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3'-羟基紫檀烯

ERK活化剂

规格或纯度: 99%

CAS编号: 475231-21-1
分子式: C₁₆H₁₆O₄
分子量: 272.3
PubChem编号: 10038868

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货号 (SKU)	包装规格	是否现货	价格	数量
H413079-5mg	5mg	现货
H413079-25mg	25mg	现货
H413079-100mg	100mg	现货

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基本描述

别名	3'-羟基紫檀茋
英文别名	475231-21-1\|3'-Hydroxypterostilbene\|(E)-4-(3,5-Dimethoxystyryl)benzene-1,2-diol\|CHEMBL332610\|4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol\|4-((e)-2-(3,5-dimethoxyphenyl)ethenyl)benzene-1,2-diol\|3?-Hydroxypterostilbene\|3'-HPT\|SCHEMBL13222741\|SCHEM
规格或纯度	99%
英文名称	3'-Hydroxypterostilbene
生化机理	3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
储存温度	避光,-20°C储存
运输条件	超低温冰袋运输
产品介绍	Information 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways. Targets p70S6K ; p38MAPK In vitro 3\'-Hydroxypterostilbene decreases cell growth in cultured human colon cancer cells (COLO 205, HCT-116, and HT-29) in a dose-dependent manner, with IC50 values of 9.0, 40.2, and 70.9 µM, respectively. 3\'-Hydroxypterostilbene effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. Treatment with HPSB causes reduction of mitochondrial membrane potential and induction of caspase-3 and caspage-9, which is associated with the degradation of DFF-45 and PARP, precedes the onset of apoptosis. It significantly down-regulates phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinases (MAPKs) signalings including decreased the phosphorylation of mammalian target of rapamycin (mTOR). In vivo 3\'-Hydroxypterostilbene by i.p. injection has anti-tumor efficacy gainst colon cancer through the inhibition of inflammation, metastasis, and angiogenesis as well as through the induction of apoptosis. Cell Research(from reference) Cell lines：COLO 205 cells Concentrations：5-100 µM Incubation Time：24 h

名称和标识符

IUPAC Name	4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol
INCHI	InChI=1S/C16H16O4/c1-19-13-7-12(8-14(10-13)20-2)4-3-11-5-6-15(17)16(18)9-11/h3-10,17-18H,1-2H3/b4-3+
InChi Key	UQRBFXIUUDJHSN-ONEGZZNKSA-N
Canonical SMILES	COC1=CC(=CC(=C1)C=CC2=CC(=C(C=C2)O)O)OC
Isomeric SMILES	COC1=CC(=CC(=C1)/C=C/C2=CC(=C(C=C2)O)O)OC
PubChem CID	10038868
分子量	272.3

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 54 mg/mL (198.31 mM); Ethanol: 54 mg/mL (198.31 mM); Water: Insoluble;
敏感性	对光线敏感

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