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氟伏沙明

选择性5-羟色胺再摄取抑制剂

规格或纯度: 98%

CAS编号: 54739-18-3
分子式: C₁₅H₂₁F₃N₂O₂
分子量: 318.33
PubChem编号: 5324346

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货号 (SKU)	包装规格	是否现货	价格	数量
F337893-25mg	25mg	现货
F337893-100mg	100mg	期货

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SERT Inhibitor sigma non-opioid intracellular receptor 1

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基本描述

英文别名	fluvoxamine\|54739-18-3\|Fluvoxamina\|Fluvoxaminum\|Fluvoxaminum [INN-Latin]\|Fluvoxamina [INN-Spanish]\|UNII-O4L1XPO44W\|O4L1XPO44W\|Fluvoxamine (INN)\|2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine\|CHEBI:5138\|DTXSID2044002\|N06AB08
规格或纯度	98%
英文名称	Fluvoxamine
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	氟伏沙明是选择性5-羟色胺再摄取抑制剂（SSRI）和Sigma 受体的激活剂。 Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) and an activator of Sigma Receptor.

名称和标识符

IUPAC Name	2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
INCHI	InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+
InChi Key	CJOFXWAVKWHTFT-XSFVSMFZSA-N
Canonical SMILES	COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F
Isomeric SMILES	COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)C(F)(F)F
PubChem CID	5324346
分子量	318.33

数据库链接

DrugBank Ligand	DB00176
PubChem CID	5324346
CAS Registry No.	54739-18-3
ChEMBL Ligand	CHEMBL814
Wikipedia	Fluvoxamine
ChEBI	CHEBI:5138
RCSB PDB Ligand	FVX
PEP	fluvoxamine
Reactome Reaction	R-HSA-9679780
Reactome Drug	R-ALL-9679783
DrugCentral Ligand	1230

化学和物理性质

溶解性	Soluble in Chloroform, Dichloromethane, and Petroleum Ether

安全和危险性（GHS）

象形图	Toxic Environmental Hazard Corrosive Harmful
信号词	Danger
危险声明	H319: Causes serious eye irritation H335: May cause respiratory irritation H331: Toxic if inhaled H302: Harmful if swallowed H318: Causes serious eye damage H332: Harmful if inhaled H410: Very toxic to aquatic life with long lasting effects
预防措施声明	P261,P305+P351+P338,P273,P280,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P391,P330,P264+P265,P301+P317,P305+P354+P338,P317,P337+P317,P316,P319

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参考文献

1. Cobos EJ, Entrena JM, Nieto FR, Cendán CM, Del Pozo E. (2008) Pharmacology and therapeutic potential of sigma(1) receptor ligands.. Curr Neuropharmacol, 6 (4): (344-66). [PMID:19587856]
2. Yu LF, Zhang HK, Gunosewoyo H, Kozikowski AP. (2012) From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design.. ACS Med Chem Lett, 3 (12): (1054-1058). [PMID:23641311]
3. Hashimoto K. (2015) Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication.. J Pharmacol Sci, 127 (1): (6-9). [PMID:25704012]
4. Sukhatme VP, Reiersen AM, Vayttaden SJ, Sukhatme VV. (2021) Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19.. Front Pharmacol, 12 (13): (652688). [PMID:33959018]
5. Wu H, Denna TH, Storkersen JN, Gerriets VA. (2019) Beyond a neurotransmitter: The role of serotonin in inflammation and immunity.. Pharmacol Res, 140 (13): (100-114). [PMID:29953943]
6. Costa LHA, Santos BM, Branco LGS. (2020) Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?. Eur J Pharmacol, 889 (13): (173629). [PMID:33022271]
7. Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, Miller JP, Yang L, Yingling M, Avidan MS et al.. (2020) Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial.. JAMA, 324 (22): (2292-2300). [PMID:33180097]
8. Schoenichen C, Bode C, Duerschmied D. (2019) Role of platelet serotonin in innate immune cell recruitment.. Front Biosci (Landmark Ed), 24 (13): (514-526). [PMID:30468670]
9. Rosen DA, Seki SM, Fernández-Castañeda A, Beiter RM, Eccles JD, Woodfolk JA, Gaultier A. (2019) Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.. Sci Transl Med, 11 (478): (1755-70). [PMID:30728287]

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