CAS(587871-26-9),KU-55933(ATM激酶抑制剂),587871-26-9|KU-55933|2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one|KU55933|ATM Kinase Inhibitor|KU 55933|2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one|2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one|,KU-55933 (ATM Kina

货号 (SKU)	包装规格	是否现货
K126884-5mg	5mg	现货
K126884-25mg	25mg	现货
K126884-100mg	100mg	现货

基本描述

英文别名	587871-26-9\|KU-55933\|2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one\|KU55933\|ATM Kinase Inhibitor\|KU 55933\|2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one\|2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one\|KU-55933 (ATM Kinase Inhibitor)\|CHEMBL222102\|O549494L5D
规格或纯度	≥98%
英文名称	KU-55933 (ATM Kinase Inhibitor)
生化机理	KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drμgs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.Potent, selective and competitive ATM kinase inhibitor. IC 50 values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), >100000 (ATR) and >100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics.
应用	A cell-permeable, potent, selective and ATP-competitive ATM inhibitor
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	KU-55933是ATM抑制剂，IC50和Ki分别为13和2.2 nM，对DNA-PK，PI3K/PI4K，ATR和mTOR的活性较低。A cell-permeable, potent, selective and ATP-competitive ATM inhibitor KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. A cell-permeable, potent, selective and ATP-competitive ATM inhibitor

名称和标识符

IUPAC Name	2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one
INCHI	InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChi Key	XRKYMMUGXMWDAO-UHFFFAOYSA-N
Canonical SMILES	C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
Isomeric SMILES	C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
WGK Germany	3
PubChem CID	5278396
分子量	395.49

数据库链接

PubChem CID	5278396
ChEMBL Ligand	CHEMBL222102
CAS Registry No.	587871-26-9
RCSB PDB Ligand	UF8

化学和物理性质

溶解性	DMSO 33 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
密度	1.42
折光率	1.71
沸点	628.01° C at 760 mmHg
熔点	229.98°C

安全和危险性（GHS）

WGK Germany	3

质检证书(COA)

质检报告(COA)

输入批号以搜索COA:

产品问答

登录提交问题

查看全部

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.. Cancer Res, 64 (24): (9152-9). [PMID:15604286]
2. Kubota S et al.. (2014) Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage.. J Biol Chem, 289 (9): (5730-46). [PMID:24421316]
3. Bunch H et al.. (2021) BRCA1-BARD1 regulates transcription through modulating topoisomerase IIß.. Open Biol, 11 (10): (210221). [PMID:34610268]
4. Lee K et al.. (2015) Cyclo(phenylalanine-proline) induces DNA damage in mammalian cells via reactive oxygen species.. J Cell Mol Med, 19 (12): (2851-64). [PMID:26416514]
5. Zeman MK et al.. (2014) DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.. J Cell Biol, 206 (2): (183-97). [PMID:25023518]
6. Lv J et al.. (2017) Feedback regulation of methyl methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatin.. Tumour Biol, 39 (3): (1010428317694307). [PMID:28347251]
7. Berger G et al.. (2015) G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex.. J Virol, 89 (): (230-40). [PMID:25320300]
8. Brustel J et al.. (2018) Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin.. Sci Rep, 8 (): (3850). [PMID:29497062]
9. Poletto M et al.. (2017) Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells.. Nucleic Acids Res, 45 (17): (10042-10055). [PMID:28973444]
10. Wakasugi M et al.. (2014) Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells.. J Biol Chem, 289 (41): (28730-7). [PMID:25164823]
11. Yamamoto Y et al.. (2018) Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.. Brain Res, 1687 (): (82-94). [PMID:29510140]
12. Uehara M et al.. (2020) Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.. Sci Rep, 10 (): (4441). [PMID:32157166]
13. Hilton BA et al.. (2017) Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.. FASEB J, 31 (9): (3882-3893). [PMID:28515154]
14. Isobe SY et al.. (2021) Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.. Cell Rep, 36 (2): (109383). [PMID:34260925]
15. Chung G et al.. (2015) REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans.. Genes Dev, 29 (18): (1969-79). [PMID:26385965]
16. Sun C et al.. (2020) Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.. EMBO J, 39 (21): (e103420). [PMID:32935380]
17. Pancholi NJ & Weitzman MD. (2018) Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex.. Virology, 518 (): (221-231). [PMID:29547809]
18. Sherrard A et al.. (2018) Streamlined histone-based fluorescence lifetime imaging microscopy (FLIM) for studying chromatin organisation.. Biol Open, 7 (3): (). [PMID:29535103]
19. Huang J et al.. (2020) Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.. Mol Cell, 79 (5): (824-835.e5). [PMID:32649882]
20. Garvin AJ et al.. (2019) The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.. Genes Dev, 33 (5-6): (333-347). [PMID:30796017]
21. Okumoto K et al.. (2020) The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation.. Elife, 9 (): (). [PMID:32831175]
22. Meng Y et al.. (2019) TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity.. Nucleic Acids Res, 47 (14): (7564-7579). [PMID:31216032]
23. Bunch H et al.. (2015) Transcriptional elongation requires DNA break-induced signalling.. Nat Commun, 6 (): (10191). [PMID:26671524]
24. Kim W et al.. (2019) ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.. Nat Commun, 10 (): (5304). [PMID:31757956]

KU-55933(ATM激酶抑制剂)

库存信息

库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全和危险性（GHS）

质检证书(COA)

质检报告(COA)

相关文档

质检报告COA

产品问答

产品问答

参考文献