal, oral, prostate, pancreatic, bladder, neuroblastoma, melanoma, and lymphoma cells. Treatment of PANC-1 xenografted mice with EA resulted in significant inhibition in tumor growth and prolong mice survival rate. Cell Research(from reference) Cell lines：Ovarian carcinoma ES-2 and PA-1 cells Concentrations：10~100\u2009μM Incubation Time：12, 24, 48 h

名称和标识符

PubChem SID	488199157
IUPAC Name	6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione;hydrate
INCHI	InChI=1S/C14H6O8.H2O/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19;/h1-2,15-18H;1H2
InChi Key	UOZZJRXBNGVIKO-UHFFFAOYSA-N
Canonical SMILES	C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O.O
Isomeric SMILES	C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O.O
PubChem CID	16212384
分子量	320.21

数据库链接

PubChem SID	488199157

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 2 mg/mL (6.24 mM);

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