JavaScript 似乎在您的浏览器中禁用。 在我们的网站上获得最佳体验，请务必打开 Javascript 在您的浏览器。

为了获得访问"阿拉丁铁蛋"实时聊天框的流畅支持体验，建议您使用Chrome浏览器或选择360浏览器极速模式(如何切换极速模式?)，感谢您选择我们！

切换导航

我的购物车

搜索

格拉司琼

规格或纯度: ≥98.0%

CAS编号: 109889-09-0
分子式: C₁₈H₂₄N₄O
分子量: 312.41
PubChem编号: 5284566

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
G127257-5mg	5mg	现货
G127257-25mg	25mg	现货
G127257-100mg	100mg	现货
G127257-250mg	250mg	现货

查看相关系列

5-HT3A Antagonist

Skip to the end of the images gallery

main product photo

Skip to the beginning of the images gallery

基本描述

英文别名	granisetron\|109889-09-0\|Sancuso\|Sustol\|Kevatril\|Granisetronum\|APF530\|Kytril\|BRL-43694\|1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide\|CHEBI:5537\|BRL 43694\|APF 530\|WZG3J2MCOL\|1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.
规格或纯度	≥98.0%
英文名称	Granisetron
生化机理	Description: IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) [1] Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. in vitro: In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT [1]. in vivo: Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion [2]. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation [3]. Clinical trial: Effect of External Heat on a Transdermal Granisetron Patch in Pharmacokinetics (PK) of Healthy Subjects. Phase 1
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

名称和标识符

IUPAC Name	1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide
INCHI	InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,13-,14+
InChi Key	MFWNKCLOYSRHCJ-AGUYFDCRSA-N
Canonical SMILES	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
Isomeric SMILES	CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
PubChem CID	5284566
分子量	312.41

数据库链接

DrugBank Ligand	DB00889
Wikipedia	Granisetron
CAS Registry No.	109889-09-0
PubChem CID	5284566

化学和物理性质

溶解性	DMSO:11 mg/mL

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H319: Causes serious eye irritation H412: Harmful to aquatic life with long lasting effects H302: Harmful if swallowed
预防措施声明	P305+P351+P338,P273,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

质检证书(COA)

质检报告(COA)

输入批号以搜索COA:

相关文档

质检报告COA

请输入批号:

SDS中文版 SDS英文版

质量技术规格说明书

产品问答

产品问答

登录提交问题

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

上海阿拉丁生化科技股份有限公司

销售条款及条件隐私政策

© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

沪公网安备 31012002004058号沪ICP备09093490号-2

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

危险品化学品经营许可证（带存储）

营业执照(三证合一)